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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_052962.1 RefSeqGene
- Range
-
4641..371503
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_007118.4 → NP_009049.2 triple functional domain protein
See identical proteins and their annotated locations for NP_009049.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
- Source sequence(s)
-
AC010419, AF091395, AI478154, AK131423, BC017268, BC035585, BF058117, BQ184284, BQ691537, U42390
- Consensus CDS
-
CCDS3883.1
- UniProtKB/Swiss-Prot
- D3DTD1, O75962, Q13458, Q59EQ7, Q6PJC9, Q6ZN05, Q8IWK8
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
- Related
- ENSP00000339299.4, ENST00000344204.9
- Conserved Domains (14) summary
-
- smart00150
Location:1143 → 1243
- SPEC; Spectrin repeats
- cd11852
Location:1659 → 1718
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2555 → 2613
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2796 → 3050
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:69 → 204
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1970 → 2143
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:567 → 783
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2685 → 2776
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1472 → 1594
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2148 → 2286
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- cd14113
Location:2788 → 3050
- STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
- pfam00169
Location:2175 → 2271
- PH; PH domain
- pfam16609
Location:1715 → 1972
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2699 → 2776
- Ig; Immunoglobulin domain
RNA
-
NR_134469.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC010419, AF091395, AI478154, AK131423, BC017268, BC035585, BF058117, BQ184284, BQ691537, U42390
- Related
-
ENST00000512070.6
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000005.10 Reference GRCh38.p14 Primary Assembly
- Range
-
14143342..14510204
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047417679.1 → XP_047273635.1 triple functional domain protein isoform X2
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_017009802.2 → XP_016865291.1 triple functional domain protein isoform X6
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
- Related
- ENSP00000426342.2, ENST00000513206.5
-
XM_017009801.2 → XP_016865290.1 triple functional domain protein isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_047417681.1 → XP_047273637.1 triple functional domain protein isoform X7
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_011514110.4 → XP_011512412.1 triple functional domain protein isoform X5
See identical proteins and their annotated locations for XP_011512412.1
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
- Conserved Domains (14) summary
-
- smart00150
Location:1084 → 1184
- SPEC; Spectrin repeats
- cd11852
Location:1600 → 1659
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2496 → 2554
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2737 → 2991
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:10 → 145
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1911 → 2084
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:508 → 724
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2626 → 2717
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1413 → 1535
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2089 → 2227
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- cd14113
Location:2729 → 2991
- STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
- pfam00169
Location:2116 → 2212
- PH; PH domain
- pfam16609
Location:1656 → 1913
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2640 → 2717
- Ig; Immunoglobulin domain
-
XM_011514108.2 → XP_011512410.1 triple functional domain protein isoform X3
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
- Conserved Domains (14) summary
-
- smart00150
Location:1104 → 1204
- SPEC; Spectrin repeats
- cd11852
Location:1620 → 1679
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2516 → 2574
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2757 → 3011
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:30 → 165
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1931 → 2104
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:528 → 744
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2646 → 2737
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1433 → 1555
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2109 → 2247
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- cd14113
Location:2749 → 3011
- STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
- pfam00169
Location:2136 → 2232
- PH; PH domain
- pfam16609
Location:1676 → 1933
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2660 → 2737
- Ig; Immunoglobulin domain
-
XM_011514109.4 → XP_011512411.1 triple functional domain protein isoform X4
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
- Conserved Domains (14) summary
-
- smart00150
Location:1094 → 1194
- SPEC; Spectrin repeats
- cd11852
Location:1610 → 1669
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2506 → 2564
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2747 → 3001
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:20 → 155
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1921 → 2094
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:518 → 734
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2636 → 2727
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1423 → 1545
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2099 → 2237
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- cd14113
Location:2739 → 3001
- STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
- pfam00169
Location:2126 → 2222
- PH; PH domain
- pfam16609
Location:1666 → 1923
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2650 → 2727
- Ig; Immunoglobulin domain
-
XM_011514107.3 → XP_011512409.1 triple functional domain protein isoform X2
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
- Conserved Domains (14) summary
-
- smart00150
Location:1122 → 1222
- SPEC; Spectrin repeats
- cd11852
Location:1638 → 1697
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2534 → 2592
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2775 → 3029
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:48 → 183
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1949 → 2122
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:546 → 762
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2664 → 2755
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1451 → 1573
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2127 → 2265
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- cd14113
Location:2767 → 3029
- STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
- pfam00169
Location:2154 → 2250
- PH; PH domain
- pfam16609
Location:1694 → 1951
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2678 → 2755
- Ig; Immunoglobulin domain
-
XM_017009803.2 → XP_016865292.1 triple functional domain protein isoform X8
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
Alternate T2T-CHM13v2.0
Genomic
-
NC_060929.1 Alternate T2T-CHM13v2.0
- Range
-
14080499..14449245
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054353386.1 → XP_054209361.1 triple functional domain protein isoform X2
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353390.1 → XP_054209365.1 triple functional domain protein isoform X6
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353385.1 → XP_054209360.1 triple functional domain protein isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353391.1 → XP_054209366.1 triple functional domain protein isoform X7
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353389.1 → XP_054209364.1 triple functional domain protein isoform X5
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353387.1 → XP_054209362.1 triple functional domain protein isoform X3
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353388.1 → XP_054209363.1 triple functional domain protein isoform X4
- UniProtKB/TrEMBL
-
A0A2X0SFJ0
-
XM_054353392.1 → XP_054209367.1 triple functional domain protein isoform X8
- UniProtKB/TrEMBL
-
A0A2X0SFJ0