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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029432.1 RefSeqGene
- Range
-
5046..240818
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001242508.1 → NP_001229437.1 oxysterol-binding protein-related protein 1 isoform 3
See identical proteins and their annotated locations for NP_001229437.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as OSBPL1C) lacks multiple exons from the 5' end and has an alternate 5' exon, which results in a downstream AUG start codon, compared to variant 2. The resulting isoform (3, also known as C) has a shorter N-terminus, and it lacks ankyrin repeats and the pleckstrin homology domain, but contains the sterol-binding domain, compared to isoform 2.
- Source sequence(s)
-
AF274714, AK301862
- Consensus CDS
-
CCDS56056.1
- UniProtKB/TrEMBL
-
Q6DKJ0
- Related
- ENSP00000349545.4, ENST00000357041.8
- Conserved Domains (1) summary
-
- pfam01237
Location:166 → 552
- Oxysterol_BP; Oxysterol-binding protein
-
NM_018030.4 → NP_060500.3 oxysterol-binding protein-related protein 1 isoform 1
See identical proteins and their annotated locations for NP_060500.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as ORP1S or OSBPL1A) lacks multiple exons from the 5' end and has an alternate 5' exon, which results in a downstream AUG start codon, compared to variant 2. The resulting isoform (1, also known as A) is the shortest. It lacks N-terminal ankyrin repeats and the pleckstrin homology domain, but contains the C-terminal sterol-binding domain, compared to isoform 2. Isoform 1 can bind to phospholipids but not to 25-hydroxycholesterol. It localizes to the cytosol and may function in the regulation of vesicle transport. Unlike the widespread expression of variant 2, the expression of this variant (1) appears to be limited to brain, retina, and retinal pigment epithelium/choroid tissue.
- Source sequence(s)
-
AF274714
- Consensus CDS
-
CCDS11885.1
- UniProtKB/TrEMBL
- B2RB91, Q6GSK5
- Related
- ENSP00000382372.3, ENST00000399443.7
- Conserved Domains (1) summary
-
- pfam01237
Location:35 → 421
- Oxysterol_BP; Oxysterol-binding protein
-
NM_080597.4 → NP_542164.2 oxysterol-binding protein-related protein 1 isoform 2
See identical proteins and their annotated locations for NP_542164.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as ORP1L or OSBPL1B) encodes the longest isoform (2, also known as B). Isoform 2 contains three ankyrin repeats, a pleckstrin homology domain and a sterol-binding domain. Unlike the tissue-specific expression of variant 1, this variant is widely expressed.
- Source sequence(s)
-
AF274714, AK096358, BC136452
- Consensus CDS
-
CCDS11884.1
- UniProtKB/Swiss-Prot
- B7Z7D3, Q9BXW6, Q9BZF5, Q9NW87
- UniProtKB/TrEMBL
- B0YJ56, B7ZLX8
- Related
- ENSP00000320291.3, ENST00000319481.8
- Conserved Domains (6) summary
-
- cd00204
Location:43 → 196
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- cd13285
Location:229 → 352
- PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
- pfam01237
Location:548 → 934
- Oxysterol_BP; Oxysterol-binding protein
- pfam12796
Location:10 → 111
- Ank_2; Ankyrin repeats (3 copies)
- pfam13857
Location:160 → 216
- Ank_5; Ankyrin repeats (many copies)
- sd00045
Location:43 → 78
- ANK; ANK repeat [structural motif]
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000018.10 Reference GRCh38.p14 Primary Assembly
- Range
-
24162045..24397824 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017025530.2 → XP_016881019.1 oxysterol-binding protein-related protein 1 isoform X2
- UniProtKB/TrEMBL
-
B7ZLX8
-
XM_047437287.1 → XP_047293243.1 oxysterol-binding protein-related protein 1 isoform X1
- UniProtKB/TrEMBL
-
B2RB91
Alternate T2T-CHM13v2.0
Genomic
-
NC_060942.1 Alternate T2T-CHM13v2.0
- Range
-
24356384..24592191 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054318172.1 → XP_054174147.1 oxysterol-binding protein-related protein 1 isoform X2
- UniProtKB/TrEMBL
-
B7ZLX8
-
XM_054318171.1 → XP_054174146.1 oxysterol-binding protein-related protein 1 isoform X1
- UniProtKB/TrEMBL
-
B2RB91
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_133268.1: Suppressed sequence
- Description
- NM_133268.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.