U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    EXOC7 exocyst complex component 7 [ Homo sapiens (human) ]

    Gene ID: 23265, updated on 3-Dec-2024

    Summary

    Official Symbol
    EXOC7provided by HGNC
    Official Full Name
    exocyst complex component 7provided by HGNC
    Primary source
    HGNC:HGNC:23214
    See related
    Ensembl:ENSG00000182473 MIM:608163; AllianceGenome:HGNC:23214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLOM4; EX070; EXO70; EXOC1; 2-5-3p; Exo70p; NEDSEBA; YJL085W
    Summary
    The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in prostate (RPKM 23.4), brain (RPKM 22.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EXOC7 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76081016..76103787, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76977586..77000348, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74077097..74099868, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene envoplakin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74022969-74023856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74030076-74030683 Neighboring gene Sharpr-MPRA regulatory region 345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74036239-74036940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74036941-74037642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9001 Neighboring gene signal recognition particle 68 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74067885-74068712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74068713-74069540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74070927-74071808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74072691-74073571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74075097-74076094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74076095-74077090 Neighboring gene MPRA-validated peak3003 silencer Neighboring gene galanin receptor 2 Neighboring gene zinc activated ion channel Neighboring gene microRNA 6868 Neighboring gene uncharacterized LOC101928447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74127821-74128482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74128483-74129142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133109-74133770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133771-74134430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74135093-74135752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9005 Neighboring gene RNF157 antisense RNA 1 Neighboring gene forkhead box J1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40965, FLJ46415, DKFZp686J04253

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in growth cone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    exocyst complex component 7
    Names
    exocyst complex component Exo70

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030672.1 RefSeqGene

      Range
      5001..27772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001013839.4NP_001013861.1  exocyst complex component 7 isoform 1

      See identical proteins and their annotated locations for NP_001013861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB028990, AI653861, BC011045, BX647763
      Consensus CDS
      CCDS32738.1
      UniProtKB/TrEMBL
      Q5G0E1
      Related
      ENSP00000468404.1, ENST00000589210.6
      Conserved Domains (1) summary
      pfam03081
      Location:319678
      Exo70; Exo70 exocyst complex subunit
    2. NM_001145297.4NP_001138769.1  exocyst complex component 7 isoform 4

      See identical proteins and their annotated locations for NP_001138769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate in-frame exon resulting in a longer protein (isoform 4) compared to isoform 1.
      Source sequence(s)
      AB028990, AI653861, BC018466, BX647763
      Consensus CDS
      CCDS45782.1
      UniProtKB/Swiss-Prot
      B5MC69, B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32, Q9UPT5
      UniProtKB/TrEMBL
      Q5G0E1
      Related
      ENSP00000334100.6, ENST00000335146.11
      Conserved Domains (1) summary
      pfam03081
      Location:370729
      Exo70; Exo70 exocyst complex subunit
    3. NM_001145298.4NP_001138770.1  exocyst complex component 7 isoform 5

      See identical proteins and their annotated locations for NP_001138770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) omits an in-frame coding exon and includes an alternate in-frame coding exon compared to variant 1. The predicted protein (isoform 5) is shorter than isoform 1.
      Source sequence(s)
      AB028990, AI653861, BX647763, FJ457119
      Consensus CDS
      CCDS45781.1
      UniProtKB/TrEMBL
      Q5G0E1
      Related
      ENSP00000404322.2, ENST00000411744.6
      Conserved Domains (1) summary
      pfam03081
      Location:311670
      Exo70; Exo70 exocyst complex subunit
    4. NM_001145299.4NP_001138771.1  exocyst complex component 7 isoform 6

      See identical proteins and their annotated locations for NP_001138771.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) includes an alternate in-frame coding exon, compared to variant 1, resulting in a longer protein isoform (6).
      Source sequence(s)
      AB028990, AI653861, BX647763, FJ457120
      Consensus CDS
      CCDS45783.1
      UniProtKB/TrEMBL
      Q5G0E1
      Related
      ENSP00000489266.1, ENST00000634349.1
      Conserved Domains (1) summary
      pfam03081
      Location:342701
      Exo70; Exo70 exocyst complex subunit
    5. NM_001282313.2NP_001269242.1  exocyst complex component 7 isoform 3

      See identical proteins and their annotated locations for NP_001269242.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG, and the resulting isoform (3) has a shorter N-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      AB028990, AI653861, AK295871, BX647763, DC319923
      Consensus CDS
      CCDS45784.1
      UniProtKB/TrEMBL
      B4DJ07, Q5G0E1
      Related
      ENSP00000466682.1, ENST00000467929.6
      Conserved Domains (1) summary
      pfam03081
      Location:278650
      Exo70; Exo70 exocyst complex subunit
    6. NM_001282314.2NP_001269243.1  exocyst complex component 7 isoform 7

      See identical proteins and their annotated locations for NP_001269243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks several 3' exons but contains an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus compared with isoform 1.
      Source sequence(s)
      AA215645, AC018665, BC029432, HY020675
      Consensus CDS
      CCDS74164.1
      UniProtKB/TrEMBL
      B5MCY9, K7ERQ5
      Related
      ENSP00000385066.3, ENST00000406660.4
    7. NM_001375974.1NP_001362903.1  exocyst complex component 7 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC018665
      UniProtKB/TrEMBL
      Q5G0E1
      Conserved Domains (1) summary
      pfam03081
      Location:313691
      Exo70; Exo70 exocyst complex subunit
    8. NM_001375975.1NP_001362904.1  exocyst complex component 7 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC018665
      UniProtKB/TrEMBL
      Q63HP7
      Conserved Domains (1) summary
      pfam03081
      Location:282660
      Exo70; Exo70 exocyst complex subunit
    9. NM_001375976.1NP_001362905.1  exocyst complex component 7 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018665
      UniProtKB/TrEMBL
      Q5G0E1
      Conserved Domains (1) summary
      pfam03081
      Location:336714
      Exo70; Exo70 exocyst complex subunit
    10. NM_015219.5NP_056034.2  exocyst complex component 7 isoform 2

      See identical proteins and their annotated locations for NP_056034.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB028990, AI653861, AK023832, BX647763
      Consensus CDS
      CCDS11741.1
      UniProtKB/TrEMBL
      Q63HP7
      Related
      ENSP00000333806.4, ENST00000332065.9
      Conserved Domains (1) summary
      pfam03081
      Location:288647
      Exo70; Exo70 exocyst complex subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76081016..76103787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721788.5XP_006721851.1  exocyst complex component 7 isoform X1

      See identical proteins and their annotated locations for XP_006721851.1

      UniProtKB/TrEMBL
      Q5G0E1
      Conserved Domains (1) summary
      pfam03081
      Location:311683
      Exo70; Exo70 exocyst complex subunit
    2. XM_047435690.1XP_047291646.1  exocyst complex component 7 isoform X2

    3. XM_047435691.1XP_047291647.1  exocyst complex component 7 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76977586..77000348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315596.1XP_054171571.1  exocyst complex component 7 isoform X1

      UniProtKB/TrEMBL
      Q5G0E1
    2. XM_054315597.1XP_054171572.1  exocyst complex component 7 isoform X2

    3. XM_054315598.1XP_054171573.1  exocyst complex component 7 isoform X3