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    CSF2RA colony stimulating factor 2 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 1438, updated on 27-Nov-2024

    Summary

    Official Symbol
    CSF2RAprovided by HGNC
    Official Full Name
    colony stimulating factor 2 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:2435
    See related
    Ensembl:ENSG00000198223 Ensembl:ENSG00000292357 MIM:306250; MIM:425000; AllianceGenome:HGNC:2435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; alphaGMR; GMR-alpha; GMCSFR-alpha; GM-CSF-R-alpha
    Summary
    The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 20.8), appendix (RPKM 7.7) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CSF2RA in Genome Data Viewer
    Location:
    X;Y
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1268814..1325218)
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1268814..1325218)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1116126..1174802)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1129416..1189240)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1387707..1444111)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1337707..1394111)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene hESC enhancers GRCh37_chrX:1324089-1324592, GRCh37_chrY:1274255-1275102 and GRCh37_chrY:1273405-1274254 Neighboring gene cytokine receptor like factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1367406-1367922 and GRCh37_chrY:1317424-1317933 Neighboring gene NANOG hESC enhancer GRCh37_chrY:1330085-1330594 Neighboring gene uncharacterized LOC124905238 Neighboring gene microRNA 3690 Neighboring gene RNA, 5S ribosomal pseudogene 498 Neighboring gene uncharacterized LOC101928032 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:1510270-1510865 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1510866-1511460 and GRCh37_chrY:1460904-1461506 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene solute carrier family 25 member 6

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene hESC enhancers GRCh37_chrX:1324089-1324592, GRCh37_chrY:1274255-1275102 and GRCh37_chrY:1273405-1274254 Neighboring gene cytokine receptor like factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1367406-1367922 and GRCh37_chrY:1317424-1317933 Neighboring gene NANOG hESC enhancer GRCh37_chrY:1330085-1330594 Neighboring gene uncharacterized LOC124905238 Neighboring gene microRNA 3690 Neighboring gene RNA, 5S ribosomal pseudogene 498 Neighboring gene uncharacterized LOC101928032 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:1510270-1510865 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1510866-1511460 and GRCh37_chrY:1460904-1461506 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene solute carrier family 25 member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Surfactant metabolism dysfunction, pulmonary, 4
    MedGen: C2677877 OMIM: 300770 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of colony stimulating factor 2 receptor, alpha subunit (CSF2RA) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3848, MGC4838

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of granulocyte macrophage colony-stimulating factor receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of growth hormone receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    granulocyte-macrophage colony-stimulating factor receptor subunit alpha
    Names
    CD116 antigen
    GM-CSF receptor alpha subunit
    alpha-GM-CSF receptor
    colony stimulating factor 2 receptor alpha subunit
    colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
    granulocyte-macrophage colony-stimulating factor receptor alpha chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012280.1 RefSeqGene

      Range
      5001..46136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_186

    mRNA and Protein(s)

    1. NM_001161529.2NP_001155001.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

      See identical proteins and their annotated locations for NP_001155001.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35191.1
      UniProtKB/Swiss-Prot
      A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
      Related
      ENSP00000416437.2, ENSP00000518633.1, ENST00000432318.8, ENST00000711131.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    2. NM_001161530.2NP_001155002.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

      See identical proteins and their annotated locations for NP_001155002.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS55359.1
      UniProtKB/Swiss-Prot
      P15509
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    3. NM_001161531.2NP_001155003.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor

      See identical proteins and their annotated locations for NP_001155003.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS55360.1
      UniProtKB/Swiss-Prot
      P15509
      Related
      ENSP00000370920.3, ENSP00000518632.1, ENST00000381509.8, ENST00000711220.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    4. NM_001161532.2NP_001155004.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform h

      See identical proteins and their annotated locations for NP_001155004.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      UniProtKB/Swiss-Prot
      P15509
      Conserved Domains (1) summary
      pfam09240
      Location:182
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    5. NM_001379153.1NP_001366082.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS55359.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    6. NM_001379154.1NP_001366083.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS55359.1
      Related
      ENSP00000512483.1, ENSP00000518638.1, ENST00000498153.7, ENST00000711138.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    7. NM_001379155.1NP_001366084.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS55360.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    8. NM_001379156.1NP_001366085.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35191.1
      UniProtKB/Swiss-Prot
      A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    9. NM_001379158.1NP_001366087.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35191.1
      UniProtKB/Swiss-Prot
      A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    10. NM_001379159.1NP_001366088.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform i precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553, BX901885
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    11. NM_001379160.1NP_001366089.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform j precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    12. NM_001379161.1NP_001366090.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform k precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553, BX901885
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    13. NM_001379162.1NP_001366091.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform l precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553, BX901885
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    14. NM_001379163.1NP_001366092.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform l precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553, BX901885
      Related
      ENSP00000520702.1, ENSP00000520930.1, ENST00000718262.1, ENST00000850691.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    15. NM_001379164.1NP_001366093.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform m precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553, BX901885
      Related
      ENSP00000520701.1, ENSP00000520929.1, ENST00000718261.1, ENST00000850690.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    16. NM_001379165.1NP_001366094.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform m precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553, BX901885
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    17. NM_001379166.1NP_001366095.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform n precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    18. NM_001379167.1NP_001366096.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35192.1
      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    19. NM_001379168.1NP_001366097.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35192.1
      UniProtKB/TrEMBL
      F2Z3C9
      Related
      ENSP00000370911.1, ENSP00000518627.1, ENST00000381500.6, ENST00000711226.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    20. NM_001379169.1NP_001366098.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35192.1
      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    21. NM_006140.6NP_006131.2  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

