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    COTL1 coactosin like F-actin binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 23406, updated on 9-Dec-2024

    Summary

    Official Symbol
    COTL1provided by HGNC
    Official Full Name
    coactosin like F-actin binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:18304
    See related
    Ensembl:ENSG00000103187 MIM:606748; AllianceGenome:HGNC:18304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLP
    Summary
    This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See COTL1 in Genome Data Viewer
    Location:
    16q24.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (84565596..84618078, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (90631897..90684371, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84599202..84651684, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84538296-84539243 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:84540344-84540580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84540853-84541353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84543104-84543903 Neighboring gene uncharacterized LOC124903735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84547599-84548206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84557586-84558169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84558170-84558754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84565360-84566037 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:84565033-84565246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:84566038-84566716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:84566717-84567393 Neighboring gene Sharpr-MPRA regulatory region 4738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84577753-84578254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84578255-84578754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84580244-84580995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84580996-84581746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84582498-84583247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84589034-84589534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84593245-84593762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84594827-84595594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84595595-84596362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84605929-84606461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84617304-84617809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84623933-84624432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84631141-84631642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84631643-84632142 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84632885-84633706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11245 Neighboring gene Sharpr-MPRA regulatory region 4329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84637045-84637609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84647291-84647792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84647793-84648292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84674539-84675097 Neighboring gene uncharacterized LOC105371376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7790 Neighboring gene kelch like family member 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84706085-84706586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84745056-84745556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84752587-84753087 Neighboring gene Sharpr-MPRA regulatory region 11774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11253 Neighboring gene ubiquitin specific peptidase 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:84760363-84760863 Neighboring gene uncharacterized LOC124903737

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43657, MGC19733

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    coactosin-like protein
    Names
    coactosin-like 1
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021149.5NP_066972.1  coactosin-like protein

      See identical proteins and their annotated locations for NP_066972.1

      Status: REVIEWED

      Source sequence(s)
      AC022165, AC092145
      Consensus CDS
      CCDS10947.1
      UniProtKB/Swiss-Prot
      B2RDU3, D3DUL9, Q14019, Q86XM5
      UniProtKB/TrEMBL
      A0A384MTY2
      Related
      ENSP00000262428.4, ENST00000262428.5
      Conserved Domains (1) summary
      cd11282
      Location:9120
      ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      84565596..84618078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      90631897..90684371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)