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    NFYC nuclear transcription factor Y subunit gamma [ Homo sapiens (human) ]

    Gene ID: 4802, updated on 9-Dec-2024

    Summary

    Official Symbol
    NFYCprovided by HGNC
    Official Full Name
    nuclear transcription factor Y subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:7806
    See related
    Ensembl:ENSG00000066136 MIM:605344; AllianceGenome:HGNC:7806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A
    Summary
    This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.6), heart (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NFYC in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40691704..40771603)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40560898..40640813)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41157376..41237275)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 730 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:41093974-41095173 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene uncharacterized LOC105378675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41128965-41129622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 852 Neighboring gene NFYC antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 733 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:41174578-41175204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41180095-41180734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 854 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41253587-41254086 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:41267963-41268147 Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41279047-41279546 Neighboring gene RNA, 7SL, cytoplasmic 326, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41286429-41286930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41290219-41291122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41300271-41300796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41305349-41305957 Neighboring gene uncharacterized LOC105378676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 856

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ45775, DKFZp667G242

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CCAAT-binding factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CCAAT-binding factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear transcription factor Y subunit gamma
    Names
    CAAT box DNA-binding protein subunit C
    CCAAT binding factor subunit C
    CCAAT transcription binding factor subunit gamma
    histone H1 transcription factor large subunit 2A
    nuclear transcription factor Y subunit C
    nuclear transcription factor Y, gamma
    transactivator HSM-1
    transactivator HSM-1/2
    transcription factor NF-Y, C subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142587.2NP_001136059.1  nuclear transcription factor Y subunit gamma isoform 3

      See identical proteins and their annotated locations for NP_001136059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) has the same N- and C- termini but lacks an internal segment and one residue near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AB208975, AL354914, D89986, DC391720
      Consensus CDS
      CCDS44121.1
      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000408867.2, ENST00000456393.6
      Conserved Domains (1) summary
      COG5208
      Location:17123
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    2. NM_001142588.2NP_001136060.1  nuclear transcription factor Y subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_001136060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC119677, AK300774, AL354914, D89986, DC391720
      Consensus CDS
      CCDS44120.1
      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000396620.2, ENST00000425457.6
      Conserved Domains (1) summary
      cl28542
      Location:17123
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    3. NM_001142589.2NP_001136061.1  nuclear transcription factor Y subunit gamma isoform 4

      See identical proteins and their annotated locations for NP_001136061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has the same N- and C- termini but lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AB208975, AK301385, D89986
      Consensus CDS
      CCDS44123.1
      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000408315.2, ENST00000427410.6
      Conserved Domains (1) summary
      COG5208
      Location:1785
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    4. NM_001142590.2NP_001136062.1  nuclear transcription factor Y subunit gamma isoform 5

      See identical proteins and their annotated locations for NP_001136062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate splice pattern in the 5' UTR, lacks an alternate exon in the 3' coding region, and uses an alternate splice site in the central coding region, compared to variant 1. the resulting isoform (5) has the same N- and C- termini but lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AC119677, AK127677, AL031289, AL354914, D89986, DC297902
      Consensus CDS
      CCDS44122.1
      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000361737.1, ENST00000372653.5
      Conserved Domains (1) summary
      COG5208
      Location:17123
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    5. NM_001308114.1NP_001295043.1  nuclear transcription factor Y subunit gamma isoform 6

      See identical proteins and their annotated locations for NP_001295043.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice acceptor site in the 3' terminal exon compared to variant 1. The resulting isoform (6) has the same N- and C- termini but contains an additional segment in the 3' coding region, compared to isoform 1.
      Source sequence(s)
      AF191744, AK000346, BP230898, BU634106
      Consensus CDS
      CCDS81305.1
      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
      Related
      ENSP00000312617.5, ENST00000308733.9
      Conserved Domains (1) summary
      cl28542
      Location:17123
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    6. NM_001308115.2NP_001295044.1  nuclear transcription factor Y subunit gamma isoform 7

