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    TSTD1 thiosulfate sulfurtransferase like domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 100131187, updated on 27-Nov-2024

    Summary

    Official Symbol
    TSTD1provided by HGNC
    Official Full Name
    thiosulfate sulfurtransferase like domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:35410
    See related
    Ensembl:ENSG00000215845 MIM:616041; AllianceGenome:HGNC:35410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT; TST
    Summary
    Predicted to enable thiosulfate-thiol sulfurtransferase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Located in cytoplasmic ribonucleoprotein granule and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 33.0), kidney (RPKM 26.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TSTD1 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161037631..161038964, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160175138..160176471, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161007421..161008754, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F11 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160975781-160976290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976291-160976800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976801-160977309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160985695-160986292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:160991075-160991672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161002153-161003089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161004943-161005449 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161005450-161005955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1970 Neighboring gene GLR5 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1972 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:161015335-161016534 Neighboring gene upstream transcription factor 1 Neighboring gene Rho GTPase activating protein 30 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161038974-161039520

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General protein information

    Preferred Names
    thiosulfate:glutathione sulfurtransferase
    Names
    putative thiosulfate sulfurtransferase KAT
    thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
    thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
    NP_001106676.1
    NP_001106677.1
    NP_001106678.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113205.2NP_001106676.1  thiosulfate:glutathione sulfurtransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that results in a frameshift and premature stop codon, compared to variant 1. The encoded protein (isoform 3) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AV688621, BC001699
      Consensus CDS
      CCDS44258.1
      UniProtKB/Swiss-Prot
      Q8NFU3
      Related
      ENSP00000325518.10, ENST00000318289.14
      Conserved Domains (1) summary
      cl00125
      Location:7101
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    2. NM_001113206.2NP_001106677.1  thiosulfate:glutathione sulfurtransferase isoform 2

      See identical proteins and their annotated locations for NP_001106677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, that results a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AV688621, CD675389
      Consensus CDS
      CCDS44257.1
      UniProtKB/TrEMBL
      R4GNF9
      Related
      ENSP00000357003.1, ENST00000368024.5
      Conserved Domains (1) summary
      cl00125
      Location:471
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    3. NM_001113207.2NP_001106678.1  thiosulfate:glutathione sulfurtransferase isoform 1

      See identical proteins and their annotated locations for NP_001106678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      CD675389
      Consensus CDS
      CCDS53400.1
      UniProtKB/Swiss-Prot
      Q5SY48, Q5SY49, Q5SY50, Q5SY51, Q8NFU2, Q8NFU3, Q9BV22
      Related
      ENSP00000388293.2, ENST00000423014.3
      Conserved Domains (1) summary
      cl00125
      Location:7112
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161037631..161038964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160175138..160176471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)