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    KRT6B keratin 6B [ Homo sapiens (human) ]

    Gene ID: 3854, updated on 9-Dec-2024

    Summary

    Official Symbol
    KRT6Bprovided by HGNC
    Official Full Name
    keratin 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:6444
    See related
    Ensembl:ENSG00000185479 MIM:148042; AllianceGenome:HGNC:6444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K6B; PC2; PC4; CK6B; CK-6B; KRTL1
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward esophagus (RPKM 785.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KRT6B in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52446651..52452146, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52411258..52416753, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52840435..52845930, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 90, pseudogene Neighboring gene keratin 75 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52831010-52831512 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:52835896-52837095 Neighboring gene keratin 6C Neighboring gene keratin 6A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ectoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 6B
    Names
    cytokeratin 6B
    keratin 6B, type II
    keratin, epidermal, type II, K6B
    keratin-like 1 (a type II keratin sequence)
    type-II keratin Kb10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008299.1 RefSeqGene

      Range
      4981..10476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005555.4NP_005546.2  keratin, type II cytoskeletal 6B

      See identical proteins and their annotated locations for NP_005546.2

      Status: REVIEWED

      Source sequence(s)
      AC055736, BC034535, BG679927
      Consensus CDS
      CCDS8828.1
      UniProtKB/Swiss-Prot
      P04259, P48669
      UniProtKB/TrEMBL
      A8K2I0, B2R853
      Related
      ENSP00000252252.3, ENST00000252252.4
      Conserved Domains (2) summary
      pfam00038
      Location:162475
      Filament; Intermediate filament protein
      pfam16208
      Location:17159
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52446651..52452146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52411258..52416753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)