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    IL37 interleukin 37 [ Homo sapiens (human) ]

    Gene ID: 27178, updated on 27-Nov-2024

    Summary

    Official Symbol
    IL37provided by HGNC
    Official Full Name
    interleukin 37provided by HGNC
    Primary source
    HGNC:HGNC:15563
    See related
    Ensembl:ENSG00000125571 MIM:605510; AllianceGenome:HGNC:15563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIL1; FIL1Z; IL-1H; IL-23; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward skin (RPKM 8.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL37 in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (112911165..112918882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113337679..113345401)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113668742..113676459)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373563 Neighboring gene uncharacterized LOC124906068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16408 Neighboring gene cyclin dependent kinase 8 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11877 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 23 Neighboring gene interleukin 36 gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive
    MedGen: C5444224 OMIM: 619398 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association study of lung function phenotypes in a founder population.
    EBI GWAS Catalog
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-1 receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables interleukin-1 receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-37
    Names
    FIL1 zeta
    IL-1 zeta
    IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
    IL-1X protein
    IL1F7 (canonical product IL-1F7b)
    interleukin 1 family member 7
    interleukin 1, zeta
    interleukin-1 homolog 4
    interleukin-1 superfamily z
    interleukin-1-related protein
    interleukin-23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029219.1 RefSeqGene

      Range
      3195..10912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014439.4NP_055254.2  interleukin-37 isoform 1

      See identical proteins and their annotated locations for NP_055254.2

      Status: REVIEWED

      Source sequence(s)
      AC079753
      Consensus CDS
      CCDS2103.1
      UniProtKB/Swiss-Prot
      B5BU97, Q56AP9, Q8TD04, Q8TD05, Q9HBF2, Q9HBF3, Q9NZH6, Q9UHA6
      UniProtKB/TrEMBL
      Q7RU00
      Related
      ENSP00000263326.3, ENST00000263326.8
      Conserved Domains (1) summary
      cl00094
      Location:59204
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_173202.2NP_775294.1  interleukin-37 isoform 2

      See identical proteins and their annotated locations for NP_775294.1

      Status: REVIEWED

      Source sequence(s)
      AC079753
      Consensus CDS
      CCDS2104.1
      UniProtKB/TrEMBL
      Q7RU00
      Related
      ENSP00000263327.3, ENST00000352179.7
      Conserved Domains (1) summary
      cl00094
      Location:38183
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    3. NM_173203.2NP_775295.1  interleukin-37 isoform 3

      See identical proteins and their annotated locations for NP_775295.1

      Status: REVIEWED

      Source sequence(s)
      AC079753
      Consensus CDS
      CCDS2105.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000263328.3, ENST00000349806.7
      Conserved Domains (1) summary
      cl00094
      Location:47143
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    4. NM_173204.2NP_775296.1  interleukin-37 isoform 4

      See identical proteins and their annotated locations for NP_775296.1

      Status: REVIEWED

      Source sequence(s)
      AC079753
      Consensus CDS
      CCDS2106.1
      UniProtKB/TrEMBL
      Q7RU00
      Related
      ENSP00000309208.3, ENST00000353225.7
      Conserved Domains (1) summary
      cl00094
      Location:68164
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    5. NM_173205.2NP_775297.1  interleukin-37 isoform 5

      See identical proteins and their annotated locations for NP_775297.1

      Status: REVIEWED

      Source sequence(s)
      AC079753
      Consensus CDS
      CCDS2107.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000309883.2, ENST00000311328.2
      Conserved Domains (1) summary
      cl00094
      Location:33178
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      112911165..112918882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      113337679..113345401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)