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    KRT3 keratin 3 [ Homo sapiens (human) ]

    Gene ID: 3850, updated on 9-Dec-2024

    Summary

    Official Symbol
    KRT3provided by HGNC
    Official Full Name
    keratin 3provided by HGNC
    Primary source
    HGNC:HGNC:6440
    See related
    Ensembl:ENSG00000186442 MIM:148043; AllianceGenome:HGNC:6440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K3; CK3; MECD2
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See KRT3 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52789685..52796117, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52754139..52770193, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53183469..53189901, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 2 binding protein pseudogene 2 Neighboring gene keratin 76 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:53184490-53185689 Neighboring gene MPRA-validated peak1735 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53206971-53207472 Neighboring gene keratin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53212003-53212504 Neighboring gene keratin 79

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ95909

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intermediate filament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratin filament TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 3
    Names
    65 kDa cytokeratin
    CK-3
    cytokeratin 3
    keratin 3, type II
    type-II keratin Kb3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008350.1 RefSeqGene

      Range
      4992..11424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057088.3NP_476429.2  keratin, type II cytoskeletal 3

      See identical proteins and their annotated locations for NP_476429.2

      Status: REVIEWED

      Source sequence(s)
      AC107016, AJ628418, BM672628, CV571376
      Consensus CDS
      CCDS44895.1
      UniProtKB/Swiss-Prot
      A6NIS2, P12035, Q701L8
      Related
      ENSP00000413479.2, ENST00000417996.2
      Conserved Domains (3) summary
      pfam00038
      Location:197512
      Filament; Intermediate filament protein
      pfam16208
      Location:170194
      Keratin_2_head; Keratin type II head
      cl23720
      Location:425486
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52789685..52796117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52754139..52770193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372016.1XP_054227991.1  keratin, type II cytoskeletal 3 isoform X1