U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 [ Homo sapiens (human) ]

    Gene ID: 783, updated on 3-Dec-2024

    Summary

    Official Symbol
    CACNB2provided by HGNC
    Official Full Name
    calcium voltage-gated channel auxiliary subunit beta 2provided by HGNC
    Primary source
    HGNC:HGNC:1402
    See related
    Ensembl:ENSG00000165995 MIM:600003; AllianceGenome:HGNC:1402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAB2; MYSB; CAVB2; CACNLB2
    Summary
    This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
    Expression
    Ubiquitous expression in brain (RPKM 4.0), adrenal (RPKM 2.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CACNB2 in Genome Data Viewer
    Location:
    10p12.33-p12.31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (18140424..18543557)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (18159755..18562802)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18429353..18832486)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902600 Neighboring gene mannose receptor C-type 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:18270087-18271286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3111 Neighboring gene solute carrier family 39 member 12 Neighboring gene SLC39A12 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:18324740-18325329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:18325330-18325918 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:18355421-18356620 Neighboring gene MPRA-validated peak890 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr10:18424852-18425818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11486 Neighboring gene uncharacterized LOC107984213 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:18629448-18629653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3112 Neighboring gene uncharacterized LOC124902386 Neighboring gene uncharacterized LOC124902387 Neighboring gene NANOG hESC enhancer GRCh37_chr10:18841481-18841982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3113 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2184 Neighboring gene ARF like GTPase 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Brugada syndrome 4
    MedGen: C2678477 OMIM: 611876 GeneReviews: Brugada Syndrome
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study of blood pressure and hypertension.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog
    Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23743

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane depolarization during AV node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane depolarization during atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular junction development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of high voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of muscle contraction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of heart rate by cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of L-type voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of L-type voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in photoreceptor ribbon synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-2
    Names
    calcium channel voltage-dependent subunit beta 2
    calcium channel, voltage-dependent, beta 2 subunit
    lambert-Eaton myasthenic syndrome antigen B
    myasthenic (Lambert-Eaton) syndrome antigen B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016195.1 RefSeqGene

      Range
      4748..407881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_381

    mRNA and Protein(s)

    1. NM_000724.4NP_000715.2  voltage-dependent L-type calcium channel subunit beta-2 isoform 1

      See identical proteins and their annotated locations for NP_000715.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (1) with a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AB208917, AL390783, AL450384
      Consensus CDS
      CCDS7128.1
      UniProtKB/TrEMBL
      Q59H42
      Related
      ENSP00000379821.2, ENST00000396576.6
      Conserved Domains (4) summary
      cd12040
      Location:57125
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam12052
      Location:1758
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      pfam12782
      Location:483576
      Innate_immun; Invertebrate innate immunity transcript family
      cl27059
      Location:225405
      Guanylate_kin; Guanylate kinase
    2. NM_001167945.2NP_001161417.1  voltage-dependent L-type calcium channel subunit beta-2 isoform 9

      See identical proteins and their annotated locations for NP_001161417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate 5' terminal exon, lacks an alternate in-frame exon and contains an alternate in-frame exon in the 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (9) with a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AK307526, AL360231, AL450384
      UniProtKB/TrEMBL
      A0A2R8Y555
      Related
      ENSP00000494209.2, ENST00000643096.2
      Conserved Domains (3) summary
      cd12040
      Location:84152
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:214394
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:4485
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    3. NM_001330060.2NP_001316989.1  voltage-dependent L-type calcium channel subunit beta-2 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and uses an alternate internal in-frame exon compared to variant 2. These differences cause translation initiation at an alternate start codon and result in an isoform (10) that is shorter and has a distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AF465485, AL390783, AL450384, BP311576
      Consensus CDS
      CCDS81442.1
      UniProtKB/TrEMBL
      A0A087WVX5
      Related
      ENSP00000366536.3, ENST00000377319.9
      Conserved Domains (4) summary
      cd12040
      Location:57125
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam12052
      Location:1758
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      pfam12782
      Location:445538
      Innate_immun; Invertebrate innate immunity transcript family
      cl27059
      Location:187367
      Guanylate_kin; Guanylate kinase
    4. NM_001410882.1NP_001397811.1  voltage-dependent L-type calcium channel subunit beta-2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL139814, AL450364, AL450384
      Consensus CDS
      CCDS91220.1
      UniProtKB/TrEMBL
      A0A494C0B2, B7Z1U5
      Related
      ENSP00000498460.1, ENST00000650685.1
    5. NM_201570.3NP_963864.1  voltage-dependent L-type calcium channel subunit beta-2 isoform 7

      See identical proteins and their annotated locations for NP_963864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (7) with a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AF423192, AL139814, AL450384
      Consensus CDS
      CCDS7129.1
      UniProtKB/TrEMBL
      B7Z1U5, Q5VVH1
      Related
      ENSP00000366532.4, ENST00000377315.6
      Conserved Domains (4) summary
      cd12040
      Location:64132
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:232412
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:2465
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      pfam12782
      Location:490583
      Innate_immun; Invertebrate innate immunity transcript family
    6. NM_201571.4NP_963865.2  voltage-dependent L-type calcium channel subunit beta-2 isoform 6

