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    MELK maternal embryonic leucine zipper kinase [ Homo sapiens (human) ]

    Gene ID: 9833, updated on 3-Dec-2024

    Summary

    Official Symbol
    MELKprovided by HGNC
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:16870
    See related
    Ensembl:ENSG00000165304 MIM:607025; AllianceGenome:HGNC:16870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPK38
    Summary
    Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MELK in Genome Data Viewer
    Location:
    9p13.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36572895..36677682)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36595568..36700421)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36572892..36677679)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724322 Neighboring gene high mobility group box 3 pseudogene 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36391761-36392261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19893 Neighboring gene uncharacterized LOC124902152 Neighboring gene ring finger protein 38 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:36415685-36416307 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28351 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36482565-36482744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:36558262-36558872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36571611-36572110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36584821-36585797 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36596422-36596589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36725931-36726432 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:36738402-36739601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19897 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36756569-36756775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36764829-36765347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36764310-36764828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28356 Neighboring gene uncharacterized LOC105376030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36820286-36820786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36848015-36848854 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:36851359-36852558 Neighboring gene microRNA 4475 Neighboring gene paired box 5 Neighboring gene microRNA 4540

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0175

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    maternal embryonic leucine zipper kinase
    Names
    pEg3 kinase
    protein kinase Eg3
    protein kinase PK38
    tyrosine-protein kinase MELK
    NP_001243614.1
    NP_001243616.1
    NP_001243617.1
    NP_001243618.1
    NP_001243619.1
    NP_001243620.1
    NP_001243621.1
    NP_001243622.1
    NP_055606.1
    XP_011516378.1
    XP_011516379.1
    XP_011516382.1
    XP_011516383.1
    XP_011516384.1
    XP_011516387.1
    XP_047280122.1
    XP_047280124.1
    XP_047280125.1
    XP_047280126.1
    XP_047280127.1
    XP_047280128.1
    XP_047280129.1
    XP_047280130.1
    XP_047280132.1
    XP_047280133.1
    XP_047280134.1
    XP_047280135.1
    XP_047280136.1
    XP_047280137.1
    XP_047280138.1
    XP_047280139.1
    XP_047280140.1
    XP_047280141.1
    XP_047280142.1
    XP_047280143.1
    XP_047280144.1
    XP_047280145.1
    XP_047280147.1
    XP_047280148.1
    XP_047280149.1
    XP_047280150.1
    XP_047280151.1
    XP_047280152.1
    XP_047280153.1
    XP_047280154.1
    XP_047280155.1
    XP_047280156.1
    XP_047280158.1
    XP_047280159.1
    XP_047280160.1
    XP_047280161.1
    XP_047280162.1
    XP_054220272.1
    XP_054220273.1
    XP_054220274.1
    XP_054220275.1
    XP_054220276.1
    XP_054220277.1
    XP_054220278.1
    XP_054220279.1
    XP_054220280.1
    XP_054220281.1
    XP_054220282.1
    XP_054220283.1
    XP_054220284.1
    XP_054220285.1
    XP_054220286.1
    XP_054220287.1
    XP_054220288.1
    XP_054220289.1
    XP_054220290.1
    XP_054220291.1
    XP_054220292.1
    XP_054220293.1
    XP_054220294.1
    XP_054220295.1
    XP_054220296.1
    XP_054220297.1
    XP_054220298.1
    XP_054220299.1
    XP_054220300.1
    XP_054220301.1
    XP_054220302.1
    XP_054220303.1
    XP_054220304.1
    XP_054220305.1
    XP_054220306.1
    XP_054220307.1
    XP_054220308.1
    XP_054220309.1
    XP_054220310.1
    XP_054220311.1
    XP_054220312.1
    XP_054220313.1
    XP_054220314.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256685.2NP_001243614.1  maternal embryonic leucine zipper kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI590871, AK299164, BC014039, BP365611
      Consensus CDS
      CCDS59123.1
      UniProtKB/TrEMBL
      Q53GX0
      Related
      ENSP00000437804.1, ENST00000541717.4
      Conserved Domains (4) summary
      cd12198
      Location:514608
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    2. NM_001256687.2NP_001243616.1  maternal embryonic leucine zipper kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AI590871, AK300761, BC014039, BP365611
      Consensus CDS
      CCDS59124.1
      UniProtKB/TrEMBL
      Q53GX0
      Related
      ENSP00000439792.1, ENST00000536860.5
      Conserved Domains (4) summary
      cd12198
      Location:507601
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11215
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:233284
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7215
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001256688.2NP_001243617.1  maternal embryonic leucine zipper kinase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AI590871, AK293284, BC014039, BP365611
      Consensus CDS
      CCDS59125.1
      UniProtKB/TrEMBL
      Q53GX0
      Related
      ENSP00000445452.1, ENST00000545008.5
      Conserved Domains (4) summary
      cd12198
      Location:484578
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11192
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:210261
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7192
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001256689.2NP_001243618.1  maternal embryonic leucine zipper kinase isoform 5

