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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_041793.1 RefSeqGene
- Range
-
5001..66159
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1241
mRNA and Protein(s)
-
NM_001190720.3 → NP_001177649.2 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in an upstream AUG start codon, as compared to variant 1. The resulting isoform (2) is slightly shorter and has a different N-terminus, as compared to isoform 1.
- Source sequence(s)
-
AC083973, AK091297, AK302723
- Consensus CDS
-
CCDS55228.2
- UniProtKB/TrEMBL
- A0A499FJS7, B4DP95
- Related
- ENSP00000430868.2, ENST00000520835.7
- Conserved Domains (4) summary
-
- cd17046
Location:246 → 326
- Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
- pfam12179
Location:642 → 678
- IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
- pfam18397
Location:325 → 599
- IKBKB_SDD; IQBAL scaffold dimerization domain
- cl21453
Location:1 → 245
- PKc_like; Protein Kinases, catalytic domain
-
NM_001242778.2 → NP_001229707.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 5
See identical proteins and their annotated locations for NP_001229707.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region and uses an alternate start codon, compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus, compared to variant 1.
- Source sequence(s)
-
AC083973, AI379342, AK303528, DA159382
- UniProtKB/TrEMBL
-
B4DP95
- Conserved Domains (3) summary
-
- smart00220
Location:8 → 231
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- pfam12179
Location:649 → 683
- IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
- cl21453
Location:8 → 250
- PKc_like; Protein Kinases, catalytic domain
-
NM_001556.3 → NP_001547.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1
See identical proteins and their annotated locations for NP_001547.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AF080158, AI379342, BC090865, DA709000
- Consensus CDS
-
CCDS6128.1
- UniProtKB/Swiss-Prot
- B4DZ30, B4E0U4, O14920, O75327
- UniProtKB/TrEMBL
-
B4DP95
- Related
- ENSP00000430684.1, ENST00000520810.6
- Conserved Domains (4) summary
-
- cd14038
Location:20 → 309
- STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
- cd17046
Location:310 → 390
- Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
- pfam12179
Location:708 → 742
- IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
- pfam18397
Location:389 → 663
- IKBKB_SDD; IQBAL scaffold dimerization domain
RNA
-
NR_033818.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) has an additional segment in the CDS, resulting in reading frame-shift and earlier translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.
- Source sequence(s)
-
AC083973, AI379342, BC090865, DA159382
- Related
-
ENST00000342222.6
-
NR_033819.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks an exon in the 3' CDS, resulting in reading frame-shift and earlier translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.
- Source sequence(s)
-
AC083973, AI379342, AK290952, BC108694, DA105584
- Related
-
ENST00000416505.7
-
NR_040009.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC083973, AI379342, BC144080, DA159382
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000008.11 Reference GRCh38.p14 Primary Assembly
- Range
-
42271302..42332460
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047421762.1 → XP_047277718.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8
- UniProtKB/TrEMBL
-
B4DP95
-
XM_011544520.3 → XP_011542822.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5
- UniProtKB/TrEMBL
-
B4DP95
- Conserved Domains (4) summary
-
- smart00220
Location:38 → 205
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- pfam12179
Location:623 → 650
- IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
- pfam13900
Location:700 → 720
- GVQW; Putative domain of unknown function
- cl21453
Location:45 → 224
- PKc_like; Protein Kinases, catalytic domain
-
XM_011544517.3 → XP_011542819.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
See identical proteins and their annotated locations for XP_011542819.1
- Conserved Domains (3) summary
-
- smart00220
Location:15 → 290
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14038
Location:20 → 309
- STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
- pfam13900
Location:785 → 805
- GVQW; Putative domain of unknown function
-
XM_047421758.1 → XP_047277714.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3
-
XM_047421764.1 → XP_047277720.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X10
- UniProtKB/TrEMBL
- A8K4I7, G3V105
- Related
- ENSP00000428186.1, ENST00000521661.5
-
XM_047421757.1 → XP_047277713.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2
- UniProtKB/Swiss-Prot
- B4DZ30, B4E0U4, O14920, O75327
- UniProtKB/TrEMBL
-
B4DP95
-
XM_047421760.1 → XP_047277716.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X6
- UniProtKB/TrEMBL
-
B4DP95
-
XM_047421761.1 → XP_047277717.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X7
- UniProtKB/TrEMBL
-
B4DP95
-
XM_047421759.1 → XP_047277715.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4
- UniProtKB/TrEMBL
-
B4DP95
-
XM_047421763.1 → XP_047277719.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X9
- UniProtKB/TrEMBL
-
B3KRB7
Alternate T2T-CHM13v2.0
Genomic
-
NC_060932.1 Alternate T2T-CHM13v2.0
- Range
-
42545654..42606501
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054360434.1 → XP_054216409.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8
- UniProtKB/TrEMBL
-
B4DP95
-
XM_054360431.1 → XP_054216406.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5
- UniProtKB/TrEMBL
-
B4DP95
-
XM_054360429.1 → XP_054216404.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3
-
XM_054360427.1 → XP_054216402.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
-
XM_054360436.1 → XP_054216411.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X10
- UniProtKB/TrEMBL
- A8K4I7, G3V105
-
XM_054360428.1 → XP_054216403.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2
- UniProtKB/Swiss-Prot
- B4DZ30, B4E0U4, O14920, O75327
- UniProtKB/TrEMBL
-
B4DP95
-
XM_054360432.1 → XP_054216407.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X6
- UniProtKB/TrEMBL
-
B4DP95
-
XM_054360433.1 → XP_054216408.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X7
- UniProtKB/TrEMBL
-
B4DP95
-
XM_054360430.1 → XP_054216405.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4
- UniProtKB/TrEMBL
-
B4DP95
-
XM_054360435.1 → XP_054216410.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X9
- UniProtKB/TrEMBL
-
B3KRB7
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001190721.1: Suppressed sequence
- Description
- NM_001190721.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
-
NM_001190722.1: Suppressed sequence
- Description
- NM_001190722.1: This RefSeq was permanently suppressed because there is not sufficient data to support this transcript.