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    ZCRB1 zinc finger CCHC-type and RNA binding motif containing 1 [ Homo sapiens (human) ]

    Gene ID: 85437, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZCRB1provided by HGNC
    Official Full Name
    zinc finger CCHC-type and RNA binding motif containing 1provided by HGNC
    Primary source
    HGNC:HGNC:29620
    See related
    Ensembl:ENSG00000139168 MIM:610750; AllianceGenome:HGNC:29620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19
    Summary
    Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 32.6), brain (RPKM 19.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZCRB1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (42312086..42326094, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (42270020..42284029, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (42705888..42719896, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 2 mRNA binding protein 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6210 Neighboring gene uncharacterized LOC124902921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6211 Neighboring gene microRNA 7851 Neighboring gene periphilin 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:42742996-42743992 Neighboring gene RNA, U6 small nuclear 249, pseudogene Neighboring gene FMR1 autosomal homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Binding of the 5'-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA-binding motif 1 enhances viral replication and transcription. Tan YW, et al. Nucleic Acids Res, 2012 Jun. PMID 22362731, Free PMC Article
    2. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Wang H, et al. Genomics, 2007 Jan. PMID 16959469
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. Will CL, et al. RNA, 2004 Jun. PMID 15146077, Free PMC Article
    4. Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase. Lenihan JA, et al. PLoS One, 2017. PMID 29121065, Free PMC Article
    5. Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus. Zheng X, et al. Pathogens, 2021 Sep 8. PMID 34578187, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26805

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC-type and RNA-binding motif-containing protein 1
    Names
    U11/U12 small nuclear ribonucleoprotein 31 kDa protein
    U11/U12 snRNP 31 kDa protein
    U11/U12 snRNP 31K
    U11/U12-31K
    zinc finger CCHC-type and RNA binding motif 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033114.4 → NP_149105.3  zinc finger CCHC-type and RNA-binding motif-containing protein 1

      See identical proteins and their annotated locations for NP_149105.3

      Status: REVIEWED

      Source sequence(s)
      AB062361, BC022543, BI666919
      Consensus CDS
      CCDS8740.1
      UniProtKB/Swiss-Prot
      Q6PJX0, Q8TBF4, Q96TA6
      UniProtKB/TrEMBL
      F8VXY6
      Related
      ENSP00000266529.3, ENST00000266529.8
      Conserved Domains (2) summary
      cd12393
      Location:9 → 86
      RRM_ZCRB1; RNA recognition motif in Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) and similar proteins
      cl26705
      Location:97 → 123
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      42312086..42326094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020124.2 → XP_016875613.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      G3V1V1
      Related
      ENSP00000504144.1, ENST00000676501.1
      Conserved Domains (2) summary
      PTZ00368
      Location:56 → 82
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cl17169
      Location:1 → 43
      RRM_SF; RNA recognition motif (RRM) superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      42270020..42284029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373691.1 → XP_054229666.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      G3V1V1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBF4.2 GenPept UniProtKB/Swiss-Prot:Q8TBF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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