      See identical proteins and their annotated locations for NP_001295044.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks an alternate in-frame exon in the central coding region, and uses an alternate in-frame splice acceptor site in the 3' terminal exon compared to variant 1. The resulting isoform (7) has the same N- and C- termini but lacks a segment in the central coding region, and contains an additional segment in the 3' coding region, compared to isoform 1.
      Source sequence(s)
      AK000346, BP230898, BU634106
      Consensus CDS
      CCDS81306.1
      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000361736.1, ENST00000372652.5
      Conserved Domains (1) summary
      pfam00808
      Location:42105
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    7. NM_014223.5NP_055038.2  nuclear transcription factor Y subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_055038.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C- termini but lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC119677, BC005003, D89986, DC391720
      Consensus CDS
      CCDS455.1
      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000404427.3, ENST00000447388.8
      Conserved Domains (1) summary
      COG5208
      Location:17123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40691704..40771603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001365.3XP_016856854.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
      Conserved Domains (1) summary
      cl28542
      Location:17123
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    2. XM_006710661.3XP_006710724.1  nuclear transcription factor Y subunit gamma isoform X2

      See identical proteins and their annotated locations for XP_006710724.1

      UniProtKB/Swiss-Prot
      Q13952
      Conserved Domains (1) summary
      pfam00808
      Location:42105
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    3. XM_047421386.1XP_047277342.1  nuclear transcription factor Y subunit gamma isoform X17

    4. XM_047421368.1XP_047277324.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    5. XM_047421353.1XP_047277309.1  nuclear transcription factor Y subunit gamma isoform X6

    6. XM_047421376.1XP_047277332.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    7. XM_047421347.1XP_047277303.1  nuclear transcription factor Y subunit gamma isoform X3

    8. XM_047421359.1XP_047277315.1  nuclear transcription factor Y subunit gamma isoform X10

    9. XM_047421357.1XP_047277313.1  nuclear transcription factor Y subunit gamma isoform X8

    10. XM_047421358.1XP_047277314.1  nuclear transcription factor Y subunit gamma isoform X9

    11. XM_047421389.1XP_047277345.1  nuclear transcription factor Y subunit gamma isoform X19

    12. XM_047421390.1XP_047277346.1  nuclear transcription factor Y subunit gamma isoform X20

    13. XM_047421351.1XP_047277307.1  nuclear transcription factor Y subunit gamma isoform X2

    14. XM_047421348.1XP_047277304.1  nuclear transcription factor Y subunit gamma isoform X4

    15. XM_006710660.4XP_006710723.2  nuclear transcription factor Y subunit gamma isoform X14

      See identical proteins and their annotated locations for XP_006710723.2

      UniProtKB/Swiss-Prot
      Q13952
      Conserved Domains (1) summary
      cl28542
      Location:17123
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    16. XM_047421337.1XP_047277293.1  nuclear transcription factor Y subunit gamma isoform X2

    17. XM_047421384.1XP_047277340.1  nuclear transcription factor Y subunit gamma isoform X15

      Related
      ENSP00000414299.2, ENST00000440226.7
    18. XM_017001369.2XP_016856858.1  nuclear transcription factor Y subunit gamma isoform X15

      UniProtKB/Swiss-Prot
      Q13952
      Related
      ENSP00000361734.1, ENST00000372651.5
      Conserved Domains (1) summary
      COG5208
      Location:17123
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    19. XM_017001366.3XP_016856855.1  nuclear transcription factor Y subunit gamma isoform X22

    20. XM_047421385.1XP_047277341.1  nuclear transcription factor Y subunit gamma isoform X16

    21. XM_047421391.1XP_047277347.1  nuclear transcription factor Y subunit gamma isoform X21

    22. XM_024447356.2XP_024303124.1  nuclear transcription factor Y subunit gamma isoform X18

      Conserved Domains (1) summary
      cl28542
      Location:87193
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    23. XM_047421362.1XP_047277318.1  nuclear transcription factor Y subunit gamma isoform X11