      See identical proteins and their annotated locations for NP_006131.2

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35191.1
      UniProtKB/Swiss-Prot
      A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
      Related
      ENSP00000370935.3, ENSP00000518637.1, ENST00000381524.8, ENST00000711137.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    22. NM_172245.4NP_758448.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

      See identical proteins and their annotated locations for NP_758448.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35191.1
      UniProtKB/Swiss-Prot
      A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
      Related
      ENSP00000370940.3, ENSP00000518635.1, ENST00000381529.9, ENST00000711129.1
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    23. NM_172246.4NP_758449.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35190.1
      UniProtKB/Swiss-Prot
      P15509
      Related
      ENSP00000347606.3, ENSP00000518630.1, ENST00000355432.8, ENST00000711223.1
      Conserved Domains (2) summary
      smart00060
      Location:220298
      FN3; Fibronectin type 3 domain
      pfam09240
      Location:121215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    24. NM_172247.3NP_758450.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

      See identical proteins and their annotated locations for NP_758450.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35192.1
      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    25. NM_172249.4NP_758452.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform e precursor

      See identical proteins and their annotated locations for NP_758452.1

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Consensus CDS
      CCDS35193.1
      UniProtKB/TrEMBL
      J3JS74
      Related
      ENSP00000348058.2, ENSP00000518629.1, ENST00000355805.7, ENST00000711224.1
      Conserved Domains (1) summary
      pfam09240
      Location:121215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RNA

    1. NR_027760.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BX649553
      Related
      ENST00000486791.6, ENST00000711225.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      1268814..1325218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441851.1XP_047297807.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

      Related
      ENSP00000520699.1, ENST00000718259.1
    2. XM_011546175.3XP_011544477.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

      See identical proteins and their annotated locations for XP_011544477.1

      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    3. XM_047441850.1XP_047297806.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    4. XM_011546167.3XP_011544469.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_011544469.1

      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    5. XM_011546174.4XP_011544476.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

      See identical proteins and their annotated locations for XP_011544476.1

      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    6. XM_047441853.1XP_047297809.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    7. XM_047441846.1XP_047297802.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    8. XM_047441847.1XP_047297803.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    9. XM_047441845.1XP_047297801.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    10. XM_047441849.1XP_047297805.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

    11. XM_047441848.1XP_047297804.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    12. XM_047441852.1XP_047297808.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      1268814..1325218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442716.1XP_047298672.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

      Related
      ENSP00000520927.1, ENST00000850688.1
    2. XM_011545628.3XP_011543930.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

      See identical proteins and their annotated locations for XP_011543930.1

      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    3. XM_047442715.1XP_047298671.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    4. XM_011545620.3XP_011543922.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_011543922.1

      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    5. XM_011545627.4XP_011543929.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

      See identical proteins and their annotated locations for XP_011543929.1

      UniProtKB/TrEMBL
      F2Z3C9
      Conserved Domains (2) summary
      pfam09240
      Location:123215
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:35112
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    6. XM_047442718.1XP_047298674.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    7. XM_047442711.1XP_047298667.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    8. XM_047442712.1XP_047298668.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    9. XM_047442710.1XP_047298666.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    10. XM_047442714.1XP_047298670.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

    11. XM_047442713.1XP_047298669.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    12. XM_047442717.1XP_047298673.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      1116126..1174802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326521.1XP_054182496.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

    2. XM_054326525.1XP_054182500.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    3. XM_054326520.1XP_054182495.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    4. XM_054326515.1XP_054182490.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    5. XM_054326523.1XP_054182498.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    6. XM_054326524.1XP_054182499.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    7. XM_054326514.1XP_054182489.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    8. XM_054326516.1XP_054182491.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    9. XM_054326517.1XP_054182492.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    10. XM_054326519.1XP_054182494.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

    11. XM_054326518.1XP_054182493.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    12. XM_054326522.1XP_054182497.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      1129416..1189240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328251.1XP_054184226.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    2. XM_054328247.1XP_054184222.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    3. XM_054328242.1XP_054184217.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    4. XM_054328249.1XP_054184224.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    5. XM_054328250.1XP_054184225.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    6. XM_054328241.1XP_054184216.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    7. XM_054328243.1XP_054184218.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    8. XM_054328244.1XP_054184219.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    9. XM_054328246.1XP_054184221.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

    10. XM_054328245.1XP_054184220.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    11. XM_054328248.1XP_054184223.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172248.1: Suppressed sequence

      Description
      NM_172248.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.