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    ADPGK ADP dependent glucokinase [ Homo sapiens (human) ]

    Gene ID: 83440, updated on 3-Dec-2024

    Summary

    Official Symbol
    ADPGKprovided by HGNC
    Official Full Name
    ADP dependent glucokinaseprovided by HGNC
    Primary source
    HGNC:HGNC:25250
    See related
    Ensembl:ENSG00000159322 MIM:611861; AllianceGenome:HGNC:25250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADP-GK; 2610017G09Rik
    Summary
    ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 23.6), appendix (RPKM 19.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADPGK in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72751294..72783758, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70568596..70601068, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73043635..73076099, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 2B Neighboring gene MPRA-validated peak2381 silencer Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9730 Neighboring gene ADPGK antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73099527-73100423 Neighboring gene NANOG hESC enhancer GRCh37_chr15:73113063-73113588 Neighboring gene uncharacterized LOC107984801 Neighboring gene NANOG hESC enhancer GRCh37_chr15:73127371-73127872 Neighboring gene nucleophosmin 1 pseudogene 42

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434B195

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP-specific glucokinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ADP-specific glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ADP-specific glucokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process through glucose-6-phosphate TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    ADP-dependent glucokinase
    Names
    ATP-dependent glucokinase
    rbBP-35
    NP_001352152.1
    NP_001352153.1
    NP_001352154.1
    NP_001352155.1
    NP_001352156.1
    NP_001352157.1
    NP_001352158.1
    NP_112574.3
    XP_011520406.1
    XP_016878153.1
    XP_047289120.1
    XP_054234954.1
    XP_054234955.1
    XP_054234956.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365223.1NP_001352152.1  ADP-dependent glucokinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009712, AK075560, BC044589, DA031990, DA208247
      UniProtKB/TrEMBL
      B4DDP8
      Conserved Domains (1) summary
      cd01938
      Location:1369
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
    2. NM_001365224.1NP_001352153.1  ADP-dependent glucokinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009712, AK055526, AK075560
      UniProtKB/TrEMBL
      Q69YR1
      Conserved Domains (1) summary
      cl00192
      Location:1253
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    3. NM_001365225.1NP_001352154.1  ADP-dependent glucokinase isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009712, BC006112, DA031990
      Consensus CDS
      CCDS92041.1
      UniProtKB/Swiss-Prot
      Q49AU7, Q8NBI1, Q8WZ90, Q96NF8, Q9BRR6, Q9H0A7
      UniProtKB/TrEMBL
      B4DG35
      Related
      ENSP00000397694.3, ENST00000456471.3
      Conserved Domains (1) summary
      cd01938
      Location:60492
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
    4. NM_001365226.1NP_001352155.1  ADP-dependent glucokinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC009712
      UniProtKB/TrEMBL
      B4DDP8
      Conserved Domains (1) summary
      cd01938
      Location:1370
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
    5. NM_001365227.1NP_001352156.1  ADP-dependent glucokinase isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009712, BI906568
      Conserved Domains (1) summary
      cl00192
      Location:60353
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    6. NM_001365228.1NP_001352157.1  ADP-dependent glucokinase isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009712, DA600729
      Conserved Domains (1) summary
      cl00192
      Location:60352
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    7. NM_001365229.1NP_001352158.1  ADP-dependent glucokinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009712
      UniProtKB/TrEMBL
      Q69YR1
      Conserved Domains (1) summary
      cl00192
      Location:1253
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    8. NM_031284.5NP_112574.3  ADP-dependent glucokinase isoform 1 precursor

      See identical proteins and their annotated locations for NP_112574.3

      Status: VALIDATED

      Source sequence(s)
      AC009712, AK075560, DA031990, DB279245
      Consensus CDS
      CCDS42057.1
      UniProtKB/TrEMBL
      B4DG35
      Related
      ENSP00000312250.8, ENST00000311669.12
      Conserved Domains (1) summary
      cd01938
      Location:60491
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72751294..72783758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522104.4XP_011520406.1  ADP-dependent glucokinase isoform X2

      Conserved Domains (1) summary
      cl00192
      Location:60313
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    2. XM_047433164.1XP_047289120.1  ADP-dependent glucokinase isoform X1

      UniProtKB/TrEMBL
      B4DDP8
    3. XM_017022664.3XP_016878153.1  ADP-dependent glucokinase isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      70568596..70601068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378980.1XP_054234955.1  ADP-dependent glucokinase isoform X2

    2. XM_054378979.1XP_054234954.1  ADP-dependent glucokinase isoform X1

      UniProtKB/TrEMBL
      B4DDP8
    3. XM_054378981.1XP_054234956.1  ADP-dependent glucokinase isoform X3