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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008873.1 RefSeqGene
- Range
-
5413..120795
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001306177.2 → NP_001293106.1 rho guanine nucleotide exchange factor 6 isoform 2
See identical proteins and their annotated locations for NP_001293106.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks two 5' exons and contains an alternate 5' terminal exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
- Source sequence(s)
-
AK294929, AK295709, AL135783, BC033768
- Consensus CDS
-
CCDS78509.1
- UniProtKB/TrEMBL
-
B7Z3C7
- Related
- ENSP00000359654.1, ENST00000370620.5
- Conserved Domains (6) summary
-
- cd12060
Location:8 → 65
- SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
- cd00160
Location:88 → 265
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:296 → 393
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:313 → 394
- PH; PH domain
- pfam16523
Location:527 → 613
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:419 → 524
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
-
NM_004840.3 → NP_004831.1 rho guanine nucleotide exchange factor 6 isoform 1
See identical proteins and their annotated locations for NP_004831.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
BC033768, BC039856
- Consensus CDS
-
CCDS14660.1
- UniProtKB/Swiss-Prot
- A6NMW9, A8K6S7, B1AL37, Q15052, Q15396, Q5JQ66, Q7Z3W1, Q86XH0
- UniProtKB/TrEMBL
-
A0A2X0SSH0
- Related
- ENSP00000250617.6, ENST00000250617.7
- Conserved Domains (8) summary
-
- cd12060
Location:162 → 219
- SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
- cd00160
Location:242 → 419
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:450 → 547
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:467 → 548
- PH; PH domain
- pfam00307
Location:3 → 105
- CH; Calponin homology (CH) domain
- pfam16523
Location:681 → 767
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:573 → 678
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:115 → 160
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000023.11 Reference GRCh38.p14 Primary Assembly
- Range
-
136665550..136780932 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005262499.4 → XP_005262556.1 rho guanine nucleotide exchange factor 6 isoform X6
- UniProtKB/TrEMBL
-
A0A2X0SSH0
- Conserved Domains (8) summary
-
- cd12060
Location:162 → 219
- SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
- cd00160
Location:242 → 419
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:450 → 547
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:467 → 548
- PH; PH domain
- pfam00307
Location:3 → 105
- CH; Calponin homology (CH) domain
- pfam16523
Location:632 → 718
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:572 → 629
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:115 → 160
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
-
XM_047442672.1 → XP_047298628.1 rho guanine nucleotide exchange factor 6 isoform X4
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_011531413.3 → XP_011529715.1 rho guanine nucleotide exchange factor 6 isoform X3
- UniProtKB/TrEMBL
-
A0A2X0SSH0
- Conserved Domains (8) summary
-
- cd12060
Location:162 → 219
- SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
- cd00160
Location:242 → 419
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:450 → 547
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:467 → 548
- PH; PH domain
- pfam00307
Location:3 → 105
- CH; Calponin homology (CH) domain
- pfam16523
Location:685 → 771
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:578 → 682
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:115 → 160
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
-
XM_011531412.4 → XP_011529714.1 rho guanine nucleotide exchange factor 6 isoform X2
- UniProtKB/TrEMBL
-
A0A2X0SSH0
- Conserved Domains (8) summary
-
- cd12060
Location:162 → 219
- SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
- cd00160
Location:269 → 446
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:477 → 574
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:494 → 575
- PH; PH domain
- pfam00307
Location:3 → 105
- CH; Calponin homology (CH) domain
- pfam16523
Location:708 → 794
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:600 → 705
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:115 → 160
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
-
XM_017029975.3 → XP_016885464.1 rho guanine nucleotide exchange factor 6 isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_047442675.1 → XP_047298631.1 rho guanine nucleotide exchange factor 6 isoform X9
- UniProtKB/TrEMBL
-
B7Z3C7
-
XM_047442674.1 → XP_047298630.1 rho guanine nucleotide exchange factor 6 isoform X8
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_047442673.1 → XP_047298629.1 rho guanine nucleotide exchange factor 6 isoform X7
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_011531415.3 → XP_011529717.1 rho guanine nucleotide exchange factor 6 isoform X5
- UniProtKB/TrEMBL
-
A0A2X0SSH0
- Conserved Domains (7) summary
-
- cd12060
Location:105 → 162
- SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
- cd00160
Location:212 → 389
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:420 → 517
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:437 → 518
- PH; PH domain
- pfam16523
Location:651 → 737
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:543 → 648
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:58 → 103
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
Alternate T2T-CHM13v2.0
Genomic
-
NC_060947.1 Alternate T2T-CHM13v2.0
- Range
-
134974276..135089655 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054328173.1 → XP_054184148.1 rho guanine nucleotide exchange factor 6 isoform X6
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328171.1 → XP_054184146.1 rho guanine nucleotide exchange factor 6 isoform X4
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328170.1 → XP_054184145.1 rho guanine nucleotide exchange factor 6 isoform X3
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328169.1 → XP_054184144.1 rho guanine nucleotide exchange factor 6 isoform X2
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328168.1 → XP_054184143.1 rho guanine nucleotide exchange factor 6 isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328176.1 → XP_054184151.1 rho guanine nucleotide exchange factor 6 isoform X9
- UniProtKB/TrEMBL
-
B7Z3C7
-
XM_054328175.1 → XP_054184150.1 rho guanine nucleotide exchange factor 6 isoform X8
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328174.1 → XP_054184149.1 rho guanine nucleotide exchange factor 6 isoform X7
- UniProtKB/TrEMBL
-
A0A2X0SSH0
-
XM_054328172.1 → XP_054184147.1 rho guanine nucleotide exchange factor 6 isoform X5
- UniProtKB/TrEMBL
-
A0A2X0SSH0