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    KLF2 KLF transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 10365, updated on 9-Dec-2024

    Summary

    Official Symbol
    KLF2provided by HGNC
    Official Full Name
    KLF transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:6347
    See related
    Ensembl:ENSG00000127528 MIM:602016; AllianceGenome:HGNC:6347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LKLF
    Summary
    This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in fat (RPKM 40.2), ovary (RPKM 23.1) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KLF2 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16324826..16328685)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16459702..16463562)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16435637..16439496)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10292 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:16315239-16315388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16334661-16335161 Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16362883-16363384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16363385-16363884 Neighboring gene KLF2-I enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14219 Neighboring gene MPRA-validated peak3390 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10293 Neighboring gene KLF2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14221 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16435432-16436204 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16436205-16436975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14227 Neighboring gene epidermal growth factor receptor pathway substrate 15 like 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16486555-16487056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16494079-16494580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16528701-16529304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16531117-16531720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16531721-16532324 Neighboring gene ribosomal protein S2 pseudogene 51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16551872-16552372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16552373-16552873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14232 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:16555578-16556777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16564379-16564879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16565415-16565914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16567358-16568116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16572441-16573108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16573109-16573776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16575487-16576411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16581959-16582870 Neighboring gene Sharpr-MPRA regulatory region 3003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16606242-16606742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16606743-16607243 Neighboring gene calreticulin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of Kruppel-like factor 2 (KLF2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of Kruppel-like factor 2 (KLF2) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cycloheximide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to laminar fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular stress response to acid chemical IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epigenetic regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type I pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 2
    Names
    Kruppel like factor 2
    Kruppel-like factor 2 (lung)
    Kruppel-like factor LKLF
    lung Kruppel-like factor
    lung Kruppel-like zinc finger transcription factor
    lung krueppel-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016270.4NP_057354.1  Krueppel-like factor 2

      See identical proteins and their annotated locations for NP_057354.1

      Status: REVIEWED

      Source sequence(s)
      AC020917
      Consensus CDS
      CCDS12343.1
      UniProtKB/Swiss-Prot
      Q6IPC4, Q9UJS5, Q9UKR6, Q9Y5W3
      Related
      ENSP00000248071.5, ENST00000248071.6
      Conserved Domains (4) summary
      COG5048
      Location:267350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:272296
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:318343
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      16324826..16328685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      16459702..16463562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_006075.1: Suppressed sequence

      Description
      NM_006075.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    2. NM_016198.1: Suppressed sequence

      Description
      NM_016198.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.