U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DDIAS DNA damage induced apoptosis suppressor [ Homo sapiens (human) ]

    Gene ID: 220042, updated on 27-Nov-2024

    Summary

    Official Symbol
    DDIASprovided by HGNC
    Official Full Name
    DNA damage induced apoptosis suppressorprovided by HGNC
    Primary source
    HGNC:HGNC:26351
    See related
    Ensembl:ENSG00000165490 MIM:618045; AllianceGenome:HGNC:26351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    noxin; C11orf82
    Summary
    Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and regulation of DNA stability. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.9), lymph node (RPKM 1.9) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DDIAS in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (82901736..82934659)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (82825989..82871120)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82612778..82645701)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene prolylcarboxypeptidase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:82569102-82570301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5335 Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene uncharacterized LOC124902602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5337 Neighboring gene ribosomal protein L7a pseudogene 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5340 Neighboring gene RAB30, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5341 Neighboring gene small nucleolar RNA, H/ACA box 70E

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13936, FLJ25416, FLJ38838

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DNA damage-induced apoptosis suppressor protein
    Names
    nitric oxide-inducible gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363481.2NP_001350410.1  DNA damage-induced apoptosis suppressor protein

      Status: VALIDATED

      Source sequence(s)
      AP001646
      Consensus CDS
      CCDS8263.1
      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Related
      ENSP00000329930.4, ENST00000329143.4
      Conserved Domains (1) summary
      cl09930
      Location:8130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    2. NM_145018.4NP_659455.3  DNA damage-induced apoptosis suppressor protein

      See identical proteins and their annotated locations for NP_659455.3

      Status: VALIDATED

      Source sequence(s)
      AA477171, AK096157, BC039268, DB023053, DB454086
      Consensus CDS
      CCDS8263.1
      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Related
      ENSP00000435421.1, ENST00000533655.6
      Conserved Domains (1) summary
      cl09930
      Location:8130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      82901736..82934659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448400.2XP_024304168.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Conserved Domains (1) summary
      cl09930
      Location:8130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    2. XM_011544836.3XP_011543138.1  DNA damage-induced apoptosis suppressor protein isoform X1

      See identical proteins and their annotated locations for XP_011543138.1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Conserved Domains (1) summary
      cl09930
      Location:8130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    3. XM_011544837.2XP_011543139.1  DNA damage-induced apoptosis suppressor protein isoform X2

      See identical proteins and their annotated locations for XP_011543139.1

      UniProtKB/TrEMBL
      B4DMA1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      82825989..82871120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368021.1XP_054223996.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
    2. XM_054368019.1XP_054223994.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
    3. XM_054368022.1XP_054223997.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
    4. XM_054368020.1XP_054223995.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
    5. XM_054368023.1XP_054223998.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
    6. XM_054368024.1XP_054223999.1  DNA damage-induced apoptosis suppressor protein isoform X2

      UniProtKB/TrEMBL
      B4DMA1