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    UBE2R2 ubiquitin conjugating enzyme E2 R2 [ Homo sapiens (human) ]

    Gene ID: 54926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UBE2R2provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 R2provided by HGNC
    Primary source
    HGNC:HGNC:19907
    See related
    Ensembl:ENSG00000107341 MIM:612506; AllianceGenome:HGNC:19907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC3B; CDC34B; E2-CDC34B
    Summary
    Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 25.6), endometrium (RPKM 16.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBE2R2 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33815168..33920399)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33835748..33938999)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33817158..33920397)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33721507-33722008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33722009-33722508 Neighboring gene UBE2R2 antisense RNA 1 Neighboring gene MPRA-validated peak7221 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28301 Neighboring gene serine protease 3 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33796108-33796608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19839 Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33927431-33928421 Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene ubiquitin associated protein 2 Neighboring gene small nucleolar RNA, C/D box 121A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SMYD3 promotes epithelial ovarian cancer metastasis by downregulating p53 protein stability and promoting p53 ubiquitination. Zhang L, et al. Carcinogenesis, 2019 Dec 31. PMID 31002112
    2. An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver. Fernández-Ginés R, et al. Redox Biol, 2022 Sep. PMID 35839629, Free PMC Article
    3. Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme. Hill S, et al. Mol Cell Biol, 2016 Jun 1. PMID 27044868, Free PMC Article
    4. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Pierce NW, et al. Cell, 2013 Mar 28. PMID 23453757, Free PMC Article
    5. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. Semplici F, et al. Oncogene, 2002 Jun 6. PMID 12037680

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
      Title: Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
    2. UBE2R2 alone had negligible ubiquitylation activity at physiological concentrations and the ablation of UBE2R1/2 had no effect on the stability of SCF substrates in cells. A genome-wide CRISPR screen revealed that an additional E2 enzyme, UBE2G1, buffers against the loss of UBE2R1/2.
      Title: Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.
    3. Study shows that Ube2R1/2 forms a salt bridge interaction between a conserved Asp residue on Ube2R1/2 and acceptor ubiquitin residue Arg 54 and that perturbation of this interaction leads to the severe loss of UbeR2 activity. Results also provide new insight into how the Ube2R1/2 acidic loop may participate in catalysis.
      Title: Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    6. Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B]
      Title: CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20419, MGC10481

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 R2
    Names
    E2 ubiquitin-conjugating enzyme R2
    ubiquitin carrier protein R2
    ubiquitin conjugating enzyme E2R 2
    ubiquitin-conjugating enzyme E2-CDC34B
    ubiquitin-conjugating enzyme UBC3B
    ubiquitin-protein ligase R2
    NP_060281.2
    XP_005251553.1
    XP_011516251.1
    XP_016870349.1
    XP_047279497.1
    XP_054219154.1
    XP_054219155.1
    XP_054219156.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017811.4 → NP_060281.2  ubiquitin-conjugating enzyme E2 R2

      See identical proteins and their annotated locations for NP_060281.2

      Status: REVIEWED

      Source sequence(s)
      AA397839, AK000426, AL133827, AL139113, AW966809, BC004862, BC047584, BI061548, BI908167, BQ432410, CD515389, CN310827, CN427315
      Consensus CDS
      CCDS6546.1
      UniProtKB/Swiss-Prot
      D3DRL5, Q712K3, Q9NX64
      Related
      ENSP00000263228.3, ENST00000263228.4
      Conserved Domains (1) summary
      cd00195
      Location:11 → 169
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33815168..33920399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423541.1 → XP_047279497.1  ubiquitin-conjugating enzyme E2 R2 isoform X4

    2. XM_011517949.2 → XP_011516251.1  ubiquitin-conjugating enzyme E2 R2 isoform X2

      See identical proteins and their annotated locations for XP_011516251.1

      Conserved Domains (1) summary
      cd00195
      Location:11 → 122
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. XM_005251496.3 → XP_005251553.1  ubiquitin-conjugating enzyme E2 R2 isoform X1

      See identical proteins and their annotated locations for XP_005251553.1

      Conserved Domains (1) summary
      cd00195
      Location:11 → 140
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. XM_017014860.2 → XP_016870349.1  ubiquitin-conjugating enzyme E2 R2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33835748..33938999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363180.1 → XP_054219155.1  ubiquitin-conjugating enzyme E2 R2 isoform X2

    2. XM_054363179.1 → XP_054219154.1  ubiquitin-conjugating enzyme E2 R2 isoform X1

    3. XM_054363181.1 → XP_054219156.1  ubiquitin-conjugating enzyme E2 R2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q712K3.1 GenPept UniProtKB/Swiss-Prot:Q712K3

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