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    RAD23B RAD23 homolog B, nucleotide excision repair protein [ Homo sapiens (human) ]

    Gene ID: 5887, updated on 9-Dec-2024

    Summary

    Official Symbol
    RAD23Bprovided by HGNC
    Official Full Name
    RAD23 homolog B, nucleotide excision repair proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9813
    See related
    Ensembl:ENSG00000119318 MIM:600062; AllianceGenome:HGNC:9813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P58; HR23B; HHR23B
    Summary
    The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in liver (RPKM 44.7), fat (RPKM 43.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAD23B in Genome Data Viewer
    Location:
    9q31.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (107283279..107332194)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (119455054..119503938)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (110045560..110094475)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene importin subunit alpha-1-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28749 Neighboring gene uncharacterized LOC107987110 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:110005805-110007004 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:110011081-110012047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:110020689-110021228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20156 Neighboring gene uncharacterized LOC124902241 Neighboring gene Sharpr-MPRA regulatory region 15312 Neighboring gene uncharacterized LOC107987111

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
    EBI GWAS Catalog
    Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
    EBI GWAS Catalog
    Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies RAD23 homolog B (RAD23B) is important for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA damage sensor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of XPC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UV excision repair protein RAD23 homolog B
    Names
    RAD23, yeast homolog of, B
    XP-C repair complementing complex 58 kDa
    XP-C repair complementing protein
    XP-C repair-complementing complex 58 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244713.1NP_001231642.1  UV excision repair protein RAD23 homolog B isoform 2

      See identical proteins and their annotated locations for NP_001231642.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and 5' CDS, compared to isoform (1), which results in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AI375313, AK297986, AL137852, BI460482
      UniProtKB/TrEMBL
      B7Z4W4, B7ZA74
      Conserved Domains (1) summary
      TIGR00601
      Location:2386
      rad23; UV excision repair protein Rad23
    2. NM_001244724.2NP_001231653.1  UV excision repair protein RAD23 homolog B isoform 3

      See identical proteins and their annotated locations for NP_001231653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to isoform (1). The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK297986, AL137852, AY313777
      Consensus CDS
      CCDS59138.1
      UniProtKB/TrEMBL
      B7ZA74
      Related
      ENSP00000405623.2, ENST00000416373.6
      Conserved Domains (1) summary
      TIGR00601
      Location:1335
      rad23; UV excision repair protein Rad23
    3. NM_002874.5NP_002865.1  UV excision repair protein RAD23 homolog B isoform 1

      See identical proteins and their annotated locations for NP_002865.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL137852, D21090, DC404422
      Consensus CDS
      CCDS6769.1
      UniProtKB/Swiss-Prot
      B3KWK8, G5E9P0, P54727, Q7Z5K8, Q8WUB0
      UniProtKB/TrEMBL
      Q53F10
      Related
      ENSP00000350708.3, ENST00000358015.8
      Conserved Domains (1) summary
      TIGR00601
      Location:1407
      rad23; UV excision repair protein Rad23

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      107283279..107332194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      119455054..119503938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)