      See identical proteins and their annotated locations for NP_001243618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) initiates translation at an alternate start codon and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB183427, AI590871, BP365611
      Consensus CDS
      CCDS59126.1
      UniProtKB/TrEMBL
      Q53GX0
      Related
      ENSP00000441596.1, ENST00000543751.5
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001256690.2NP_001243619.1  maternal embryonic leucine zipper kinase isoform 6

      See identical proteins and their annotated locations for NP_001243619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB183428, AI590871, BP365611
      Consensus CDS
      CCDS59127.1
      UniProtKB/TrEMBL
      Q53GX0
      Related
      ENSP00000443550.1, ENST00000536329.5
      Conserved Domains (4) summary
      cd12198
      Location:484578
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:9192
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:210261
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:10192
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001256691.2NP_001243620.1  maternal embryonic leucine zipper kinase isoform 7

      See identical proteins and their annotated locations for NP_001243620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) initiates translation at an alternate start codon and lacks two exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AI590871, AK293423, BP365611, W01871
      UniProtKB/TrEMBL
      B7Z1G6, Q53GX0
      Conserved Domains (4) summary
      cd12198
      Location:475569
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:201252
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7183
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001256692.2NP_001243621.1  maternal embryonic leucine zipper kinase isoform 8

      See identical proteins and their annotated locations for NP_001243621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks three exons in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI590871, AK302374, DB368226
      Consensus CDS
      CCDS59128.1
      UniProtKB/TrEMBL
      B7Z450
      Related
      ENSP00000439184.1, ENST00000536987.5
      Conserved Domains (4) summary
      cd12198
      Location:424518
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:5132
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:150201
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:5132
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001256693.2NP_001243622.1  maternal embryonic leucine zipper kinase isoform 9

      See identical proteins and their annotated locations for NP_001243622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two consecutive exons in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI590871, AK301131, BP365611, W01871
      UniProtKB/TrEMBL
      B7Z450
      Conserved Domains (3) summary
      cd12198
      Location:361455
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      cd14341
      Location:87138
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:169
      PKc_like; Protein Kinases, catalytic domain
    9. NM_014791.4NP_055606.1  maternal embryonic leucine zipper kinase isoform 1

      See identical proteins and their annotated locations for NP_055606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI590871, D79997, DB368226
      Consensus CDS
      CCDS6606.1
      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
      Related
      ENSP00000298048.2, ENST00000298048.7
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

    RNA

    1. NR_046337.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI590871, AK296820, BC014039
      Related
      ENST00000627766.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      36572895..36677682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518076.3XP_011516378.1  maternal embryonic leucine zipper kinase isoform X1

      See identical proteins and their annotated locations for XP_011516378.1

      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    2. XM_047424171.1XP_047280127.1  maternal embryonic leucine zipper kinase isoform X4

      UniProtKB/TrEMBL
      Q53GX0
    3. XM_047424168.1XP_047280124.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q53GX0
    4. XM_047424180.1XP_047280136.1  maternal embryonic leucine zipper kinase isoform X7

      UniProtKB/TrEMBL
      Q53GX0
    5. XM_047424173.1XP_047280129.1  maternal embryonic leucine zipper kinase isoform X5

      UniProtKB/TrEMBL
      Q53GX0
    6. XM_047424192.1XP_047280148.1  maternal embryonic leucine zipper kinase isoform X12

