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    MORF4L2 mortality factor 4 like 2 [ Homo sapiens (human) ]

    Gene ID: 9643, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MORF4L2provided by HGNC
    Official Full Name
    mortality factor 4 like 2provided by HGNC
    Primary source
    HGNC:HGNC:16849
    See related
    Ensembl:ENSG00000123562 MIM:300409; AllianceGenome:HGNC:16849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRGX; MORFL2
    Summary
    Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleolus; nucleoplasm; and plasma membrane. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 110.4), endometrium (RPKM 100.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MORF4L2 in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103675498..103688047, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102122473..102135021, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102930426..102942975, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1 Neighboring gene MORF4L2 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102951966-102952716 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102952717-102953467 Neighboring gene glycine receptor alpha 4 (pseudogene) Neighboring gene transmembrane protein 31 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102985791-102986664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102996691-102997226 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102997227-102997764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103009420-103009920 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103020819-103021470 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:103022123-103022774 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene proteolipid protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2. Kooblall KG, et al. Endocr Relat Cancer, 2022 Oct 1. PMID 35900839, Free PMC Article
    2. Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X. Sakai K, et al. Mol Cell Neurosci, 2002 Apr. PMID 11988016
    3. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics. Zhang R, et al. Life Sci, 2020 Dec 1. PMID 33011223
    4. Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment. Kuo WY, et al. Oncotarget, 2015 Apr 20. PMID 25796627, Free PMC Article
    5. Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Pezo RC, et al. Cancer Res, 2008 Jul 1. PMID 18593893, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2.
      Title: miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2.
    2. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics.
      Title: Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics.
    3. Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as MORF4L2 in lung cancer cells remaining after treatment, creating a more drug-resistant state.
      Title: Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment.
    4. The transcriptional status of four key genes, thymidylate synthase (TYMS), MORF-related gene X (MRGX), Bcl2-antagonist/killer (BAK), and ATPase, Cu(2+) transporting beta polypeptide (ATP7B), can accurately predict response to 5-FU.
      Title: Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors.
    5. can repress or activate the B-myb promoter depending on the cell type studied, suggesting that there may be tissue-specific functions of this protein
      Title: MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0026

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    mortality factor 4-like protein 2
    Names
    MORF-related gene X protein
    MSL3-2 protein
    protein MSL3-2
    transcription factor-like protein MRGX

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142418.2 → NP_001135890.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BC093013, DC419967
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    2. NM_001142419.2 → NP_001135891.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA268606
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000415476.2, ENST00000433176.6
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    3. NM_001142420.2 → NP_001135892.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    4. NM_001142421.2 → NP_001135893.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135893.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA268606
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000353643.1, ENST00000360458.5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    5. NM_001142422.2 → NP_001135894.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA268606
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    6. NM_001142423.2 → NP_001135895.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    7. NM_001142424.2 → NP_001135896.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    8. NM_001142425.2 → NP_001135897.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    9. NM_001142426.2 → NP_001135898.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000410532.1, ENST00000451301.5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    10. NM_001142427.2 → NP_001135899.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, BM835303
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    11. NM_001142428.2 → NP_001135900.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135900.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DA068448
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    12. NM_001142429.2 → NP_001135901.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DC301727
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    13. NM_001142430.2 → NP_001135902.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, BM471743, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    14. NM_001142431.2 → NP_001135903.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DA268606, DC366195
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    15. NM_001142432.2 → NP_001135904.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DC424668
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    16. NM_012286.3 → NP_036418.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_036418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000391969.2, ENST00000441076.7
      Conserved Domains (1) summary
      pfam05712
      Location:110 → 276
      MRG

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103675498..103688047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102122473..102135021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15014.1 GenPept UniProtKB/Swiss-Prot:Q15014

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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