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    ZNF525 zinc finger protein 525 [ Homo sapiens (human) ]

    Gene ID: 170958, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZNF525provided by HGNC
    Official Full Name
    zinc finger protein 525provided by HGNC
    Primary source
    HGNC:HGNC:29423
    See related
    Ensembl:ENSG00000203326 AllianceGenome:HGNC:29423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.8), prostate (RPKM 2.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF525 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53365705..53386590)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56445220..56466092)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53868958..53889843)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 6, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53836118-53836982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15065 Neighboring gene zinc finger protein 845 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene zinc finger protein 765 Neighboring gene putative zinc finger protein 137 Neighboring gene ribosomal protein L39 pseudogene 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ZNF765-ZNF761

    Readthrough gene: ZNF765-ZNF761, Included gene: ZNF765, Included gene: ZNF761

    Clone Names

    • KIAA1979

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348156.2NP_001335085.1  zinc finger protein 525 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010467, AC125388, AK097037, BQ028675, BX952742, DA790976
      Consensus CDS
      CCDS86802.1
      UniProtKB/Swiss-Prot
      J3KR51, Q8N782, Q8TF23
      Related
      ENSP00000417696.1, ENST00000474037.6
      Conserved Domains (3) summary
      COG5048
      Location:130393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273293
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:748
      KRAB; KRAB box
    2. NM_001348157.2NP_001335086.1  zinc finger protein 525 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC010467, AC125388, BQ028675, DA790976, DB221179
      Consensus CDS
      CCDS86803.1
      UniProtKB/TrEMBL
      J3KR62
      Related
      ENSP00000419136.1, ENST00000467003.1
      Conserved Domains (5) summary
      COG5048
      Location:94357
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:231282
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:237257
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:277302
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:112
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RNA

    1. NR_145445.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010467, AC125388, AK097037, BQ028675, BX952742, DA790976
    2. NR_145446.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5'exon, alternate internal exon, and uses an alternate splice site in the 3' exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC010467, AC125388, AK097037, BQ028675
    3. NR_145447.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC125388, AK097037, BQ028675, DA790976
      Related
      ENST00000475179.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53365705..53386590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56445220..56466092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)