      UniProtKB/TrEMBL
      Q53GX0
    7. XM_047424185.1XP_047280141.1  maternal embryonic leucine zipper kinase isoform X9

      UniProtKB/TrEMBL
      Q53GX0
    8. XM_011518082.3XP_011516384.1  maternal embryonic leucine zipper kinase isoform X3

      See identical proteins and their annotated locations for XP_011516384.1

      UniProtKB/TrEMBL
      Q53GX0
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    9. XM_047424182.1XP_047280138.1  maternal embryonic leucine zipper kinase isoform X8

      UniProtKB/TrEMBL
      Q53GX0
    10. XM_047424177.1XP_047280133.1  maternal embryonic leucine zipper kinase isoform X6

      UniProtKB/TrEMBL
      Q53GX0
    11. XM_047424195.1XP_047280151.1  maternal embryonic leucine zipper kinase isoform X13

      UniProtKB/TrEMBL
      Q53GX0
    12. XM_047424187.1XP_047280143.1  maternal embryonic leucine zipper kinase isoform X10

      UniProtKB/TrEMBL
      B7Z1G6, Q53GX0
    13. XM_047424204.1XP_047280160.1  maternal embryonic leucine zipper kinase isoform X17

    14. XM_047424166.1XP_047280122.1  maternal embryonic leucine zipper kinase isoform X1

      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
    15. XM_011518077.2XP_011516379.1  maternal embryonic leucine zipper kinase isoform X1

      See identical proteins and their annotated locations for XP_011516379.1

      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    16. XM_047424170.1XP_047280126.1  maternal embryonic leucine zipper kinase isoform X4

      UniProtKB/TrEMBL
      Q53GX0
    17. XM_047424169.1XP_047280125.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q53GX0
    18. XM_047424179.1XP_047280135.1  maternal embryonic leucine zipper kinase isoform X7

      UniProtKB/TrEMBL
      Q53GX0
    19. XM_047424172.1XP_047280128.1  maternal embryonic leucine zipper kinase isoform X5

      UniProtKB/TrEMBL
      Q53GX0
    20. XM_047424191.1XP_047280147.1  maternal embryonic leucine zipper kinase isoform X12

      UniProtKB/TrEMBL
      Q53GX0
    21. XM_047424186.1XP_047280142.1  maternal embryonic leucine zipper kinase isoform X9

      UniProtKB/TrEMBL
      Q53GX0
    22. XM_047424200.1XP_047280156.1  maternal embryonic leucine zipper kinase isoform X16

      UniProtKB/TrEMBL
      Q53GX0
    23. XM_011518081.3XP_011516383.1  maternal embryonic leucine zipper kinase isoform X3

      See identical proteins and their annotated locations for XP_011516383.1

      UniProtKB/TrEMBL
      Q53GX0
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    24. XM_047424183.1XP_047280139.1  maternal embryonic leucine zipper kinase isoform X8

      UniProtKB/TrEMBL
      Q53GX0
    25. XM_047424176.1XP_047280132.1  maternal embryonic leucine zipper kinase isoform X6

      UniProtKB/TrEMBL
      Q53GX0
    26. XM_047424193.1XP_047280149.1  maternal embryonic leucine zipper kinase isoform X13

      UniProtKB/TrEMBL
      Q53GX0
    27. XM_047424188.1XP_047280144.1  maternal embryonic leucine zipper kinase isoform X10

      UniProtKB/TrEMBL
      B7Z1G6, Q53GX0
    28. XM_047424203.1XP_047280159.1  maternal embryonic leucine zipper kinase isoform X17

    29. XM_047424197.1XP_047280153.1  maternal embryonic leucine zipper kinase isoform X14

      UniProtKB/TrEMBL
      Q53GX0
    30. XM_011518080.1XP_011516382.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q53GX0
      Conserved Domains (3) summary
      cd12198
      Location:526620
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    31. XM_047424178.1XP_047280134.1  maternal embryonic leucine zipper kinase isoform X7

      UniProtKB/TrEMBL
      Q53GX0
    32. XM_047424189.1XP_047280145.1  maternal embryonic leucine zipper kinase isoform X12

