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    OGN osteoglycin [ Homo sapiens (human) ]

    Gene ID: 4969, updated on 9-Dec-2024

    Summary

    Official Symbol
    OGNprovided by HGNC
    Official Full Name
    osteoglycinprovided by HGNC
    Primary source
    HGNC:HGNC:8126
    See related
    Ensembl:ENSG00000106809 MIM:602383; AllianceGenome:HGNC:8126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OG; OIF; SLRR3A
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See OGN in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (92383268..92404699, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (104549769..104571196, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95145550..95166981, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:95086914-95087802 Neighboring gene nucleolar protein 8 Neighboring gene phagophore assembly factor 1 pseudogene Neighboring gene centromere protein P Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109628 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109638 Neighboring gene osteomodulin Neighboring gene asporin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp586P2421

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    mimecan
    Names
    corneal keratan sulfate proteoglycan
    mimecan proteoglycan
    osteoinductive factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014057.5NP_054776.1  mimecan isoform 2 precursor

      See identical proteins and their annotated locations for NP_054776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (2).
      Source sequence(s)
      AF086912, AF100758, AK295433, AL137848, BM679549
      Consensus CDS
      CCDS6695.1
      UniProtKB/Swiss-Prot
      P20774, Q6FIB0, Q9UF90, Q9UNK5
      UniProtKB/TrEMBL
      A8K0R3, Q7Z532
      Related
      ENSP00000364711.5, ENST00000375561.10
      Conserved Domains (2) summary
      sd00033
      Location:123144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143225
      LRR_8; Leucine rich repeat
    2. NM_024416.4NP_077727.3  mimecan isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (1) has a longer N-terminus and lacks a predicted signal peptide compared to isoform 2.
      Source sequence(s)
      AF086912, AK295433, AL137848, BC095443, BG772245, BM679549
      UniProtKB/TrEMBL
      B4DI63, Q7Z532
      Conserved Domains (3) summary
      sd00033
      Location:181202
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:181218
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:201283
      LRR_8; Leucine rich repeat
    3. NM_033014.4NP_148935.1  mimecan isoform 2 precursor

      See identical proteins and their annotated locations for NP_148935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (2). Both variants 1 and 3 encode the same isoform (2).
      Source sequence(s)
      AL137848, BC095443, BG772245, BM679549, CB268982
      Consensus CDS
      CCDS6695.1
      UniProtKB/Swiss-Prot
      P20774, Q6FIB0, Q9UF90, Q9UNK5
      UniProtKB/TrEMBL
      A8K0R3, Q7Z532
      Related
      ENSP00000262551.4, ENST00000262551.8
      Conserved Domains (2) summary
      sd00033
      Location:123144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143225
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      92383268..92404699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791788.1 Reference GRCh38.p14 PATCHES

      Range
      217997..239428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      104549769..104571196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)