SIRT2 sirtuin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIRT2provided by HGNC
Official Full Name: sirtuin 2provided by HGNC
Primary source: HGNC:HGNC:10886
See related: Ensembl:ENSG00000068903 MIM:604480; AllianceGenome:HGNC:10886
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIR2; SIR2L; SIR2L2
Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Expression: Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38878555..38899618, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41682611..41703673, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39369195..39390258, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer.
Title: SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer.
Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity.
Title: Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity.
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.
Title: SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.
Biophysical insights into the dimer formation of human Sirtuin 2.
Title: Biophysical insights into the dimer formation of human Sirtuin 2.
Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
Title: Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
Construction of a prediction model for postoperative prognosis in patients with resectable cholangiocarcinoma based on silence information regulator 2 expression.
Title: Construction of a prediction model for postoperative prognosis in patients with resectable cholangiocarcinoma based on silence information regulator 2 expression.
KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
Title: KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Title: FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Decoding the multifaceted interventions between human sirtuin 2 and dynamic hepatitis B viral proteins to confirm their roles in HBV replication.
Title: Decoding the multifaceted interventions between human sirtuin 2 and dynamic hepatitis B viral proteins to confirm their roles in HBV replication.
Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.
Title: Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.

Submit: New GeneRIF Correction See all GeneRIFs (217)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L18506 (e-PCR)
- UniSTS:54024

NoName (e-PCR)
- UniSTS:9484

D19S613E (e-PCR)
- UniSTS:150542

WIAF-1625 (e-PCR)
- UniSTS:76560

GDB:434012 (e-PCR)
- UniSTS:157204

D10S275 (e-PCR)
- UniSTS:147992

D11S2560 (e-PCR)
- UniSTS:37928

L17705 (e-PCR)
- UniSTS:66091

D19S697E (e-PCR)
- UniSTS:150596

L17709 (e-PCR)
- UniSTS:42599

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

SHGC-67307 (e-PCR)
- UniSTS:89991

L17971 (e-PCR)
- UniSTS:43966

D15S1390 (e-PCR)
- UniSTS:474340

D11S3316 (e-PCR)
- UniSTS:152558

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables NAD+-protein ADP-ribosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables NAD-dependent protein demyristoylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein depalmitoylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	TAS Traceable Author Statement more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
NOT enables histone deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein lysine deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables tubulin deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caloric restriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epinephrine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	NAS Non-traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic nuclear membrane reassembly	TAS Traceable Author Statement more info
involved_in myelination in peripheral nervous system	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oligodendrocyte progenitor proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of satellite cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of striated muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rDNA heterochromatin formation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of exit from mitosis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in response to redox state	NAS Non-traceable Author Statement more info	PubMed
involved_in substantia nigra development	HEP more info	PubMed
involved_in subtelomeric heterochromatin formation	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin silencing complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in juxtaparanode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral loop	ISS Inferred from Sequence or Structural Similarity more info
located_in meiotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HTP more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in paranodal junction	ISS Inferred from Sequence or Structural Similarity more info
located_in paranode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-2

Names: NAD-dependent deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; regulatory protein SIR2 homolog 2; silent information regulator 2; sir2-related protein type 2; sirtuin type 2

NP_001180215.1

EC 2.3.1.286

NP_036369.2

EC 2.3.1.286

NP_085096.1

EC 2.3.1.286

XP_011524957.1

EC 2.3.1.286

XP_047294424.1

EC 2.3.1.286

XP_047294425.1

EC 2.3.1.286

XP_054176249.1

EC 2.3.1.286

XP_054176250.1

EC 2.3.1.286

XP_054176251.1

EC 2.3.1.286

XP_054187933.1

EC 2.3.1.286

XP_054187934.1

EC 2.3.1.286

XP_054187935.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193286.2 → NP_001180215.1 NAD-dependent protein deacetylase sirtuin-2 isoform 3

See identical proteins and their annotated locations for NP_001180215.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, and also lacks a big segment in the 3' region, resulting in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, and a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AF131800, BF529906, DA541045

Consensus CDS

CCDS74361.1

UniProtKB/TrEMBL

A0A0A0MRF5, E7EWX6

Related

ENSP00000351809.6, ENST00000358931.9

Conserved Domains (1) summary

cd01408
Location:40 → 228

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
NM_012237.4 → NP_036369.2 NAD-dependent protein deacetylase sirtuin-2 isoform 1

See identical proteins and their annotated locations for NP_036369.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF083107, BF529906

Consensus CDS

CCDS12523.1

UniProtKB/Swiss-Prot

A8K3V1, B2RB45, O95889, Q8IXJ6, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9, U5TP13

UniProtKB/TrEMBL

A0AAG2T947

Related

ENSP00000249396.7, ENST00000249396.12

Conserved Domains (1) summary

cd01408
Location:77 → 331

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_030593.3 → NP_085096.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2

See identical proteins and their annotated locations for NP_085096.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

BC003012

Consensus CDS

CCDS46069.1

UniProtKB/TrEMBL

A0AAG2T947

Related

ENSP00000375931.2, ENST00000392081.6

Conserved Domains (2) summary

cd01408
Location:40 → 294

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

pfam16602
Location:313 → 351

USP19_linker; Linker region of USP19 deubiquitinase

RNA

NR_034146.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks the 5' two exons but has an alternate 5' segment, resulting in an upstream open reading frame (uORF) with strong Kozak signal, as compared to variant 1. The uORF overlaps the downstream ORF (dORF), and inhibits the protein translation from the dORF. Therefore, this transcript is a nonsense-mediated mRNA decay candidate and can not make a functional protein.

Source sequence(s)

AK290716, BF346568, BF529906

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

38878555..38899618 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011526655.2 → XP_011524957.1 NAD-dependent protein deacetylase sirtuin-2 isoform X2

See identical proteins and their annotated locations for XP_011524957.1

UniProtKB/Swiss-Prot

Q8IXJ6

Conserved Domains (2) summary

cd01408
Location:7 → 261

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

pfam16602
Location:280 → 318

USP19_linker; Linker region of USP19 deubiquitinase
XM_047438468.1 → XP_047294424.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1
XM_047438469.1 → XP_047294425.1 NAD-dependent protein deacetylase sirtuin-2 isoform X3

Reference GRCh38.p14 PATCHES

Genomic

NW_014040929.1 Reference GRCh38.p14 PATCHES

Range

288227..309290 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331959.1 → XP_054187934.1 NAD-dependent protein deacetylase sirtuin-2 isoform X2
XM_054331958.1 → XP_054187933.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1
XM_054331960.1 → XP_054187935.1 NAD-dependent protein deacetylase sirtuin-2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

41682611..41703673 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320275.1 → XP_054176250.1 NAD-dependent protein deacetylase sirtuin-2 isoform X2
XM_054320274.1 → XP_054176249.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1
XM_054320276.1 → XP_054176251.1 NAD-dependent protein deacetylase sirtuin-2 isoform X3