      UniProtKB/TrEMBL
      Q53GX0
    33. XM_047424184.1XP_047280140.1  maternal embryonic leucine zipper kinase isoform X9

      UniProtKB/TrEMBL
      Q53GX0
    34. XM_047424199.1XP_047280155.1  maternal embryonic leucine zipper kinase isoform X16

      UniProtKB/TrEMBL
      Q53GX0
    35. XM_047424181.1XP_047280137.1  maternal embryonic leucine zipper kinase isoform X8

      UniProtKB/TrEMBL
      Q53GX0
    36. XM_047424174.1XP_047280130.1  maternal embryonic leucine zipper kinase isoform X6

      UniProtKB/TrEMBL
      Q53GX0
    37. XM_047424194.1XP_047280150.1  maternal embryonic leucine zipper kinase isoform X13

      UniProtKB/TrEMBL
      Q53GX0
    38. XM_047424202.1XP_047280158.1  maternal embryonic leucine zipper kinase isoform X17

    39. XM_047424196.1XP_047280152.1  maternal embryonic leucine zipper kinase isoform X14

      UniProtKB/TrEMBL
      Q53GX0
    40. XM_047424206.1XP_047280162.1  maternal embryonic leucine zipper kinase isoform X19

    41. XM_011518085.2XP_011516387.1  maternal embryonic leucine zipper kinase isoform X11

      UniProtKB/TrEMBL
      Q53GX0
      Conserved Domains (4) summary
      cd12198
      Location:472566
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:1180
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:198249
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    42. XM_047424205.1XP_047280161.1  maternal embryonic leucine zipper kinase isoform X18

      UniProtKB/TrEMBL
      Q53GX0
    43. XM_047424198.1XP_047280154.1  maternal embryonic leucine zipper kinase isoform X15

      UniProtKB/TrEMBL
      Q53GX0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      36595568..36700421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364299.1XP_054220274.1  maternal embryonic leucine zipper kinase isoform X1

      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
    2. XM_054364304.1XP_054220279.1  maternal embryonic leucine zipper kinase isoform X3

      UniProtKB/TrEMBL
      Q53GX0
    3. XM_054364317.1XP_054220292.1  maternal embryonic leucine zipper kinase isoform X8

      UniProtKB/TrEMBL
      Q53GX0
    4. XM_054364306.1XP_054220281.1  maternal embryonic leucine zipper kinase isoform X4

      UniProtKB/TrEMBL
      Q53GX0
    5. XM_054364314.1XP_054220289.1  maternal embryonic leucine zipper kinase isoform X7

      UniProtKB/TrEMBL
      Q53GX0
    6. XM_054364308.1XP_054220283.1  maternal embryonic leucine zipper kinase isoform X5

      UniProtKB/TrEMBL
      Q53GX0
    7. XM_054364322.1XP_054220297.1  maternal embryonic leucine zipper kinase isoform X10

      UniProtKB/TrEMBL
      B7Z1G6, Q53GX0
    8. XM_054364337.1XP_054220312.1  maternal embryonic leucine zipper kinase isoform X17

    9. XM_054364301.1XP_054220276.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q53GX0
    10. XM_054364319.1XP_054220294.1  maternal embryonic leucine zipper kinase isoform X9

      UniProtKB/TrEMBL
      Q53GX0
    11. XM_054364329.1XP_054220304.1  maternal embryonic leucine zipper kinase isoform X13

      UniProtKB/TrEMBL
      Q53GX0
    12. XM_054364326.1XP_054220301.1  maternal embryonic leucine zipper kinase isoform X12

      UniProtKB/TrEMBL
      Q53GX0
    13. XM_054364311.1XP_054220286.1  maternal embryonic leucine zipper kinase isoform X6

      UniProtKB/TrEMBL
      Q53GX0
    14. XM_054364297.1XP_054220272.1  maternal embryonic leucine zipper kinase isoform X1

      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
    15. XM_054364298.1XP_054220273.1  maternal embryonic leucine zipper kinase isoform X1

      UniProtKB/Swiss-Prot
      A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
      UniProtKB/TrEMBL
      Q53GX0
    16. XM_054364305.1XP_054220280.1  maternal embryonic leucine zipper kinase isoform X4

