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    RGS5 regulator of G protein signaling 5 [ Homo sapiens (human) ]

    Gene ID: 8490, updated on 10-Dec-2024

    Summary

    Official Symbol
    RGS5provided by HGNC
    Official Full Name
    regulator of G protein signaling 5provided by HGNC
    Primary source
    HGNC:HGNC:10001
    See related
    Ensembl:ENSG00000143248 MIM:603276; AllianceGenome:HGNC:10001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]
    Expression
    Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RGS5 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (163142299..163321735, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (162487178..162666666, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163112089..163291525, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC124904446 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene regulator of G protein signaling 4 Neighboring gene NANOG hESC enhancer GRCh37_chr1:163101622-163102196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_592 Neighboring gene RGS5 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163172770-163173435 Neighboring gene uncharacterized LOC127814295 Neighboring gene TRNT1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2014 Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163369660-163370204 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:163384530-163384653 Neighboring gene eukaryotic translation initiation factor 3 subunit J pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (9 hits/1154 screens)

    Associated conditions

    Description Tests
    Essential hypertension, genetic
    MedGen: CN305331 OMIM: 145500 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog
    Genome-wide association study of liver enzymes in korean children.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity PubMed 
    enables GTPase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in plasma membrane  

    General protein information

    Preferred Names
    regulator of G-protein signaling 5
    Names
    regulator of G-protein signalling 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027731.2 RefSeqGene

      Range
      123876..184493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195303.3 → NP_001182232.1  regulator of G-protein signaling 5 isoform 2

      See identical proteins and their annotated locations for NP_001182232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AJ891044, AL157502, AL583850, BX537427, DA699380
      Consensus CDS
      CCDS55652.1
      UniProtKB/Swiss-Prot
      O15539
      Related
      ENSP00000432313.1, ENST00000527988.1
      Conserved Domains (1) summary
      cl02565
      Location:1 → 70
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001254748.2 → NP_001241677.1  regulator of G-protein signaling 5 isoform 2

      See identical proteins and their annotated locations for NP_001241677.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AL157502, AL583850, BP292867, BX537427
      Consensus CDS
      CCDS55652.1
      UniProtKB/Swiss-Prot
      O15539
      Related
      ENSP00000480891.1, ENST00000618415.4
      Conserved Domains (1) summary
      cl02565
      Location:1 → 70
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001254749.2 → NP_001241678.1  regulator of G-protein signaling 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
      Source sequence(s)
      AL157502, AL583850, BU172751, BX537427, DA699380
      Consensus CDS
      CCDS58041.1
      UniProtKB/TrEMBL
      B2RD05
      Related
      ENSP00000433001.1, ENST00000530507.5
      Conserved Domains (1) summary
      cd08717
      Location:65 → 182
      RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein
    4. NM_001414472.1 → NP_001401401.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05
    5. NM_001414473.1 → NP_001401402.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05
    6. NM_001414474.1 → NP_001401403.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05
    7. NM_001414475.1 → NP_001401404.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05
    8. NM_001414476.1 → NP_001401405.1  regulator of G-protein signaling 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05
    9. NM_001414477.1 → NP_001401406.1  regulator of G-protein signaling 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435
    10. NM_001414478.1 → NP_001401407.1  regulator of G-protein signaling 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435
    11. NM_001414479.1 → NP_001401408.1  regulator of G-protein signaling 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435
    12. NM_003617.4 → NP_003608.1  regulator of G-protein signaling 5 isoform 1

      See identical proteins and their annotated locations for NP_003608.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions.
      Source sequence(s)
      AL451063, AL583850, BC030059
      Consensus CDS
      CCDS1244.1
      UniProtKB/Swiss-Prot
      E9PMP5, O15539, Q53XA9, Q599J0
      UniProtKB/TrEMBL
      B2RD05
      Related
      ENSP00000319308.5, ENST00000313961.10
      Conserved Domains (1) summary
      cd08717
      Location:65 → 178
      RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      163142299..163321735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      162487178..162666666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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