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    FNDC4 fibronectin type III domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 64838, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FNDC4provided by HGNC
    Official Full Name
    fibronectin type III domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:20239
    See related
    Ensembl:ENSG00000115226 MIM:611905; AllianceGenome:HGNC:20239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRCP1
    Summary
    Involved in response to transforming growth factor beta. Predicted to be located in endoplasmic reticulum; extracellular space; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal (RPKM 35.7), brain (RPKM 13.1) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FNDC4 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27491883..27495200, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27534239..27537558, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27714750..27718067, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27665383-27665925 Neighboring gene keratinocyte associated protein 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27676057-27677256 Neighboring gene intraflagellar transport 172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27681686-27682885 Neighboring gene RNA, U6 small nuclear 986, pseudogene Neighboring gene glucokinase regulator Neighboring gene Sharpr-MPRA regulatory region 4379 Neighboring gene SPATA31 subfamily H member 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27788766-27789965

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. FNDC4 reduces hepatocyte inflammatory cell death via AMPKα in metabolic dysfunction-associated steatotic liver disease. Neira G, et al. Clin Nutr, 2024 Sep. PMID 39173437
    2. FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes. Frühbeck G, et al. Metabolism, 2020 Jul. PMID 32407726
    3. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction. Daudon M, et al. Reproduction, 2022 May 23. PMID 35521900
    4. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes. Frühbeck G, et al. Cell Mol Immunol, 2021 Oct. PMID 34465884, Free PMC Article
    5. FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling. Xiao C, et al. Tissue Cell, 2024 Feb. PMID 38181585

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FNDC4 reduces hepatocyte inflammatory cell death via AMPKalpha in metabolic dysfunction-associated steatotic liver disease.
      Title: FNDC4 reduces hepatocyte inflammatory cell death via AMPKα in metabolic dysfunction-associated steatotic liver disease.
    2. FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.
      Title: FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.
    3. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction.
      Title: Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction.
    4. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes.
      Title: FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes.
    5. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
      Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
    6. The novel adipokine FNDC4 reduces lipogenesis and increases fat browning in human visceral adipocytes.
      Title: FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes.
    7. FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
      Title: FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    10. Reports the cloning, expression and subcellular localization of the related mouse protein.
      Title: Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
    EBI GWAS Catalog
    Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
    EBI GWAS Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog
    Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
    EBI GWAS Catalog
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22362

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to transforming growth factor beta IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 4
    Names
    fibronectin type III repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022823.3 → NP_073734.1  fibronectin type III domain-containing protein 4 precursor

      See identical proteins and their annotated locations for NP_073734.1

      Status: VALIDATED

      Source sequence(s)
      BC032725, DB452792
      Consensus CDS
      CCDS1756.1
      UniProtKB/Swiss-Prot
      D6W560, Q9H6D8
      Related
      ENSP00000264703.3, ENST00000264703.4
      Conserved Domains (1) summary
      cd00063
      Location:47 → 137
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27491883..27495200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264499.5 → XP_005264556.1  fibronectin type III domain-containing protein 4 isoform X2

      Related
      ENST00000491414.5
      Conserved Domains (1) summary
      cd00063
      Location:47 → 137
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_047445471.1 → XP_047301427.1  fibronectin type III domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W560, Q9H6D8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27534239..27537558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343401.1 → XP_054199376.1  fibronectin type III domain-containing protein 4 isoform X2

    2. XM_054343402.1 → XP_054199377.1  fibronectin type III domain-containing protein 4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H6D8.1 GenPept UniProtKB/Swiss-Prot:Q9H6D8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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