      UniProtKB/TrEMBL
      Q53GX0
    17. XM_054364302.1XP_054220277.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q53GX0
    18. XM_054364313.1XP_054220288.1  maternal embryonic leucine zipper kinase isoform X7

      UniProtKB/TrEMBL
      Q53GX0
    19. XM_054364307.1XP_054220282.1  maternal embryonic leucine zipper kinase isoform X5

      UniProtKB/TrEMBL
      Q53GX0
    20. XM_054364325.1XP_054220300.1  maternal embryonic leucine zipper kinase isoform X12

      UniProtKB/TrEMBL
      Q53GX0
    21. XM_054364320.1XP_054220295.1  maternal embryonic leucine zipper kinase isoform X9

      UniProtKB/TrEMBL
      Q53GX0
    22. XM_054364334.1XP_054220309.1  maternal embryonic leucine zipper kinase isoform X16

      UniProtKB/TrEMBL
      Q53GX0
    23. XM_054364303.1XP_054220278.1  maternal embryonic leucine zipper kinase isoform X3

      UniProtKB/TrEMBL
      Q53GX0
    24. XM_054364316.1XP_054220291.1  maternal embryonic leucine zipper kinase isoform X8

      UniProtKB/TrEMBL
      Q53GX0
    25. XM_054364310.1XP_054220285.1  maternal embryonic leucine zipper kinase isoform X6

      UniProtKB/TrEMBL
      Q53GX0
    26. XM_054364327.1XP_054220302.1  maternal embryonic leucine zipper kinase isoform X13

      UniProtKB/TrEMBL
      Q53GX0
    27. XM_054364321.1XP_054220296.1  maternal embryonic leucine zipper kinase isoform X10

      UniProtKB/TrEMBL
      B7Z1G6, Q53GX0
    28. XM_054364336.1XP_054220311.1  maternal embryonic leucine zipper kinase isoform X17

    29. XM_054364331.1XP_054220306.1  maternal embryonic leucine zipper kinase isoform X14

      UniProtKB/TrEMBL
      Q53GX0
    30. XM_054364300.1XP_054220275.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q53GX0
    31. XM_054364312.1XP_054220287.1  maternal embryonic leucine zipper kinase isoform X7

      UniProtKB/TrEMBL
      Q53GX0
    32. XM_054364324.1XP_054220299.1  maternal embryonic leucine zipper kinase isoform X12

      UniProtKB/TrEMBL
      Q53GX0
    33. XM_054364318.1XP_054220293.1  maternal embryonic leucine zipper kinase isoform X9

      UniProtKB/TrEMBL
      Q53GX0
    34. XM_054364333.1XP_054220308.1  maternal embryonic leucine zipper kinase isoform X16

      UniProtKB/TrEMBL
      Q53GX0
    35. XM_054364315.1XP_054220290.1  maternal embryonic leucine zipper kinase isoform X8

      UniProtKB/TrEMBL
      Q53GX0
    36. XM_054364309.1XP_054220284.1  maternal embryonic leucine zipper kinase isoform X6

      UniProtKB/TrEMBL
      Q53GX0
    37. XM_054364328.1XP_054220303.1  maternal embryonic leucine zipper kinase isoform X13

      UniProtKB/TrEMBL
      Q53GX0
    38. XM_054364335.1XP_054220310.1  maternal embryonic leucine zipper kinase isoform X17

    39. XM_054364330.1XP_054220305.1  maternal embryonic leucine zipper kinase isoform X14

      UniProtKB/TrEMBL
      Q53GX0
    40. XM_054364339.1XP_054220314.1  maternal embryonic leucine zipper kinase isoform X19

    41. XM_054364323.1XP_054220298.1  maternal embryonic leucine zipper kinase isoform X11

      UniProtKB/TrEMBL
      Q53GX0
    42. XM_054364338.1XP_054220313.1  maternal embryonic leucine zipper kinase isoform X18

      UniProtKB/TrEMBL
      Q53GX0
    43. XM_054364332.1XP_054220307.1  maternal embryonic leucine zipper kinase isoform X15

      UniProtKB/TrEMBL
      Q53GX0