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    TMEM161B transmembrane protein 161B [ Homo sapiens (human) ]

    Gene ID: 153396, updated on 3-Dec-2024

    Summary

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    Official Symbol
    TMEM161Bprovided by HGNC
    Official Full Name
    transmembrane protein 161Bprovided by HGNC
    Primary source
    HGNC:HGNC:28483
    See related
    Ensembl:ENSG00000164180 AllianceGenome:HGNC:28483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLB3342; PRO1313
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of cardiac muscle cell action potential and regulation of heart rate. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.9), thyroid (RPKM 2.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM161B in Genome Data Viewer
    Location:
    5q14.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (88185570..88268845, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (88666901..88750114, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (87484133..87564662, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901023 Neighboring gene VISTA enhancer hs266 Neighboring gene VISTA enhancer hs267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:87253511-87254010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:87310460-87310960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:87310961-87311461 Neighboring gene NANOG hESC enhancer GRCh37_chr5:87345495-87346036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:87347843-87348384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:87348385-87348925 Neighboring gene uncharacterized LOC105379070 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:87436892-87437393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:87441563-87442343 Neighboring gene MPRA-validated peak5334 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:87484918-87486117 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:87552812-87553465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:87564449-87564948 Neighboring gene TMEM161B divergent transcript Neighboring gene RNA, 5S ribosomal pseudogene 187 Neighboring gene RPS3A pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The interaction between TMEM161B (rs768705) and paranoid personality traits in relation to the risk of major depressive disorder: Results form a longitudinal study of 7642 Chinese freshmen. Luo L, et al. J Affect Disord, 2024 Nov 15. PMID 39147160
    2. Role of rs454214 in Personality mediated Depression and Subjective Well-being. Hou B, et al. Sci Rep, 2020 Mar 30. PMID 32231262, Free PMC Article
    3. The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence. Muench C, et al. Transl Psychiatry, 2018 Jul 13. PMID 30006604, Free PMC Article
    4. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Hyde CL, et al. Nat Genet, 2016 Sep. PMID 27479909, Free PMC Article
    5. TMEM161B modulates radial glial scaffolding in neocortical development. Wang L, et al. Proc Natl Acad Sci U S A, 2023 Jan 24. PMID 36669109, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction between TMEM161B (rs768705) and paranoid personality traits in relation to the risk of major depressive disorder: Results form a longitudinal study of 7642 Chinese freshmen.
      Title: The interaction between TMEM161B (rs768705) and paranoid personality traits in relation to the risk of major depressive disorder: Results form a longitudinal study of 7642 Chinese freshmen.
    2. TMEM161B modulates radial glial scaffolding in neocortical development.
      Title: TMEM161B modulates radial glial scaffolding in neocortical development.
    3. Role of rs454214 in Personality mediated Depression and Subjective Well-being.
      Title: Role of rs454214 in Personality mediated Depression and Subjective Well-being.
    4. The previously identified major depressive disorder risk variant rs10514299 in TMEM161B-MEF2C predicts neuronal correlates of reward processing in an alcohol dependence phenotype, possibly explaining part of the shared pathophysiology and comorbidity between the disorders.
      Title: The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.
    5. Single nucleotide polymorphism in TMEM161B gene is associated with major depressive disorder.
      Title: Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic loci for retinal arteriolar microcirculation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33214

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 161B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289007.2 → NP_001275936.1  transmembrane protein 161B isoform 1

      See identical proteins and their annotated locations for NP_001275936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC010243, AK300893, AK301091, DW423642
      Consensus CDS
      CCDS75270.1
      UniProtKB/TrEMBL
      B7Z6X1, E9PCX5
      Related
      ENSP00000426354.1, ENST00000514135.5
      Conserved Domains (2) summary
      pfam10268
      Location:2 → 425
      Tmemb_161AB; Predicted transmembrane protein 161AB
      cl21549
      Location:453 → 494
      rve; Integrase core domain

    2. NM_001289008.2 → NP_001275937.1  transmembrane protein 161B isoform 3

      See identical proteins and their annotated locations for NP_001275937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, initiates translation at a downstream start codon and contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC010243, AI570193, AK300893, BX390411, BX647345, DW423642
      Consensus CDS
      CCDS75269.1
      UniProtKB/TrEMBL
      B7Z6T3, B7Z6X1
      Related
      ENSP00000421498.1, ENST00000512429.5
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 473
      Tmemb_161AB; Predicted transmembrane protein 161AB

    3. NM_001349400.2 → NP_001336329.1  transmembrane protein 161B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
      Source sequence(s)
      AC010243, AI570193, AK300893, BC037287, BF103799, BX390411, BX647345, DC377704, DW423642
      UniProtKB/TrEMBL
      B7Z6A5
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 302
      Tmemb_161AB; Predicted transmembrane protein 161AB

    4. NM_001349402.2 → NP_001336331.1  transmembrane protein 161B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
      Source sequence(s)
      AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
      UniProtKB/TrEMBL
      B7Z6A5
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 302
      Tmemb_161AB; Predicted transmembrane protein 161AB

    5. NM_001349403.2 → NP_001336332.1  transmembrane protein 161B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
      Source sequence(s)
      AC010243, AI570193, AK300893, AK301091, BC037287, BX390411, BX647345, DW423642
      UniProtKB/TrEMBL
      B7Z6A5
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 302
      Tmemb_161AB; Predicted transmembrane protein 161AB

