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    PLK4 polo like kinase 4 [ Homo sapiens (human) ]

    Gene ID: 10733, updated on 3-Dec-2024

    Summary

    Official Symbol
    PLK4provided by HGNC
    Official Full Name
    polo like kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:11397
    See related
    Ensembl:ENSG00000142731 MIM:605031; AllianceGenome:HGNC:11397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAK; STK18; MCCRP2
    Summary
    This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in testis (RPKM 12.2), bone marrow (RPKM 8.2) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLK4 in Genome Data Viewer
    Location:
    4q28.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (127880893..127899224)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (131183905..131202250)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128802048..128820379)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SOSS complex subunit C-like Neighboring gene heat shock protein family A (Hsp70) member 4 like Neighboring gene ribosomal protein L21 pseudogene 53 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:128767199-128767740 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21887 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73815 Neighboring gene RNA, U6 small nuclear 583, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73859 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15676 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128886145-128886760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:128887439-128887940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:128887941-128888440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15679 Neighboring gene abhydrolase domain containing 18 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73920 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73968 Neighboring gene H3K27ac hESC enhancers GRCh37_chr4:128981832-128982690 and GRCh37_chr4:128982691-128983549 Neighboring gene La ribonucleoprotein 1B Neighboring gene ribosomal protein L15 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in XY body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in deuterosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in procentriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of procentriole replication complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase PLK4
    Names
    Snk akin kinase
    serine/threonine-protein kinase 18
    serine/threonine-protein kinase Sak
    NP_001177728.1
    NP_001177730.1
    NP_055079.3
    XP_005262758.1
    XP_016863151.1
    XP_016863152.1
    XP_054204770.1
    XP_054204771.1
    XP_054204772.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041821.1 RefSeqGene

      Range
      5033..23364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190799.2NP_001177728.1  serine/threonine-protein kinase PLK4 isoform 2

      See identical proteins and their annotated locations for NP_001177728.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' coding exon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI088969, AK303399, BU633758, DC402409
      Consensus CDS
      CCDS54803.1
      UniProtKB/TrEMBL
      J3KR84
      Related
      ENSP00000427554.1, ENST00000513090.5
      Conserved Domains (5) summary
      smart00220
      Location:12233
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:555666
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:667775
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:852931
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cl21453
      Location:10233
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001190801.2NP_001177730.1  serine/threonine-protein kinase PLK4 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a different first exon, which results in the use of a in-frame downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC107053, AI088969, AK302858, BC036023, BU633758
      Consensus CDS
      CCDS54804.1
      UniProtKB/TrEMBL
      J3KR84
      Related
      ENSP00000423582.1, ENST00000514379.5
      Conserved Domains (5) summary
      smart00220
      Location:1224
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:546657
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:658766
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:843922
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cl21453
      Location:1224
      PKc_like; Protein Kinases, catalytic domain
    3. NM_014264.5NP_055079.3  serine/threonine-protein kinase PLK4 isoform 1

      See identical proteins and their annotated locations for NP_055079.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AI088969, BC036023, BU633758
      Consensus CDS
      CCDS3735.1
      UniProtKB/Swiss-Prot
      B2RAL0, B7Z837, B7Z8G7, O00444, Q8IYF0, Q96Q95, Q9UD84, Q9UDE2
      UniProtKB/TrEMBL
      J3KR84
      Related
      ENSP00000270861.5, ENST00000270861.10
      Conserved Domains (5) summary
      smart00220
      Location:12265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:587698
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:699807
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:884963
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      127880893..127899224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262701.4XP_005262758.1  serine/threonine-protein kinase PLK4 isoform X3

      UniProtKB/TrEMBL
      J3KR84
      Related
      ENSP00000423412.1, ENST00000507249.5
      Conserved Domains (5) summary
      smart00220
      Location:12265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:553664
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:665773
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:850929
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
    2. XM_017007662.2XP_016863151.1  serine/threonine-protein kinase PLK4 isoform X1

      UniProtKB/TrEMBL
      J3KR84
    3. XM_017007663.3XP_016863152.1  serine/threonine-protein kinase PLK4 isoform X2

      UniProtKB/TrEMBL
      J3KR84

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      131183905..131202250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348797.1XP_054204772.1  serine/threonine-protein kinase PLK4 isoform X3

      UniProtKB/TrEMBL
      J3KR84
    2. XM_054348796.1XP_054204771.1  serine/threonine-protein kinase PLK4 isoform X2

      UniProtKB/TrEMBL
      J3KR84
    3. XM_054348795.1XP_054204770.1  serine/threonine-protein kinase PLK4 isoform X1

      UniProtKB/TrEMBL
      J3KR84