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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_031857.1 RefSeqGene
- Range
-
5252..281075
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_002848.4 → NP_002839.1 receptor-type tyrosine-protein phosphatase O isoform b precursor
See identical proteins and their annotated locations for NP_002839.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
- Source sequence(s)
-
AC007542, DR000351, U20489
- Consensus CDS
-
CCDS8674.1
- UniProtKB/TrEMBL
-
A8K169
- Related
- ENSP00000343434.2, ENST00000348962.7
- Conserved Domains (4) summary
-
- smart00194
Location:909 → 1164
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:937 → 1165
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:434 → 526
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- pfam00041
Location:725 → 805
- fn3; Fibronectin type III domain
-
NM_030667.3 → NP_109592.1 receptor-type tyrosine-protein phosphatase O isoform a precursor
See identical proteins and their annotated locations for NP_109592.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AC007542, BC126201, DR000351
- Consensus CDS
-
CCDS8675.1
- UniProtKB/Swiss-Prot
- A0AV39, Q13101, Q16827, Q8IYG3, Q9UBF0, Q9UBT5
- UniProtKB/TrEMBL
-
A8K169
- Related
- ENSP00000281171.4, ENST00000281171.9
- Conserved Domains (3) summary
-
- cd00047
Location:965 → 1193
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:530 → 630
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- pfam00041
Location:435 → 521
- fn3; Fibronectin type III domain
-
NM_030668.3 → NP_109593.1 receptor-type tyrosine-protein phosphatase O isoform d
See identical proteins and their annotated locations for NP_109593.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. Variants 4 and 6 encode the same isoform (d), which is shorter than isoform a.
- Source sequence(s)
-
AC007542, AF187044
- Consensus CDS
-
CCDS53754.1
- UniProtKB/TrEMBL
-
A0A6I8PRG8
- Related
- ENSP00000437571.1, ENST00000542557.5
- Conserved Domains (1) summary
-
- cd14614
Location:112 → 356
- R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
-
NM_030669.3 → NP_109594.1 receptor-type tyrosine-protein phosphatase O isoform c
See identical proteins and their annotated locations for NP_109594.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 5 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
- Source sequence(s)
-
AC007542, AF187043
- Consensus CDS
-
CCDS44837.1
- UniProtKB/TrEMBL
-
A0A6I8PRG8
- Related
- ENSP00000501494.1, ENST00000674388.1
- Conserved Domains (1) summary
-
- cd00047
Location:154 → 382
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_030670.3 → NP_109595.1 receptor-type tyrosine-protein phosphatase O isoform d
See identical proteins and their annotated locations for NP_109595.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) differs in the 5' UTR and 3' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. Variants 4 and 6 encode the same isoform (d), which is shorter than isoform a.
- Source sequence(s)
-
AC007542, AF187042
- Consensus CDS
-
CCDS53754.1
- UniProtKB/TrEMBL
-
A0A6I8PRG8
- Related
- ENSP00000439234.1, ENST00000544244.5
- Conserved Domains (1) summary
-
- cd14614
Location:112 → 356
- R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
-
NM_030671.3 → NP_109596.1 receptor-type tyrosine-protein phosphatase O isoform c
See identical proteins and their annotated locations for NP_109596.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR and 3' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 5 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
- Source sequence(s)
-
AC007542, AF152378
- Consensus CDS
-
CCDS44837.1
- UniProtKB/TrEMBL
-
A0A6I8PRG8
- Related
- ENSP00000393449.2, ENST00000445537.6
- Conserved Domains (1) summary
-
- cd00047
Location:154 → 382
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...