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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008996.1 RefSeqGene
- Range
-
5001..130982
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_662
mRNA and Protein(s)
-
NM_000245.4 → NP_000236.2 hepatocyte growth factor receptor isoform b preproprotein
See identical proteins and their annotated locations for NP_000236.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
- Source sequence(s)
-
AA278232, AC002080, BX648782, DB223186, X54559
- Consensus CDS
-
CCDS43636.1
- UniProtKB/Swiss-Prot
- A1L467, B5A932, E7EQ94, O60366, P08581, Q12875, Q9UDX7, Q9UPL8
- Related
- ENSP00000380860.3, ENST00000397752.8
- Conserved Domains (7) summary
-
- cd11278
Location:25 → 516
- Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
- smart00423
Location:519 → 561
- PSI; domain found in Plexins, Semaphorins and Integrins
- smart00429
Location:838 → 934
- IPT; ig-like, plexins, transcription factors
- cd01179
Location:657 → 740
- IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:563 → 656
- IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01181
Location:742 → 837
- IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd05058
Location:1082 → 1343
- PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
-
NM_001127500.3 → NP_001120972.1 hepatocyte growth factor receptor isoform a preproprotein
See identical proteins and their annotated locations for NP_001120972.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AC002080, AC002543, BC130420, BX648782, DB223186, J02958
- Consensus CDS
-
CCDS47689.1
- Related
- ENSP00000317272.6, ENST00000318493.11
- Conserved Domains (8) summary
-
- cd11278
Location:25 → 516
- Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
- smart00423
Location:519 → 561
- PSI; domain found in Plexins, Semaphorins and Integrins
- smart00429
Location:856 → 952
- IPT; ig-like, plexins, transcription factors
- cd01179
Location:657 → 740
- IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:563 → 656
- IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd05058
Location:1100 → 1361
- PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
- pfam07714
Location:1096 → 1355
- Pkinase_Tyr; Protein tyrosine kinase
- cl15674
Location:742 → 855
- IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
-
NM_001324401.3 → NP_001311330.1 hepatocyte growth factor receptor isoform c precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) encodes isoform c, which lacks a portion of the beta subunit.
- Source sequence(s)
-
AC002080, DB223186, EU176015
- UniProtKB/TrEMBL
- B5A929, E6Y365, H7C174
- Related
- ENSP00000398776.2, ENST00000422097.2
- Conserved Domains (6) summary
-
- cd11278
Location:25 → 516
- Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
- smart00423
Location:519 → 561
- PSI; domain found in Plexins, Semaphorins and Integrins
- smart00429
Location:838 → 918
- IPT; ig-like, plexins, transcription factors
- cd01179
Location:657 → 740
- IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:563 → 656
- IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cl15674
Location:742 → 837
- IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
-
NM_001324402.2 → NP_001311331.1 hepatocyte growth factor receptor isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) encodes isoform d, which lacks a predicted signal peptide compared to isoforms a-c.
- Source sequence(s)
-
AC002080, AC002543, AC004416, AI630755
- UniProtKB/TrEMBL
-
B4DLF5
- Conserved Domains (8) summary
-
- smart00423
Location:89 → 131
- PSI; domain found in Plexins, Semaphorins and Integrins
- smart00429
Location:408 → 504
- IPT; ig-like, plexins, transcription factors
- cd01179
Location:227 → 310
- IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:133 → 226
- IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd05058
Location:652 → 913
- PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
- pfam07714
Location:648 → 907
- Pkinase_Tyr; Protein tyrosine kinase
- cl15674
Location:312 → 407
- IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
- cl15693
Location:1 → 86
- Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000007.14 Reference GRCh38.p14 Primary Assembly
- Range
-
116672196..116798377
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011516223.2 → XP_011514525.1 hepatocyte growth factor receptor isoform X1
- Conserved Domains (8) summary
-
- cd11278
Location:44 → 535
- Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
- smart00423
Location:538 → 580
- PSI; domain found in Plexins, Semaphorins and Integrins
- smart00429
Location:857 → 953
- IPT; ig-like, plexins, transcription factors
- cd01179
Location:676 → 759
- IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:582 → 675
- IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01181
Location:761 → 856
- IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd05058
Location:1101 → 1362
- PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
- pfam07714
Location:1097 → 1356
- Pkinase_Tyr; Protein tyrosine kinase
-
XM_047420400.1 → XP_047276356.1 hepatocyte growth factor receptor isoform X2
- UniProtKB/TrEMBL
-
B5A931
- Related
- ENSP00000410980.2, ENST00000436117.3
Alternate T2T-CHM13v2.0
Genomic
-
NC_060931.1 Alternate T2T-CHM13v2.0
- Range
-
117987305..118113574
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054358255.1 → XP_054214230.1 hepatocyte growth factor receptor isoform X1
-
XM_054358256.1 → XP_054214231.1 hepatocyte growth factor receptor isoform X2
- UniProtKB/TrEMBL
-
B5A931