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    MPS2 Mps2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPS2
    Official Full Name
    Mps2p
    Primary source
    SGD:S000003043
    Locus tag
    YGL075C
    See related
    AllianceGenome:SGD:S000003043; FungiDB:YGL075C; VEuPathDB:YGL075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MMC1
    Summary
    Enables cytoskeleton-nuclear membrane anchor activity. Involved in several processes, including meiotic telomere tethering at nuclear periphery; protein localization to spindle pole body; and spindle pole body duplication. Located in nuclear outer membrane and spindle pole body. Part of meiotic nuclear membrane microtubule tethering complex. Is active in chromosome, telomeric region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPS2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (366925..368088, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene stress-responsive transcription factor HSF1 Neighboring gene DNA-binding transcription factor AFT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spindle pole body duplication defective yeast cells are more prone to membrane damage. Konuk HB, et al. Mycologia, 2019 Nov-Dec. PMID 31596181
    2. MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. Winey M, et al. J Cell Biol, 1991 Aug. PMID 1869587, Free PMC Article
    3. The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization. Chen J, et al. PLoS Genet, 2020 Dec. PMID 33332348, Free PMC Article
    4. Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope. Muñoz-Centeno MC, et al. Mol Biol Cell, 1999 Jul. PMID 10397772, Free PMC Article
    5. Requirement for Bbp1p in the proper mitotic functions of Cdc5p in Saccharomyces cerevisiae. Park CJ, et al. Mol Biol Cell, 2004 Apr. PMID 14767068, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
      Title: Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
    2. Mps2-Bbp1 directly interacts with Mps3 and Ndc1. We then purified Spc29 and reconstituted the ternary Mps2-Bbp1-Spc29 complex, proving that Bbp1 can simultaneously interact with Mps2 and Spc29 and in this way link the central plaque of the spindle pole body to the nuclear envelope
      Title: A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast.
    3. Mps2p-Bbp1p complex in the spindle pole body.
      Title: The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeleton-nuclear membrane anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in karyogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic telomere tethering at nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle pole body duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle pole body duplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mps2p
    NP_011440.1
    • Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      366925..368088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180940.1 → NP_011440.1  TPA: Mps2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZUA4, C7GW39, C8Z8H2, D6VU69, E7KCH6, E7KNG0, E7LUD2, E7NHN2, E7Q3U9, E7QET1, P53159
      UniProtKB/TrEMBL
      N1P5G8
      Conserved Domains (1) summary
      pfam17060
      Location:10 → 386
      MPS2; Monopolar spindle protein 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53159.1

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