      See identical proteins and their annotated locations for NP_963865.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' terminal exon and therefore differs in the 5' UTR and 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (6) with a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AF423190, AL360231, AL450384, DC307859, DC352526
      Consensus CDS
      CCDS7127.1
      UniProtKB/TrEMBL
      B7Z3Y0
      Related
      ENSP00000282343.8, ENST00000282343.13
      Conserved Domains (3) summary
      cd12040
      Location:84152
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:252432
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:4485
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    7. NM_201572.4NP_963866.2  voltage-dependent L-type calcium channel subunit beta-2 isoform 8

      See identical proteins and their annotated locations for NP_963866.2

      Status: REVIEWED

      Description
      Transcript Variant:This variant (8) uses an alternate 5' terminal exon, lacks an alternate in-frame exon and contains an alternate in-frame exon in the 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (8) with a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AL360231, AL450384, AY393861, DC307859, DC352526
      Consensus CDS
      CCDS41493.1
      UniProtKB/TrEMBL
      A0A2R8Y555
      Related
      ENSP00000496203.1, ENST00000645287.2
      Conserved Domains (4) summary
      cd12040
      Location:84152
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam12052
      Location:4485
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      pfam12782
      Location:486579
      Innate_immun; Invertebrate innate immunity transcript family
      cl27059
      Location:228408
      Guanylate_kin; Guanylate kinase
    8. NM_201590.3NP_963884.2  voltage-dependent L-type calcium channel subunit beta-2 isoform 3

      See identical proteins and their annotated locations for NP_963884.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 2. These differences cause translation initiation at an alternate start codon, and result in an isoform (3) with a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AL450384, AY393859, DB235418
      Consensus CDS
      CCDS41494.1
      UniProtKB/TrEMBL
      Q59H42
      Related
      ENSP00000366546.4, ENST00000377329.10
      Conserved Domains (4) summary
      cd12040
      Location:58126
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam12052
      Location:1859
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      pfam12782
      Location:484577
      Innate_immun; Invertebrate innate immunity transcript family
      cl27059
      Location:226406
      Guanylate_kin; Guanylate kinase
    9. NM_201593.3NP_963887.2  voltage-dependent L-type calcium channel subunit beta-2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and contains an alternate in-frame exon, in the 5' coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.
      Source sequence(s)
      AF465485, AL119895, AL360231, AL450384, S60415
      UniProtKB/TrEMBL
      A0A2R8Y555
      Conserved Domains (4) summary
      cd12040
      Location:112180
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:242422
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:72113
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:252423
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    10. NM_201596.3NP_963890.2  voltage-dependent L-type calcium channel subunit beta-2 isoform 2

      See identical proteins and their annotated locations for NP_963890.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AL360231, AL450384, S60415
      Consensus CDS
      CCDS7125.1
      UniProtKB/Swiss-Prot
      A6PVM5, A6PVM7, A6PVM8, O00304, Q08289, Q5QJ99, Q5QJA0, Q5VVG9, Q5VVH0, Q5VWV6, Q6TME1, Q6TME2, Q6TME3, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341
      UniProtKB/TrEMBL
      B7Z3Y0
      Related
      ENSP00000320025.8, ENST00000324631.13
      Conserved Domains (4) summary
      cd12040
      Location:112180
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:280460
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:72113
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:290461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    11. NM_201597.3NP_963891.1  voltage-dependent L-type calcium channel subunit beta-2 isoform 4

      See identical proteins and their annotated locations for NP_963891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains an alternate in-frame exon, in the 5' coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2.
      Source sequence(s)
      AL360231, AL450384, AY393860, S60415
      Consensus CDS
      CCDS7126.1
      UniProtKB/TrEMBL
      B7Z3Y0
      Related
      ENSP00000344474.6, ENST00000352115.10
      Conserved Domains (4) summary
      cd12040
      Location:112180
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:256436
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:72113
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:266437
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      18140424..18543557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425725.1XP_047281681.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X4

      UniProtKB/TrEMBL
      A0A2R8YFX9
      Related
      ENSP00000495509.1, ENST00000644004.1
    2. XM_011519659.3XP_011517961.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X2

      See identical proteins and their annotated locations for XP_011517961.1

      UniProtKB/TrEMBL
      A0A087WVX5
      Conserved Domains (4) summary
      cd12040
      Location:58126
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:202382
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:1859
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:212383
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. XM_006717502.4XP_006717565.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006717565.1

      UniProtKB/TrEMBL
      A0A494C184, Q59H42
      Related
      ENSP00000498938.1, ENST00000652391.1
      Conserved Domains (4) summary
      cd12040
      Location:52120
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:220400
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:1253
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:230401
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. XM_005252591.4XP_005252648.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_005252648.1

      Conserved Domains (2) summary
      pfam00625
      Location:1180
      Guanylate_kin; Guanylate kinase
      cl17190
      Location:10181
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      18159755..18562802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366706.1XP_054222681.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X4

      UniProtKB/TrEMBL
      A0A2R8YFX9
    2. XM_054366704.1XP_054222679.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A0A087WVX5
    3. XM_054366703.1XP_054222678.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A494C184, Q59H42
    4. XM_054366705.1XP_054222680.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X3