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    TRIM11 tripartite motif containing 11 [ Homo sapiens (human) ]

    Gene ID: 81559, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRIM11provided by HGNC
    Official Full Name
    tripartite motif containing 11provided by HGNC
    Primary source
    HGNC:HGNC:16281
    See related
    Ensembl:ENSG00000154370 MIM:607868; AllianceGenome:HGNC:16281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIA1; RNF92
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TRIM11 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228393676..228406835, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227582208..227595361, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228581377..228594536, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene uncharacterized LOC124904535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228503020-228503894 Neighboring gene Sharpr-MPRA regulatory region 4086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228538867-228539366 Neighboring gene uncharacterized LOC101927401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228555546-228556114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228556115-228556682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557329-228557895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557896-228558461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228578692-228579248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228579249-228579804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228587477-228588152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228589505-228590179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228595439-228596098 Neighboring gene uncharacterized LOC124904537 Neighboring gene microRNA 6742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1920 Neighboring gene tripartite motif containing 17 Neighboring gene H3.4 histone, cluster member

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM11 and downregulation of TRIM11 enhances virus release, suggesting the interaction between HIV-1 Gag and TRIM11 PubMed
    Vpr vpr HIV-1 Vpr may indirectly regulate TRIM11 in a dose-dependent manner, which is independent of the ubiquitin system or VprBP-mediated pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of AIM2 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in suppression of viral release by host IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in suppression of viral release by host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in suppression of viral release by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM11
    Names
    RING finger protein 92
    RING-type E3 ubiquitin transferase TRIM11
    tripartite motif-containing protein 11
    NP_660215.1
    XP_011542587.1
    XP_016857901.1
    XP_054194871.1
    XP_054194872.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145214.3NP_660215.1  E3 ubiquitin-protein ligase TRIM11

      See identical proteins and their annotated locations for NP_660215.1

      Status: REVIEWED

      Source sequence(s)
      AL670729
      Consensus CDS
      CCDS31048.1
      UniProtKB/Swiss-Prot
      A6NKE2, B2RB82, B3KUS3, B4DX88, Q5VSU1, Q8NCA6, Q96F44, Q9C022
      Related
      ENSP00000284551.6, ENST00000284551.11
      Conserved Domains (3) summary
      cd15811
      Location:288456
      SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
      pfam00643
      Location:87128
      zf-B_box; B-box zinc finger
      cd16594
      Location:1357
      RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      228393676..228406835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544285.4XP_011542587.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

      Conserved Domains (3) summary
      pfam00643
      Location:87128
      zf-B_box; B-box zinc finger
      pfam15227
      Location:1656
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15811
      Location:211379
      SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
    2. XM_017002412.3XP_016857901.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

      UniProtKB/Swiss-Prot
      Q96F44
      Conserved Domains (3) summary
      pfam00643
      Location:87128
      zf-B_box; B-box zinc finger
      pfam15227
      Location:1656
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15811
      Location:287455
      SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227582208..227595361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338897.1XP_054194872.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

    2. XM_054338896.1XP_054194871.1  E3 ubiquitin-protein ligase TRIM11 isoform X1