U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    POLR1G RNA polymerase I subunit G [ Homo sapiens (human) ]

    Gene ID: 10849, updated on 27-Nov-2024

    Summary

    Official Symbol
    POLR1Gprovided by HGNC
    Official Full Name
    RNA polymerase I subunit Gprovided by HGNC
    Primary source
    HGNC:HGNC:24219
    See related
    Ensembl:ENSG00000117877 MIM:107325; AllianceGenome:HGNC:24219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASE1; CAST; ASE-1; PAF49; RPA34; CD3EAP
    Summary
    Enables RNA binding activity. Involved in transcription initiation at RNA polymerase I promoter. Located in cytosol; mitochondrion; and nuclear lumen. Part of RNA polymerase I complex. Implicated in multiple myeloma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in skin (RPKM 8.1), ovary (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POLR1G in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45406644..45410737)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48233891..48237984)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45909902..45913995)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kinesin light chain 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:45860553-45860719 Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45872585-45873426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45878599-45879436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45879437-45880275 Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45894822-45895340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45895341-45895857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45901839-45902837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45908213-45909008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45923066-45923566 Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14796 Neighboring gene Sharpr-MPRA regulatory region 13779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10765 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45943151-45943650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10768 Neighboring gene microRNA 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45958106-45959072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45959073-45960039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45967946-45968446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45968447-45968947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45971355-45972256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14799 Neighboring gene FosB proto-oncogene, AP-1 transcription factor subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118851

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase I transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase I subunit RPA34
    Names
    CD3e antigen, epsilon polypeptide associated protein
    CD3e molecule associated protein
    CD3e molecule, epsilon associated protein
    DNA-directed RNA polymerase I subunit G
    RNA polymerase I-associated factor PAF49
    antisense to ERCC-1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297590.3NP_001284519.1  DNA-directed RNA polymerase I subunit RPA34 isoform 1

      See identical proteins and their annotated locations for NP_001284519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF017633, BU166593, U86751
      Consensus CDS
      CCDS74397.1
      UniProtKB/TrEMBL
      A8K818
      Related
      ENSP00000465099.1, ENST00000589804.1
      Conserved Domains (1) summary
      pfam08208
      Location:40180
      RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5
    2. NM_012099.3NP_036231.1  DNA-directed RNA polymerase I subunit RPA34 isoform 2

      See identical proteins and their annotated locations for NP_036231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      U86751
      Consensus CDS
      CCDS12661.1
      UniProtKB/Swiss-Prot
      O15446, Q32N11, Q7Z5U2, Q9UPF6
      UniProtKB/TrEMBL
      A8K818
      Related
      ENSP00000310966.3, ENST00000309424.8
      Conserved Domains (1) summary
      pfam08208
      Location:38178
      RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      45406644..45410737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48233891..48237984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)