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    OXCT2 3-oxoacid CoA-transferase 2 [ Homo sapiens (human) ]

    Gene ID: 64064, updated on 27-Nov-2024

    Summary

    Official Symbol
    OXCT2provided by HGNC
    Official Full Name
    3-oxoacid CoA-transferase 2provided by HGNC
    Primary source
    HGNC:HGNC:18606
    See related
    Ensembl:ENSG00000198754 MIM:610289; AllianceGenome:HGNC:18606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCOTT; FKSG25
    Summary
    The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]
    Orthologs
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    Genomic context

    See OXCT2 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (39769523..39771348, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39638968..39640793, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40235195..40237020, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 121 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 816 Neighboring gene peptidylprolyl isomerase E Neighboring gene bone morphogenetic protein 8b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40236393-40237066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40237067-40237739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40244416-40244916 Neighboring gene BMP8B antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40254643-40255144 Neighboring gene uncharacterized LOC101929536

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00030

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables succinyl-CoA:3-oxo-acid CoA-transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ketone body catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ketone body metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
    Names
    3-oxoacid CoA-transferase 2A
    testis-specific succinyl CoA:3-oxoacid CoA-transferase
    NP_071403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022120.2NP_071403.1  succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_071403.1

      Status: REVIEWED

      Source sequence(s)
      AL033527, AY013700
      Consensus CDS
      CCDS445.1
      UniProtKB/Swiss-Prot
      B2RBB4, Q5QPK4, Q8NHR1, Q9BYC2, Q9H1I4
      UniProtKB/TrEMBL
      B3KS89
      Related
      ENSP00000361914.1, ENST00000327582.5
      Conserved Domains (3) summary
      COG1788
      Location:48274
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
      COG4670
      Location:48514
      YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
      cl00339
      Location:297505
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      39769523..39771348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      39638968..39640793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)