    24. XM_047421356.1XP_047277312.1  nuclear transcription factor Y subunit gamma isoform X7

    25. XM_017001364.3XP_016856853.1  nuclear transcription factor Y subunit gamma isoform X12

    26. XM_024447357.1XP_024303125.1  nuclear transcription factor Y subunit gamma isoform X15

      Conserved Domains (1) summary
      COG5208
      Location:17123
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    27. XM_006710658.4XP_006710721.3  nuclear transcription factor Y subunit gamma isoform X5

    28. XM_047421373.1XP_047277329.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    29. XM_005270895.5XP_005270952.4  nuclear transcription factor Y subunit gamma isoform X1

      Conserved Domains (1) summary
      cl28542
      Location:103209
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      40560898..40640813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336774.1XP_054192749.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    2. XM_054336778.1XP_054192753.1  nuclear transcription factor Y subunit gamma isoform X2

    3. XM_054336782.1XP_054192757.1  nuclear transcription factor Y subunit gamma isoform X17

    4. XM_054336767.1XP_054192742.1  nuclear transcription factor Y subunit gamma isoform X6

    5. XM_054336776.1XP_054192751.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    6. XM_054336763.1XP_054192738.1  nuclear transcription factor Y subunit gamma isoform X3

    7. XM_054336771.1XP_054192746.1  nuclear transcription factor Y subunit gamma isoform X10

    8. XM_054336769.1XP_054192744.1  nuclear transcription factor Y subunit gamma isoform X8

    9. XM_054336770.1XP_054192745.1  nuclear transcription factor Y subunit gamma isoform X9

    10. XM_054336784.1XP_054192759.1  nuclear transcription factor Y subunit gamma isoform X19

    11. XM_054336785.1XP_054192760.1  nuclear transcription factor Y subunit gamma isoform X20

    12. XM_054336766.1XP_054192741.1  nuclear transcription factor Y subunit gamma isoform X2

    13. XM_054336764.1XP_054192739.1  nuclear transcription factor Y subunit gamma isoform X4

    14. XM_054336777.1XP_054192752.1  nuclear transcription factor Y subunit gamma isoform X14

    15. XM_054336762.1XP_054192737.1  nuclear transcription factor Y subunit gamma isoform X2

    16. XM_054336779.1XP_054192754.1  nuclear transcription factor Y subunit gamma isoform X15

    17. XM_054336781.1XP_054192756.1  nuclear transcription factor Y subunit gamma isoform X15

    18. XM_054336787.1XP_054192762.1  nuclear transcription factor Y subunit gamma isoform X22

    19. XM_054336780.1XP_054192755.1  nuclear transcription factor Y subunit gamma isoform X16

    20. XM_054336786.1XP_054192761.1  nuclear transcription factor Y subunit gamma isoform X21

    21. XM_054336783.1XP_054192758.1  nuclear transcription factor Y subunit gamma isoform X18

    22. XM_054336772.1XP_054192747.1  nuclear transcription factor Y subunit gamma isoform X11

    23. XM_054336768.1XP_054192743.1  nuclear transcription factor Y subunit gamma isoform X7

    24. XM_054336773.1XP_054192748.1  nuclear transcription factor Y subunit gamma isoform X12

    25. XM_054336788.1XP_054192763.1  nuclear transcription factor Y subunit gamma isoform X15

    26. XM_054336765.1XP_054192740.1  nuclear transcription factor Y subunit gamma isoform X5

    27. XM_054336775.1XP_054192750.1  nuclear transcription factor Y subunit gamma isoform X13

      UniProtKB/Swiss-Prot
      B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    28. XM_054336761.1XP_054192736.1  nuclear transcription factor Y subunit gamma isoform X1