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    TAS2R1 taste 2 receptor member 1 [ Homo sapiens (human) ]

    Gene ID: 50834, updated on 9-Dec-2024

    Summary

    Official Symbol
    TAS2R1provided by HGNC
    Official Full Name
    taste 2 receptor member 1provided by HGNC
    Primary source
    HGNC:HGNC:14909
    See related
    Ensembl:ENSG00000169777 MIM:604796; AllianceGenome:HGNC:14909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R1; TRB7
    Summary
    This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See TAS2R1 in Genome Data Viewer
    Location:
    5p15.31-p15.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (9627347..9903876, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (9567134..9843682, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (9627459..9903988, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 123 Neighboring gene small nucleolar RNA host gene 18 Neighboring gene uncharacterized LOC101929359 Neighboring gene uncharacterized LOC124900938 Neighboring gene long intergenic non-protein coding RNA 2112 Neighboring gene uncharacterized LOC105374649 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9774748-9775340 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:9775483-9776682 Neighboring gene RNA, 5S ribosomal pseudogene 177 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9832529-9833029 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9832028-9832528 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9833753-9834254 Neighboring gene long intergenic non-protein coding RNA 2221 Neighboring gene NANOG hESC enhancer GRCh37_chr5:9895310-9895811 Neighboring gene uncharacterized LOC107986405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:9944391-9944892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:9944893-9945392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15911 Neighboring gene uncharacterized LOC124900939

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide linkage and association scan reveals novel loci for autism.
    EBI GWAS Catalog
    Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
    EBI GWAS Catalog

    Pathways from PubChem

    General protein information

    Preferred Names
    taste receptor type 2 member 1
    Names
    taste receptor, family B, member 7
    taste receptor, type 2, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386348.1NP_001373277.1  taste receptor type 2 member 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC026787, AC034214, AC091958
      UniProtKB/TrEMBL
      Q50L07
      Conserved Domains (1) summary
      cd15016
      Location:1249
      7tm_TAS2R1; mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily
    2. NM_019599.3NP_062545.1  taste receptor type 2 member 1 isoform 1

      See identical proteins and their annotated locations for NP_062545.1

      Status: REVIEWED

      Source sequence(s)
      AC034214
      Consensus CDS
      CCDS3876.1
      UniProtKB/Swiss-Prot
      Q646G8, Q9NYW7
      UniProtKB/TrEMBL
      Q502V6
      Related
      ENSP00000371932.2, ENST00000382492.4
      Conserved Domains (1) summary
      pfam05296
      Location:1296
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      9627347..9903876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      9567134..9843682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)