    6. NM_001349405.2 → NP_001336334.1  transmembrane protein 161B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
      Source sequence(s)
      AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
      UniProtKB/TrEMBL
      B7Z6A5
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 302
      Tmemb_161AB; Predicted transmembrane protein 161AB

    7. NM_001349407.2 → NP_001336336.1  transmembrane protein 161B isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has a novel 3' exon structure, resulting in a novel 3' coding region and a distinct 3' UTR compared to variant 1. It encodes isoform 5 which has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC010243, AK300893, AK301091, DW423642
      UniProtKB/TrEMBL
      B7Z6X1
      Conserved Domains (1) summary
      pfam10268
      Location:2 → 438
      Tmemb_161AB; Predicted transmembrane protein 161AB

    8. NM_153354.5 → NP_699185.1  transmembrane protein 161B isoform 2

      See identical proteins and their annotated locations for NP_699185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
      Consensus CDS
      CCDS4065.1
      UniProtKB/Swiss-Prot
      Q5CZH7, Q6UWQ6, Q8NDZ6
      UniProtKB/TrEMBL
      B7Z6X1
      Related
      ENSP00000296595.6, ENST00000296595.11
      Conserved Domains (1) summary
      pfam10268
      Location:2 → 484
      Tmemb_161AB; Predicted transmembrane protein 161AB

    RNA

    1. NR_110266.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate internal exon and a 3' terminal exon that extends past a splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
      Related
      ENST00000511087.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      88185570..88268845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454373.2 → XP_024310141.1  transmembrane protein 161B isoform X8

      UniProtKB/TrEMBL
      B7Z6X1
      Conserved Domains (1) summary
      pfam10268
      Location:29 → 465
      Tmemb_161AB; Predicted transmembrane protein 161AB

    2. XM_047416812.1 → XP_047272768.1  transmembrane protein 161B isoform X5

    3. XM_024454378.2 → XP_024310146.1  transmembrane protein 161B isoform X4

      Conserved Domains (1) summary
      pfam10268
      Location:1 → 353
      Tmemb_161AB; Predicted transmembrane protein 161AB

    4. XM_024454375.2 → XP_024310143.1  transmembrane protein 161B isoform X1

      UniProtKB/TrEMBL
      B7Z6T3, B7Z6X1
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 473
      Tmemb_161AB; Predicted transmembrane protein 161AB

    5. XM_047416811.1 → XP_047272767.1  transmembrane protein 161B isoform X5

    6. XM_047416809.1 → XP_047272765.1  transmembrane protein 161B isoform X5

    7. XM_006714553.2 → XP_006714616.1  transmembrane protein 161B isoform X3

      See identical proteins and their annotated locations for XP_006714616.1

      Conserved Domains (1) summary
      pfam10268
      Location:2 → 364
      Tmemb_161AB; Predicted transmembrane protein 161AB

    8. XM_047416808.1 → XP_047272764.1  transmembrane protein 161B isoform X1

      UniProtKB/TrEMBL
      B7Z6T3, B7Z6X1

    9. XM_024454376.2 → XP_024310144.1  transmembrane protein 161B isoform X2

      Conserved Domains (1) summary
      pfam10268
      Location:29 → 391
      Tmemb_161AB; Predicted transmembrane protein 161AB

    10. XM_047416810.1 → XP_047272766.1  transmembrane protein 161B isoform X5

    11. XM_047416815.1 → XP_047272771.1  transmembrane protein 161B isoform X7

      UniProtKB/TrEMBL
      B7Z6A5
      Related
      ENSP00000425991.1, ENST00000511218.5

    12. XM_047416813.1 → XP_047272769.1  transmembrane protein 161B isoform X5

    13. XM_047416814.1 → XP_047272770.1  transmembrane protein 161B isoform X6

      UniProtKB/TrEMBL
      B7Z6A5

    RNA

    1. XR_002959844.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      88666901..88750114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351797.1 → XP_054207772.1  transmembrane protein 161B isoform X8

      UniProtKB/TrEMBL
      B7Z6X1

    2. XM_054351790.1 → XP_054207765.1  transmembrane protein 161B isoform X4

    3. XM_054351786.1 → XP_054207761.1  transmembrane protein 161B isoform X1

      UniProtKB/TrEMBL
      B7Z6T3, B7Z6X1

    4. XM_054351794.1 → XP_054207769.1  transmembrane protein 161B isoform X5

    5. XM_054351793.1 → XP_054207768.1  transmembrane protein 161B isoform X5

    6. XM_054351791.1 → XP_054207766.1  transmembrane protein 161B isoform X5

    7. XM_054351789.1 → XP_054207764.1  transmembrane protein 161B isoform X3

    8. XM_054351787.1 → XP_054207762.1  transmembrane protein 161B isoform X1

      UniProtKB/TrEMBL
      B7Z6T3, B7Z6X1

    9. XM_054351788.1 → XP_054207763.1  transmembrane protein 161B isoform X2

    10. XM_054351792.1 → XP_054207767.1  transmembrane protein 161B isoform X5

    11. XM_054351796.1 → XP_054207771.1  transmembrane protein 161B isoform X7

      UniProtKB/TrEMBL
      B7Z6A5

    12. XM_054351795.1 → XP_054207770.1  transmembrane protein 161B isoform X5

    RNA

    1. XR_008487085.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NDZ6.1 GenPept UniProtKB/Swiss-Prot:Q8NDZ6

    Gene LinkOut

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