U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PTOV1 PTOV1 extended AT-hook containing adaptor protein [ Homo sapiens (human) ]

    Gene ID: 53635, updated on 9-Dec-2024

    Summary

    Official Symbol
    PTOV1provided by HGNC
    Official Full Name
    PTOV1 extended AT-hook containing adaptor proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9632
    See related
    Ensembl:ENSG00000104960 MIM:610195; AllianceGenome:HGNC:9632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACID2; PTOV-1
    Summary
    This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in testis (RPKM 29.1), adrenal (RPKM 28.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTOV1 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49850705..49860742)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52850843..52860879)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50353962..50363999)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10936 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50316420-50317226 Neighboring gene fuzzy planar cell polarity protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14958 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50321502-50321668 Neighboring gene mediator complex subunit 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50337816-50338316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50338317-50338817 Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14963 Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50368723-50369505 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50369506-50370288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50370289-50371070 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50373269-50373916 Neighboring gene polynucleotide kinase 3'-phosphatase Neighboring gene AKT1 substrate 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50379233-50380192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50381153-50382112 Neighboring gene TBC1 domain family member 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71475, DKFZp586I111

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    prostate tumor-overexpressed gene 1 protein
    Names
    activator interaction domain-containing protein 2
    prostate tumor overexpressed 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050666.1 RefSeqGene

      Range
      6892..16901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001305105.2NP_001292034.1  prostate tumor-overexpressed gene 1 protein isoform 1

      See identical proteins and their annotated locations for NP_001292034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.
      Source sequence(s)
      AA582677, AC018766, AJ617480
      Consensus CDS
      CCDS12782.1
      UniProtKB/Swiss-Prot
      Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1
      Related
      ENSP00000469128.1, ENST00000599732.5
      Conserved Domains (1) summary
      pfam11232
      Location:93238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    2. NM_001305108.2NP_001292037.1  prostate tumor-overexpressed gene 1 protein isoform 2

      See identical proteins and their annotated locations for NP_001292037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' region, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AC018766
      Consensus CDS
      CCDS82379.1
      UniProtKB/TrEMBL
      A0A0C4DGR2
      Related
      ENSP00000471458.1, ENST00000600603.5
      Conserved Domains (1) summary
      pfam11232
      Location:61206
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    3. NM_001364745.2NP_001351674.1  prostate tumor-overexpressed gene 1 protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Consensus CDS
      CCDS92668.1
      UniProtKB/TrEMBL
      M0QY25
      Related
      ENSP00000469541.1, ENST00000601638.5
      Conserved Domains (1) summary
      pfam11232
      Location:61206
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    4. NM_001364747.2NP_001351676.1  prostate tumor-overexpressed gene 1 protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Conserved Domains (2) summary
      pfam11232
      Location:108253
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      cl26247
      Location:1156
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    5. NM_001364748.2NP_001351677.1  prostate tumor-overexpressed gene 1 protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Conserved Domains (1) summary
      pfam11232
      Location:117258
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    6. NM_001364749.2NP_001351678.1  prostate tumor-overexpressed gene 1 protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Conserved Domains (2) summary
      pfam11232
      Location:108253
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      cl26247
      Location:1156
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    7. NM_001364750.2NP_001351679.1  prostate tumor-overexpressed gene 1 protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Related
      ENST00000598325.5
      Conserved Domains (1) summary
      pfam11232
      Location:117258
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    8. NM_001394010.1NP_001380939.1  prostate tumor-overexpressed gene 1 protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Consensus CDS
      CCDS12782.1
      UniProtKB/Swiss-Prot
      Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1
      Related
      ENSP00000375717.1, ENST00000391842.6
      Conserved Domains (1) summary
      pfam11232
      Location:93238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    9. NM_017432.5NP_059128.2  prostate tumor-overexpressed gene 1 protein isoform 1

      See identical proteins and their annotated locations for NP_059128.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.
      Source sequence(s)
      AA582677, AC018766, BC042921
      Consensus CDS
      CCDS12782.1
      UniProtKB/Swiss-Prot
      Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1
      Related
      ENSP00000472816.1, ENST00000601675.5
      Conserved Domains (1) summary
      pfam11232
      Location:93238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    RNA

    1. NR_130963.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in two exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018766
      Related
      ENST00000601612.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49850705..49860742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438940.1XP_047294896.1  prostate tumor-overexpressed gene 1 protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52850843..52860879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321224.1XP_054177199.1  prostate tumor-overexpressed gene 1 protein isoform X1