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    DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 [ Homo sapiens (human) ]

    Gene ID: 5611, updated on 3-Dec-2024

    Summary

    Official Symbol
    DNAJC3provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C3provided by HGNC
    Primary source
    HGNC:HGNC:9439
    See related
    Ensembl:ENSG00000102580 MIM:601184; AllianceGenome:HGNC:9439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK; p58(IPK)
    Summary
    This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 25.8), prostate (RPKM 15.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DNAJC3 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (95677139..95794988)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (94881700..94999557)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96329393..96447242)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903194 Neighboring gene H3K27ac hESC enhancers GRCh37_chr13:96328483-96329330 and GRCh37_chr13:96329331-96330177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7883 Neighboring gene DNAJC3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5448 Neighboring gene Sharpr-MPRA regulatory region 4273 Neighboring gene MT-ND6 pseudogene 18 Neighboring gene MT-ND5 pseudogene 2 Neighboring gene MT-CYB pseudogene 3 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96558977-96559478 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96606253-96607155 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611347-96611848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611849-96612348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96666836-96667336 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:96693792-96694381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96705417-96705916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96741684-96742184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96742185-96742685 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with DNAJC3; predicted interaction to be involved in antigenicity/immunity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21288

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular vesicle HDA PubMed 
    located_in membrane HDA PubMed 
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 3
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 3
    ER-resident protein ERdj6
    endoplasmic reticulum DNA J domain-containing protein 6
    interferon-induced, double-stranded RNA-activated protein kinase inhibitor
    protein kinase inhibitor of 58 kDa
    protein kinase inhibitor p58
    protein-kinase, interferon-inducible double stranded RNA dependent inhibitor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041830.1 RefSeqGene

      Range
      5001..122850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006260.5NP_006251.1  dnaJ homolog subfamily C member 3 precursor

      See identical proteins and their annotated locations for NP_006251.1

      Status: REVIEWED

      Source sequence(s)
      AA430108, AK292947, AL136104, AL138955, BC047936
      Consensus CDS
      CCDS9479.1
      UniProtKB/Swiss-Prot
      Q13217, Q86WT9, Q8N4N2
      UniProtKB/TrEMBL
      A8KA82, X6R9L0
      Related
      ENSP00000473631.1, ENST00000602402.6
      Conserved Domains (3) summary
      COG0484
      Location:392498
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:3765
      TPR; TPR repeat [structural motif]
      cl26002
      Location:31394
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      95677139..95794988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521104.3XP_011519406.1  dnaJ homolog subfamily C member 3 isoform X1

      UniProtKB/TrEMBL
      X6R9L0
      Conserved Domains (6) summary
      COG0484
      Location:421527
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:3765
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:423488
      DnaJ; DnaJ domain
      pfam00515
      Location:369402
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:36100
      TPR_11; TPR repeat
      pfam14559
      Location:347411
      TPR_19; Tetratricopeptide repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      94881700..94999557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374756.1XP_054230731.1  dnaJ homolog subfamily C member 3 isoform X1

      UniProtKB/TrEMBL
      X6R9L0