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    CHRM3 cholinergic receptor muscarinic 3 [ Homo sapiens (human) ]

    Gene ID: 1131, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CHRM3provided by HGNC
    Official Full Name
    cholinergic receptor muscarinic 3provided by HGNC
    Primary source
    HGNC:HGNC:1952
    See related
    Ensembl:ENSG00000133019 MIM:118494; AllianceGenome:HGNC:1952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HM3; PBS; EGBRS; m3AChR
    Summary
    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHRM3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (239386568..239915450)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (238798998..239328607)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (239549868..240078750)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904566 Neighboring gene uncharacterized LOC105373223 Neighboring gene Sharpr-MPRA regulatory region 1169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:239550590-239551090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:239551091-239551591 Neighboring gene uncharacterized LOC105373225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:239869465-239869994 Neighboring gene CHRM3 antisense RNA 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:239973609-239974110 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:239974613-239975113 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:239974111-239974612 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:239973107-239973608 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:239977657-239978198 Neighboring gene NANOG hESC enhancer GRCh37_chr1:239996955-239997498 Neighboring gene uncharacterized LOC124904567 Neighboring gene uncharacterized LOC105373224 Neighboring gene CHRM3 antisense RNA 1 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) pseudogene Neighboring gene ribosomal protein S7 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans. Bharucha AE, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jul. PMID 20395537, Free PMC Article
    2. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Hur K, et al. Gut, 2014 Apr. PMID 23704319, Free PMC Article
    3. Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. Sawada Y, et al. J Invest Dermatol, 2010 Nov. PMID 20613776
    4. High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer. Wu J, et al. Tumour Biol, 2013 Dec. PMID 23838802
    5. Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. Asahina M, et al. Intern Med, 2013. PMID 24334576

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families.
      Title: The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families.
    2. Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.
      Title: Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.
    3. Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?
      Title: Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?
    4. CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.
      Title: CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.
    5. Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.
      Title: Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.
    6. Expression of M3 muscarinic acetylcholine receptors in gastric cancer.
      Title: Expression of M3 muscarinic acetylcholine receptors in gastric cancer.
    7. Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ETdagger.
      Title: Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.
    8. Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma.
      Title: Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma.
    9. M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjogren's syndrome.
      Title: M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjögren's syndrome.
    10. Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
      Title: Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
    Submit: New GeneRIF Correction See all GeneRIFs (131)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Prune belly syndrome
    MedGen: C0033770 OMIM: 100100 GeneReviews: Not available
    		not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2023-11-16)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2023-11-16)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    EBI GWAS Catalog
    Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    EBI GWAS Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CHRM3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled acetylcholine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acetylcholine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ligand-gated ion channel signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in saliva secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    muscarinic acetylcholine receptor M3
    Names
    acetylcholine receptor, muscarinic 3
    m3 muscarinic receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032046.2 RefSeqGene

      Range
      4639..533521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000740.4 → NP_000731.1  muscarinic acetylcholine receptor M3

      See identical proteins and their annotated locations for NP_000731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein. The 5' end of this transcript contains L1 element sequence, initiates from an L1 element promoter and expression was predominantly found in placenta. (PMID: 19669628)
      Source sequence(s)
      AF279779, AL356361, AL357499, BQ772140
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Related
      ENSP00000255380.4, ENST00000255380.8
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001347716.2 → NP_001334645.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer variant. Both variants 1 and 2 encode the same protein. The 5' end of this transcript contains long terminal repeat (LTR) sequence, initiates from an LTR promoter and expression was predominantly found in testis. (PMID: 19669628)
      Source sequence(s)
      AC099564, AC104460, AL356361, AL357499, AL513543, BQ772140
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001375978.1 → NP_001362907.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL357499, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Related
      ENSP00000502667.1, ENST00000676153.1
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. NM_001375979.1 → NP_001362908.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. NM_001375980.1 → NP_001362909.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. NM_001375981.1 → NP_001362910.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL357499, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. NM_001375982.1 → NP_001362911.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL357499, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Related
      ENSP00000502349.1, ENST00000675184.1
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. NM_001375983.1 → NP_001362912.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    9. NM_001375984.1 → NP_001362913.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL357499, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    10. NM_001375985.1 → NP_001362914.1  muscarinic acetylcholine receptor M3

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL356361, AL513543
      Consensus CDS
      CCDS1616.1
      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. NR_164748.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC099564, AC104460, AL357499, AL513543
      Related
      ENST00000468573.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      239386568..239915450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443115.1 → XP_047299071.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    2. XM_047443164.1 → XP_047299120.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    3. XM_011544043.3 → XP_011542345.1  muscarinic acetylcholine receptor M3 isoform X1

      See identical proteins and their annotated locations for XP_011542345.1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_011544044.3 → XP_011542346.1  muscarinic acetylcholine receptor M3 isoform X1

      See identical proteins and their annotated locations for XP_011542346.1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_011544047.3 → XP_011542349.1  muscarinic acetylcholine receptor M3 isoform X1

      See identical proteins and their annotated locations for XP_011542349.1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_047443128.1 → XP_047299084.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    7. XM_017000159.2 → XP_016855648.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. XM_047443148.1 → XP_047299104.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    9. XM_047443223.1 → XP_047299179.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    10. XM_047443157.1 → XP_047299113.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    11. XM_047443178.1 → XP_047299134.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    12. XM_017000162.2 → XP_016855651.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    13. XM_047443199.1 → XP_047299155.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    14. XM_047443206.1 → XP_047299162.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    15. XM_047443244.1 → XP_047299200.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    16. XM_047443119.1 → XP_047299075.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Related
      ENSP00000482377.1, ENST00000615928.5

    17. XM_017000152.3 → XP_016855641.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    18. XM_017000154.2 → XP_016855643.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    19. XM_017000157.3 → XP_016855646.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    20. XM_047443239.1 → XP_047299195.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    21. XM_017000160.3 → XP_016855649.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    22. XM_017000163.3 → XP_016855652.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 512
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      238798998..239328607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334025.1 → XP_054190000.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    2. XM_054334031.1 → XP_054190006.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    3. XM_054334024.1 → XP_054189999.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    4. XM_054334023.1 → XP_054189998.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    5. XM_054334027.1 → XP_054190002.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    6. XM_054334028.1 → XP_054190003.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    7. XM_054334034.1 → XP_054190009.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    8. XM_054334029.1 → XP_054190004.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    9. XM_054334041.1 → XP_054190016.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    10. XM_054334030.1 → XP_054190005.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    11. XM_054334032.1 → XP_054190007.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    12. XM_054334039.1 → XP_054190014.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    13. XM_054334036.1 → XP_054190011.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    14. XM_054334037.1 → XP_054190012.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    15. XM_054334043.1 → XP_054190018.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    16. XM_054334026.1 → XP_054190001.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    17. XM_054334033.1 → XP_054190008.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    18. XM_054334038.1 → XP_054190013.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    19. XM_054334042.1 → XP_054190017.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    20. XM_054334035.1 → XP_054190010.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9

    21. XM_054334040.1 → XP_054190015.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
      UniProtKB/TrEMBL
      Q96RG9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20309.1 GenPept UniProtKB/Swiss-Prot:P20309

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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