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    PARVB parvin beta [ Homo sapiens (human) ]

    Gene ID: 29780, updated on 9-Dec-2024

    Summary

    Official Symbol
    PARVBprovided by HGNC
    Official Full Name
    parvin betaprovided by HGNC
    Primary source
    HGNC:HGNC:14653
    See related
    Ensembl:ENSG00000188677 MIM:608121; AllianceGenome:HGNC:14653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-56
    Summary
    This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in fat (RPKM 14.3), heart (RPKM 12.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PARVB in Genome Data Viewer
    Location:
    22q13.31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43999211..44172939)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (44483004..44656061)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (44395091..44568819)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:44319500-44320244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44320245-44320987 Neighboring gene Sharpr-MPRA regulatory region 5125 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:44347552-44347721 Neighboring gene H3K27ac hESC enhancers GRCh37_chr22:44350547-44351299 and GRCh37_chr22:44351300-44352051 Neighboring gene patatin like phospholipase domain containing 3 Neighboring gene ribosomal protein L35a pseudogene 36 Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19196 Neighboring gene uncharacterized LOC124905131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44433869-44434401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44441960-44442509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44444424-44445372 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:44447510-44448390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44451418-44451918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44459805-44460304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44463139-44463704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44463705-44464268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44464833-44465396 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:44501635-44502135 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr22:44502229-44503124 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44503125-44504019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44504020-44504914 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44541321-44541950 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44541951-44542580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44543839-44544468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44550653-44551476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44551477-44552300 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44553755-44554288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44554289-44554822 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:44556425-44556958 Neighboring gene tRNA-SeC (anticodon TCA) 2-1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44563307-44564086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44565977-44566498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44570650-44571382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44576792-44577522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44577523-44578252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44578253-44578982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44588052-44588637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44588638-44589222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44596327-44597136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44597948-44598757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44600018-44600518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44600519-44601019 Neighboring gene parvin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44616903-44617455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44658947-44659462 Neighboring gene shisa like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44676595-44677095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44678007-44678506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44685764-44686707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44688595-44689536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44694997-44695529 Neighboring gene uncharacterized LOC101927499

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.
    EBI GWAS Catalog
    Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of parvin, beta (PARVB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ17029

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of cell polarity regulating cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029743.3 RefSeqGene

      Range
      30093..178730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003828.3NP_001003828.1  beta-parvin isoform a

      See identical proteins and their annotated locations for NP_001003828.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as CLINT or ParvB3) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF237769, AF303887, AL031595, AL035398, CA308417
      Consensus CDS
      CCDS46724.1
      UniProtKB/Swiss-Prot
      Q9HBI1
      Related
      ENSP00000384515.3, ENST00000406477.7
      Conserved Domains (1) summary
      pfam00307
      Location:121222
      CH; Calponin homology (CH) domain
    2. NM_001243385.2NP_001230314.1  beta-parvin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream alternate start codon, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL031595, AL033543, BC039811, CA308417, Z82174
      Consensus CDS
      CCDS58808.1
      UniProtKB/Swiss-Prot
      Q9HBI1
      Related
      ENSP00000384353.1, ENST00000404989.1
      Conserved Domains (2) summary
      cd21336
      Location:51156
      CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
      cd21338
      Location:198327
      CH_PARVB_rpt2; second calponin homology (CH) domain found in beta-parvin
    3. NM_001243386.2NP_001230315.1  beta-parvin isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream alternate start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AF237769, AK308443, AL031595, AL033543, CA308417
      Consensus CDS
      CCDS74874.1
      UniProtKB/TrEMBL
      A0A087WZB5
      Related
      ENSP00000482511.1, ENST00000619710.4
      Conserved Domains (1) summary
      pfam00307
      Location:36137
      CH; Calponin homology (CH) domain
    4. NM_013327.5NP_037459.2  beta-parvin isoform b

      See identical proteins and their annotated locations for NP_037459.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as ParvB2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AF237769, AL031595, BP339885, CA308417
      Consensus CDS
      CCDS14056.1
      UniProtKB/Swiss-Prot
      B0QYM8, B0QYN1, B2R9X6, Q5TGJ5, Q86X93, Q96PN1, Q9HBI1, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7
      Related
      ENSP00000342492.6, ENST00000338758.12
      Conserved Domains (1) summary
      pfam00307
      Location:88189
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      43999211..44172939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452236.2XP_024308004.1  beta-parvin isoform X2

      Conserved Domains (1) summary
      pfam00307
      Location:120228
      CH; Calponin homology (CH) domain
    2. XM_017028792.3XP_016884281.1  beta-parvin isoform X3

    3. XM_024452235.2XP_024308003.1  beta-parvin isoform X1

      Conserved Domains (1) summary
      pfam00307
      Location:105213
      CH; Calponin homology (CH) domain
    4. XM_047441349.1XP_047297305.1  beta-parvin isoform X4

      Conserved Domains (2) summary
      cd21336
      Location:51156
      CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
      cd21338
      Location:198327
      CH_PARVB_rpt2; second calponin homology (CH) domain found in beta-parvin
    5. XM_047441350.1XP_047297306.1  beta-parvin isoform X6

      Conserved Domains (2) summary
      cd21336
      Location:51156
      CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
      cd21338
      Location:198327
      CH_PARVB_rpt2; second calponin homology (CH) domain found in beta-parvin
    6. XM_024452237.2XP_024308005.1  beta-parvin isoform X5

      Conserved Domains (2) summary
      cd21336
      Location:51156
      CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
      cd21338
      Location:198327
      CH_PARVB_rpt2; second calponin homology (CH) domain found in beta-parvin
    7. XM_047441351.1XP_047297307.1  beta-parvin isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      44483004..44656061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325581.1XP_054181556.1  beta-parvin isoform X2

    2. XM_054325582.1XP_054181557.1  beta-parvin isoform X3

    3. XM_054325587.1XP_054181562.1  beta-parvin isoform X7

    4. XM_054325580.1XP_054181555.1  beta-parvin isoform X1

    5. XM_054325583.1XP_054181558.1  beta-parvin isoform X4

    6. XM_054325584.1XP_054181559.1  beta-parvin isoform X5

    7. XM_054325585.1XP_054181560.1  beta-parvin isoform X6

    8. XM_054325586.1XP_054181561.1  beta-parvin isoform X7