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    DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 [ Homo sapiens (human) ]

    Gene ID: 8444, updated on 3-Dec-2024

    Summary

    Official Symbol
    DYRK3provided by HGNC
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:3094
    See related
    Ensembl:ENSG00000143479 MIM:603497; AllianceGenome:HGNC:3094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RED; REDK; DYRK5; hYAK3-2
    Summary
    This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 8.5), gall bladder (RPKM 5.7) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DYRK3 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206635536..206655158)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205899707..205919328)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206808881..206828503)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 5 Neighboring gene uncharacterized LOC124904494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206761431-206761931 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:206775241-206776440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1760 Neighboring gene DYRK3 antisense RNA 1 Neighboring gene uncharacterized LOC124904496 Neighboring gene Sharpr-MPRA regulatory region 10950 Neighboring gene uncharacterized LOC124904495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1764 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206860855-206861416 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206861417-206861978 Neighboring gene MAPK activated protein kinase 2 Neighboring gene ribosomal protein S14 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear speck organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organelle disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell cycle G2/M phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell cycle G2/M phase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress granule disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in stress granule disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stress granule disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 3
    Names
    dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5
    protein kinase Dyrk3
    regulatory erythroid kinase
    NP_001004023.1
    NP_003573.2
    XP_005273372.1
    XP_011508363.1
    XP_047288070.1
    XP_047288071.1
    XP_047288074.1
    XP_054195170.1
    XP_054195171.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004023.3NP_001004023.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

      See identical proteins and their annotated locations for NP_001004023.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. The resulting isoform (b), also known as the isoform RED-S, contains a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL591846, AU126055, BC015501, Y12735
      Consensus CDS
      CCDS31000.1
      UniProtKB/TrEMBL
      A8K574
      Related
      ENSP00000356075.3, ENST00000367108.7
      Conserved Domains (2) summary
      smart00220
      Location:189502
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:123502
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
    2. NM_003582.4NP_003573.2  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

      See identical proteins and their annotated locations for NP_003573.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a), also known as the RED-L isoform.
      Source sequence(s)
      AL591846, AU126055, BC015501, Y12735
      Consensus CDS
      CCDS30999.1
      UniProtKB/Swiss-Prot
      D3DT79, O43781, Q7Z752, Q9HBY6, Q9HBY7
      UniProtKB/TrEMBL
      A8K574
      Related
      ENSP00000356076.2, ENST00000367109.8
      Conserved Domains (2) summary
      smart00220
      Location:209522
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:143522
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206635536..206655158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432118.1XP_047288074.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

      UniProtKB/TrEMBL
      B2R859
    2. XM_005273315.5XP_005273372.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_005273372.1

      UniProtKB/TrEMBL
      A8K574
      Conserved Domains (2) summary
      smart00220
      Location:189502
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:123502
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
    3. XM_047432114.1XP_047288070.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

      UniProtKB/TrEMBL
      A8K574
    4. XM_047432115.1XP_047288071.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

      UniProtKB/TrEMBL
      A8K574
      Related
      ENSP00000356073.1, ENST00000367106.1
    5. XM_011510061.3XP_011508363.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

      UniProtKB/TrEMBL
      B2R859
      Conserved Domains (2) summary
      smart00220
      Location:174487
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:108487
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      205899707..205919328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339195.1XP_054195170.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

      UniProtKB/TrEMBL
      A8K574
    2. XM_054339196.1XP_054195171.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

      UniProtKB/TrEMBL
      B2R859