ARID3B AT-rich interaction domain 3B [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARID3Bprovided by HGNC
Official Full Name: AT-rich interaction domain 3Bprovided by HGNC
Primary source: HGNC:HGNC:14350
See related: Ensembl:ENSG00000179361 MIM:612457; AllianceGenome:HGNC:14350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BDP; DRIL2
Summary: This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 16.7), placenta (RPKM 10.6) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q24.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (74541220..74598131)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (72408943..72468032)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (74833561..74890472)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct and overlapping roles of ARID3A and ARID3B in regulating E2Fdependent transcription via direct binding to E2F target genes.
Title: Distinct and overlapping roles of ARID3A and ARID3B in regulating E2F‑dependent transcription via direct binding to E2F target genes.
Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer.
Title: Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer.
Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients.
Title: Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients.
Knockout of LIN28A and LIN28B in ACH-3P cells not only significantly increased amounts of let-7 miRNAs but also led to significant reduction in ARID3B-complex proteins, potentially because of increased targeting by let-7 miRNAs.
Title: LIN28-let-7 axis regulates genes in immortalized human trophoblast cells by targeting the ARID3B-complex.
Study provides a comprehensive list of genes and pathways regulated by ARID3A and ARID3B in ovarian cancer cells.
Title: ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells.
A novel cellular protein (AT-rich interacting domain protein 3B [ARID3B]) that we show is able to temper lytic reactivation.
Title: ARID3B: a Novel Regulator of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle.
Data indicate that the most prominent proteins associating with Gab2 are PTPN11, PIK3R1 and ARID3B.
Title: Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes.
Although ARID3B and ARID3A share overlapping functions, ARID3B play a key role in the expression of pro-apoptotic p53-target genes and apoptosis.
Title: Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis.
ARID3B boosts production CD133+ tumor stem cells and increases ovarian cancer progression in vivo.
Title: ARID3B increases ovarian tumor burden and is associated with a cancer stem cell gene signature.
Data report a positive correlation between ER positivity and nuclear ARID3B expression in primary breast cancers, along with a negative correlation with the ERBB2 status.
Title: ARID3B expression in primary breast cancers and breast cancer-derived cell lines.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44782 (e-PCR)
- UniSTS:17159

D15S1320 (e-PCR)
- UniSTS:2882

D15S1320 (e-PCR)
- UniSTS:75344

L17911 (e-PCR)
- UniSTS:48479

SHGC-132023 (e-PCR)
- UniSTS:170606

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 3B

Names: ARID domain-containing protein 3B; AT rich interactive domain 3B (BRIGHT- like); Bright-derived protein; bright and dead ringer protein; bright-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001307939.2 → NP_001294868.1 AT-rich interactive domain-containing protein 3B isoform 1

See identical proteins and their annotated locations for NP_001294868.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC100835, AF116846, BC041792, DC396899

Consensus CDS

CCDS76777.1

UniProtKB/Swiss-Prot

O95443, Q59HC9, Q6P9C9, Q8IVW6

UniProtKB/TrEMBL

B4DQB0

Related

ENSP00000477878.1, ENST00000622429.1

Conserved Domains (1) summary

smart00501
Location:216 → 305

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
NM_006465.4 → NP_006456.1 AT-rich interactive domain-containing protein 3B isoform 2

See identical proteins and their annotated locations for NP_006456.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC100835, AF116846, DC396899

Consensus CDS

CCDS10264.1

UniProtKB/TrEMBL

B4DQB0

Related

ENSP00000343126.5, ENST00000346246.10

Conserved Domains (1) summary

smart00501
Location:216 → 305

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain