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    ATG14 autophagy related 14 [ Homo sapiens (human) ]

    Gene ID: 22863, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ATG14provided by HGNC
    Official Full Name
    autophagy related 14provided by HGNC
    Primary source
    HGNC:HGNC:19962
    See related
    Ensembl:ENSG00000126775 MIM:613515; AllianceGenome:HGNC:19962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG14L; BARKOR; KIAA0831
    Summary
    Enables GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Involved in several processes, including early endosome to late endosome transport; macroautophagy; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Part of phosphatidylinositol 3-kinase complex, class III. Is active in phagophore assembly site. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATG14 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55366391..55411830, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49572142..49617561, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55833109..55878548, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene F-box protein 34 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:55754571-55754700 Neighboring gene ribosomal protein L34 pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 9702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8430 Neighboring gene charged multivesicular body protein 4B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8431 Neighboring gene NANOG hESC enhancer GRCh37_chr14:55794909-55795410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8432 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5783 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene TATA-box binding protein like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. Matsunaga K, et al. J Cell Biol, 2010 Aug 23. PMID 20713597, Free PMC Article
    2. Silencing of Barkor/ATG14 sensitizes osteosarcoma cells to cisplatin‑induced apoptosis. Zhao Z, et al. Int J Mol Med, 2014 Feb. PMID 24337183, Free PMC Article
    3. ATG4 promotes cell proliferation, migration and invasion in HCC and predicts a poor prognosis. Zhu XJ, et al. Eur Rev Med Pharmacol Sci, 2020 Dec. PMID 33378015
    4. Streptococcus pneumoniae promotes its own survival via choline-binding protein CbpC-mediated degradation of ATG14. Shizukuishi S, et al. Autophagy, 2020 Aug. PMID 32508214, Free PMC Article
    5. CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis. Zhao Z, et al. Immunol Res, 2022 Jun. PMID 35066780

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
      Title: Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
    2. KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
      Title: KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
    3. ATG14 plays a critical role in hepatic lipid droplet homeostasis.
      Title: ATG14 plays a critical role in hepatic lipid droplet homeostasis.
    4. CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.
      Title: CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.
    5. ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
      Title: ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
    6. Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.
      Title: Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.
    7. HIF-1alpha-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
      Title: HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
    8. SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
      Title: SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
    9. [miR-148b-3p inhibits the proliferation and autophagy of acute myeloid leukemia cells by targeting ATG14].
      Title: [miR-148b-3p inhibits the proliferation and autophagy of acute myeloid leukemia cells by targeting ATG14].
    10. [MicroRNA-424 inhibits autophagy and proliferation of hepatocellular carcinoma cells by targeting ATG14].
      Title: [MicroRNA-424 inhibits autophagy and proliferation of hepatocellular carcinoma cells by targeting ATG14].
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ATG14 autophagy related 14 homolog (S. cerevisiae, ATG14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0831, MGC126291, MGC126292

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagosome membrane docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome membrane docking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within endosome to lysosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to lysosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein complex stability IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mitochondrial depolarisation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extrinsic component of omegasome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of omegasome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    beclin 1-associated autophagy-related key regulator
    Names
    ATG14 autophagy related 14 homolog
    Beclin 1-Interacting protein
    autophagy-related protein 14-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014924.5 → NP_055739.2  beclin 1-associated autophagy-related key regulator

      See identical proteins and their annotated locations for NP_055739.2

      Status: VALIDATED

      Source sequence(s)
      AA988343, AK131251, AL158801
      Consensus CDS
      CCDS32087.1
      UniProtKB/Swiss-Prot
      A6NJE4, A8K9U5, B7ZWP5, O94920, Q32MK7, Q32MK8, Q6ZNE5
      Related
      ENSP00000247178.5, ENST00000247178.6
      Conserved Domains (1) summary
      pfam10186
      Location:43 → 388
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      55366391..55411830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536563.3 → XP_011534865.1  beclin 1-associated autophagy-related key regulator isoform X1

      See identical proteins and their annotated locations for XP_011534865.1

      UniProtKB/Swiss-Prot
      Q6ZNE5
      Related
      ENST00000558189.1
      Conserved Domains (1) summary
      pfam10186
      Location:1 → 275
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      49572142..49617561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375578.1 → XP_054231553.1  beclin 1-associated autophagy-related key regulator isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZNE5.1 GenPept UniProtKB/Swiss-Prot:Q6ZNE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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