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    SELENOS selenoprotein S [ Homo sapiens (human) ]

    Gene ID: 55829, updated on 9-Dec-2024

    Summary

    Official Symbol
    SELENOSprovided by HGNC
    Official Full Name
    selenoprotein Sprovided by HGNC
    Primary source
    HGNC:HGNC:30396
    See related
    Ensembl:ENSG00000131871 MIM:607918; AllianceGenome:HGNC:30396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015
    Summary
    This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in testis (RPKM 27.4), colon (RPKM 26.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SELENOS in Genome Data Viewer
    Location:
    15q26.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101270809..101277485, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99025841..99032517, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101811014..101817690, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101719289-101719899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101719900-101720509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101729693-101730580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101733708-101734251 Neighboring gene Sharpr-MPRA regulatory region 9624 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:101745934-101746099 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6887 Neighboring gene uncharacterized LOC107984727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10191 Neighboring gene Sharpr-MPRA regulatory region 1457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101807276-101807810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101834407-101835038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10194 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene SNRPA1 divergent transcript Neighboring gene proprotein convertase subtilisin/kexin type 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2553, MGC104346

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ER overload response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ER overload response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of protein localization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of D-glucose import TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glycogen biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of gluconeogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of nitric oxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to redox state IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde protein transport, ER to cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Derlin-1-VIMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Derlin-1-VIMP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    part_of low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of very-low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    selenoprotein S
    Names
    VCP interacting membrane selenoprotein
    VCP-interacting membrane protein
    tanis
    valosin-containing protein-interacting membrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013322.1 RefSeqGene

      Range
      5011..10305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018445.6NP_060915.2  selenoprotein S isoform 1

      See identical proteins and their annotated locations for NP_060915.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1).
      Source sequence(s)
      AK097011, BC005840, BG829960
      Consensus CDS
      CCDS53979.1
      UniProtKB/Swiss-Prot
      Q3B771, Q9BQE4, Q9P0I6
      UniProtKB/TrEMBL
      A0A182DWI4
      Related
      ENSP00000433541.1, ENST00000526049.6
      Conserved Domains (1) summary
      pfam06936
      Location:1187
      Selenoprotein_S; Selenoprotein S (SelS)
    2. NM_203472.3NP_982298.2  selenoprotein S isoform 2

      See identical proteins and their annotated locations for NP_982298.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and lacks a selenocysteine (Sec) insertion sequence (SECIS) element in its 3' UTR, which is necessary for the recognition of UGA as a Sec codon. This results in translation termination at the UGA codon and a non-Sec containing shorter isoform (2) compared to isoform 1 (PMID:23614019).
      Source sequence(s)
      AC023024, BC107774, BG829960, DW430970
      UniProtKB/TrEMBL
      A0A182DWI4, Q6GYA4
      Related
      ENSP00000381282.3, ENST00000398226.8
      Conserved Domains (1) summary
      pfam06936
      Location:1187
      Selenoprotein_S; Selenoprotein S (SelS)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      101270809..101277485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      99025841..99032517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)