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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_041821.1 RefSeqGene
- Range
-
5033..23364
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001190799.2 → NP_001177728.1 serine/threonine-protein kinase PLK4 isoform 2
See identical proteins and their annotated locations for NP_001177728.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate 5' coding exon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AI088969, AK303399, BU633758, DC402409
- Consensus CDS
-
CCDS54803.1
- UniProtKB/TrEMBL
-
J3KR84
- Related
- ENSP00000427554.1, ENST00000513090.5
- Conserved Domains (5) summary
-
- smart00220
Location:12 → 233
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd13114
Location:555 → 666
- POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13115
Location:667 → 775
- POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13116
Location:852 → 931
- POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cl21453
Location:10 → 233
- PKc_like; Protein Kinases, catalytic domain
-
NM_001190801.2 → NP_001177730.1 serine/threonine-protein kinase PLK4 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains a different first exon, which results in the use of a in-frame downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
- Source sequence(s)
-
AC107053, AI088969, AK302858, BC036023, BU633758
- Consensus CDS
-
CCDS54804.1
- UniProtKB/TrEMBL
-
J3KR84
- Related
- ENSP00000423582.1, ENST00000514379.5
- Conserved Domains (5) summary
-
- smart00220
Location:1 → 224
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd13114
Location:546 → 657
- POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13115
Location:658 → 766
- POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13116
Location:843 → 922
- POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cl21453
Location:1 → 224
- PKc_like; Protein Kinases, catalytic domain
-
NM_014264.5 → NP_055079.3 serine/threonine-protein kinase PLK4 isoform 1
See identical proteins and their annotated locations for NP_055079.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
- Source sequence(s)
-
AI088969, BC036023, BU633758
- Consensus CDS
-
CCDS3735.1
- UniProtKB/Swiss-Prot
- B2RAL0, B7Z837, B7Z8G7, O00444, Q8IYF0, Q96Q95, Q9UD84, Q9UDE2
- UniProtKB/TrEMBL
-
J3KR84
- Related
- ENSP00000270861.5, ENST00000270861.10
- Conserved Domains (5) summary
-
- smart00220
Location:12 → 265
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd13114
Location:587 → 698
- POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13115
Location:699 → 807
- POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13116
Location:884 → 963
- POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd14186
Location:10 → 265
- STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000004.12 Reference GRCh38.p14 Primary Assembly
- Range
-
127880893..127899224
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005262701.4 → XP_005262758.1 serine/threonine-protein kinase PLK4 isoform X3
- UniProtKB/TrEMBL
-
J3KR84
- Related
- ENSP00000423412.1, ENST00000507249.5
- Conserved Domains (5) summary
-
- smart00220
Location:12 → 265
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd13114
Location:553 → 664
- POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13115
Location:665 → 773
- POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd13116
Location:850 → 929
- POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
- cd14186
Location:10 → 265
- STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
-
XM_017007662.2 → XP_016863151.1 serine/threonine-protein kinase PLK4 isoform X1
- UniProtKB/TrEMBL
-
J3KR84
-
XM_017007663.3 → XP_016863152.1 serine/threonine-protein kinase PLK4 isoform X2
- UniProtKB/TrEMBL
-
J3KR84
Alternate T2T-CHM13v2.0
Genomic
-
NC_060928.1 Alternate T2T-CHM13v2.0
- Range
-
131183905..131202250
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054348797.1 → XP_054204772.1 serine/threonine-protein kinase PLK4 isoform X3
- UniProtKB/TrEMBL
-
J3KR84
-
XM_054348796.1 → XP_054204771.1 serine/threonine-protein kinase PLK4 isoform X2
- UniProtKB/TrEMBL
-
J3KR84
-
XM_054348795.1 → XP_054204770.1 serine/threonine-protein kinase PLK4 isoform X1
- UniProtKB/TrEMBL
-
J3KR84