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    KRT77 keratin 77 [ Homo sapiens (human) ]

    Gene ID: 374454, updated on 3-Dec-2024

    Summary

    Official Symbol
    KRT77provided by HGNC
    Official Full Name
    keratin 77provided by HGNC
    Primary source
    HGNC:HGNC:20411
    See related
    Ensembl:ENSG00000189182 MIM:611158; AllianceGenome:HGNC:20411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K1B; KRT1B
    Summary
    Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
    Expression
    Restricted expression toward skin (RPKM 121.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KRT77 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52689626..52703524, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52654148..52668031, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53083410..53097308, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53068684-53069184 Neighboring gene keratin 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29208 Neighboring gene keratin 126, pseudogene Neighboring gene DEAD-box helicase 23 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC148087

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 1b
    Names
    CK-1B
    K77
    cytokeratin-1B
    keratin 1B
    keratin 77, type II
    type-II keratin Kb39

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012322.1 RefSeqGene

      Range
      4940..18838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175078.3NP_778253.2  keratin, type II cytoskeletal 1b

      See identical proteins and their annotated locations for NP_778253.2

      Status: REVIEWED

      Source sequence(s)
      AC055716, BC122558
      Consensus CDS
      CCDS8837.1
      UniProtKB/Swiss-Prot
      Q7RTS8, Q7Z794
      UniProtKB/TrEMBL
      Q0IIN1
      Related
      ENSP00000342710.3, ENST00000341809.8
      Conserved Domains (3) summary
      pfam00038
      Location:163476
      Filament; Intermediate filament protein
      pfam16208
      Location:56160
      Keratin_2_head; Keratin type II head
      cl23720
      Location:384451
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52689626..52703524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538288.3XP_011536590.1  keratin, type II cytoskeletal 1b isoform X1

      UniProtKB/TrEMBL
      Q147W7
      Conserved Domains (1) summary
      pfam00038
      Location:1243
      Filament; Intermediate filament protein
    2. XM_011538289.3XP_011536591.1  keratin, type II cytoskeletal 1b isoform X2

      Conserved Domains (1) summary
      pfam16208
      Location:56160
      Keratin_2_head; Keratin type II head

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52654148..52668031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371976.1XP_054227951.1  keratin, type II cytoskeletal 1b isoform X1

      UniProtKB/TrEMBL
      Q147W7
    2. XM_054371977.1XP_054227952.1  keratin, type II cytoskeletal 1b isoform X2