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    AATF apoptosis antagonizing transcription factor [ Homo sapiens (human) ]

    Gene ID: 26574, updated on 3-Dec-2024

    Summary

    Official Symbol
    AATFprovided by HGNC
    Official Full Name
    apoptosis antagonizing transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:19235
    See related
    Ensembl:ENSG00000275700 MIM:608463; AllianceGenome:HGNC:19235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DED; BFR2; CHE1; CHE-1
    Summary
    The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 16.6), appendix (RPKM 15.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AATF in Genome Data Viewer
    Location:
    17q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36948954..37056871)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37936011..38043848)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35306254..35414171)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35219226-35220198 Neighboring gene Sharpr-MPRA regulatory region 13221 Neighboring gene Sharpr-MPRA regulatory region 9746 Neighboring gene LHX1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35275423-35275942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35275943-35276460 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:35278241-35279440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35289047-35289564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35289565-35290082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35290165-35291080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35292909-35293822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35294081-35294922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35295765-35296606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35298089-35298612 Neighboring gene VISTA enhancer hs363 Neighboring gene LIM homeobox 1 Neighboring gene MPRA-validated peak2828 silencer Neighboring gene uncharacterized LOC105371753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35405396-35405896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35421791-35422346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35422902-35423456 Neighboring gene microRNA 2909 Neighboring gene NANOG hESC enhancer GRCh37_chr17:35446662-35447163 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:35453499-35454698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35460987-35461591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35464014-35464618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35464619-35465223 Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene NANOG hESC enhancer GRCh37_chr17:35499293-35499794 Neighboring gene high mobility group box 1 pseudogene 24 Neighboring gene ribosomal protein S2 pseudogene 49

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables leucine zipper domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic cleavage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of amyloid precursor protein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein AATF
    Names
    rb-binding protein Che-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411094.1NP_001398023.1  protein AATF isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC243773, AC244093
      Consensus CDS
      CCDS92291.1
      UniProtKB/TrEMBL
      A0A7P0T868, A0A7P0TAR0
      Related
      ENSP00000506264.1, ENST00000680340.1
    2. NM_012138.4NP_036270.1  protein AATF isoform 1

      See identical proteins and their annotated locations for NP_036270.1

      Status: REVIEWED

      Source sequence(s)
      AF083208, AK057229, BC000591
      Consensus CDS
      CCDS32632.1
      UniProtKB/Swiss-Prot
      A6NCJ6, B3KQ26, Q9NY61, Q9P0A4, Q9UNX5
      UniProtKB/TrEMBL
      A0A7P0T868
      Related
      ENSP00000477848.1, ENST00000619387.5
      Conserved Domains (3) summary
      NF000535
      Location:84206
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      pfam08164
      Location:464548
      TRAUB; Apoptosis-antagonizing transcription factor, C-terminal
      pfam13339
      Location:222373
      AATF-Che1; Apoptosis antagonizing transcription factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      36948954..37056871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435748.1XP_047291704.1  protein AATF isoform X1

      UniProtKB/TrEMBL
      A0A7P0TBG4
      Related
      ENSP00000506655.1, ENST00000680579.1

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1185319..1293236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329280.1XP_054185255.1  protein AATF isoform X1

      UniProtKB/TrEMBL
      A0A7P0TBG4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      37936011..38043848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315718.1XP_054171693.1  protein AATF isoform X1

      UniProtKB/TrEMBL
      A0A7P0TBG4