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    GLMP glycosylated lysosomal membrane protein [ Homo sapiens (human) ]

    Gene ID: 112770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GLMPprovided by HGNC
    Official Full Name
    glycosylated lysosomal membrane proteinprovided by HGNC
    Primary source
    HGNC:HGNC:29436
    See related
    Ensembl:ENSG00000198715 MIM:619958; AllianceGenome:HGNC:29436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCU-G1; C1orf85; lnc-UCID
    Summary
    Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; lysosome; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 30.2), placenta (RPKM 24.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GLMP in Genome Data Viewer
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156292688..156295679, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155431151..155434142, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156262479..156265470, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PMF1-BGLAP readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1424 Neighboring gene Sharpr-MPRA regulatory region 3040 Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156250697-156251670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156252643-156253614 Neighboring gene Sharpr-MPRA regulatory regions 9834 and 13552 Neighboring gene transmembrane protein 79 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156271210-156271710 Neighboring gene MPRA-validated peak424 silencer Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156297025-156297871 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156297872-156298717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene TSSK6 activating cochaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway. Liu Y, et al. Cell Death Dis, 2023 Nov 1. PMID 37914704, Free PMC Article
    2. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. Steffensen KR, et al. BMC Mol Biol, 2007 Nov 16. PMID 18021396, Free PMC Article
    3. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. Schieweck O, et al. Biochem J, 2009 Jul 29. PMID 19489740
    4. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. Massa López D, et al. Elife, 2019 Oct 29. PMID 31661432, Free PMC Article
    5. A gene network regulating lysosomal biogenesis and function. Sardiello M, et al. Science, 2009 Jul 24. PMID 19556463

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway.
      Title: N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway.
    2. NCU-G1 is a dual-function protein capable of functioning as a transcription factor as well as a nuclear receptor co-activator.
      Title: Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31963

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycosylated lysosomal membrane protein
    Names
    kidney lysosomal membrane protein
    kidney predominant protein NCU-G1
    lncRNA up-regulating CDK6 by interacting with DHX9
    lysosomal protein NCU-G1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256604.2 → NP_001243533.1  glycosylated lysosomal membrane protein isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BP302818, CA428514, CX756681, DA537642
      Conserved Domains (1) summary
      pfam15065
      Location:55 → 328
      NCU-G1; Lysosomal transcription factor, NCU-G1

    2. NM_001256605.2 → NP_001243534.1  glycosylated lysosomal membrane protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_001243534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL528533, BM833126, CA428514, DA537642
      Consensus CDS
      CCDS72948.1
      UniProtKB/TrEMBL
      A0A087WV34
      Related
      ENSP00000479149.1, ENST00000622703.4
      Conserved Domains (1) summary
      pfam15065
      Location:40 → 291
      NCU-G1; Lysosomal transcription factor, NCU-G1

    3. NM_001256608.2 → NP_001243537.1  glycosylated lysosomal membrane protein isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AW293248, CN479212, CX756681, DA537642, N72839
      Consensus CDS
      CCDS72949.1
      UniProtKB/TrEMBL
      A0A087X0W3
      Related
      ENSP00000483691.1, ENST00000612353.4
      Conserved Domains (1) summary
      pfam15065
      Location:55 → 267
      NCU-G1; Lysosomal transcription factor, NCU-G1

    4. NM_001256609.2 → NP_001243538.1  glycosylated lysosomal membrane protein isoform 5

      See identical proteins and their annotated locations for NP_001243538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK296157, CA428514, DA537642
      Consensus CDS
      CCDS72947.1
      UniProtKB/Swiss-Prot
      Q8WWB7
      Related
      ENSP00000480936.1, ENST00000614643.4
      Conserved Domains (1) summary
      pfam15065
      Location:1 → 296
      NCU-G1; Lysosomal transcription factor, NCU-G1

    5. NM_144580.3 → NP_653181.1  glycosylated lysosomal membrane protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_653181.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC018757, DA537642, N72839
      Consensus CDS
      CCDS1139.1
      UniProtKB/Swiss-Prot
      A6NH16, B4DJN4, Q5SZX4, Q6UX96, Q8IV07, Q8WWB7, Q96F65
      Related
      ENSP00000354553.1, ENST00000362007.6
      Conserved Domains (1) summary
      pfam15065
      Location:55 → 377
      NCU-G1; Lysosomal transcription factor, NCU-G1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156292688..156295679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442998.1 → XP_047298954.1  glycosylated lysosomal membrane protein isoform X1

    2. XM_011509117.4 → XP_011507419.1  glycosylated lysosomal membrane protein isoform X2

      Conserved Domains (1) summary
      pfam15065
      Location:2 → 200
      NCU-G1; Lysosomal transcription factor, NCU-G1

    RNA

    1. XR_426762.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155431151..155434142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334008.1 → XP_054189983.1  glycosylated lysosomal membrane protein isoform X1

    2. XM_054334009.1 → XP_054189984.1  glycosylated lysosomal membrane protein isoform X2

    RNA

    1. XR_008485882.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWB7.1 GenPept UniProtKB/Swiss-Prot:Q8WWB7

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