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    TSACC TSSK6 activating cochaperone [ Homo sapiens (human) ]

    Gene ID: 128229, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TSACCprovided by HGNC
    Official Full Name
    TSSK6 activating cochaperoneprovided by HGNC
    Primary source
    HGNC:HGNC:30636
    See related
    Ensembl:ENSG00000163467 MIM:619679; AllianceGenome:HGNC:30636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP; SSTK-IP; C1orf182
    Summary
    Enables protein-folding chaperone binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 148.3) See more
    Orthologs
    mouse all
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    Genomic context

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    See TSACC in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156337314..156346995)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155475925..155485606)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156307105..156316786)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156271210-156271710 Neighboring gene MPRA-validated peak424 silencer Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156297025-156297871 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156297872-156298717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1859 Neighboring gene Rh family B glycoprotein Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene MIR9-1 host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene microRNA 9-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. Jha KN, et al. J Biol Chem, 2010 Nov 5. PMID 20829357, Free PMC Article
    2. Genome-wide association study of hematological and biochemical traits in a Japanese population. Kamatani Y, et al. Nat Genet, 2010 Mar. PMID 20139978
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC26877

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TSSK6-activating co-chaperone protein
    Names
    SSTK-interacting protein (SSTK-IP)
    TSSK6 activating co-chaperone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304817.2 → NP_001291746.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AK311950, BC014605, DB446801
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      D3DVB9, Q96A04
      Related
      ENSP00000357237.1, ENST00000368254.6
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    2. NM_001304818.2 → NP_001291747.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AY048672, DB446801
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      D3DVB9, Q96A04
      Related
      ENSP00000357236.1, ENST00000368253.6
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    3. NM_001304819.2 → NP_001291748.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AL589685, BC014605, HY019225, HY044099
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      D3DVB9, Q96A04
      Related
      ENSP00000357235.1, ENST00000368252.5
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    4. NM_001304820.1 → NP_001291749.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291749.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AI336861, BC014605
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      D3DVB9, Q96A04
      Related
      ENSP00000357234.1, ENST00000368251.1
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    5. NM_001304821.2 → NP_001291750.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291750.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AL589685, BC014605, HY044099, HY230397
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      D3DVB9, Q96A04
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    6. NM_001304822.2 → NP_001291751.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      BC014605, HY044771
      Consensus CDS
      CCDS76223.1
      UniProtKB/TrEMBL
      V9GYT6
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 57
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    7. NM_001304823.2 → NP_001291752.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      BC014605, HY034095
      Consensus CDS
      CCDS76223.1
      UniProtKB/TrEMBL
      V9GYT6
      Related
      ENSP00000477074.1, ENST00000470342.5
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 57
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    8. NM_001304824.2 → NP_001291753.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291753.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      AL589685, BC014605, BE464129, HY044099
      Consensus CDS
      CCDS76223.1
      UniProtKB/TrEMBL
      V9GYT6
      Related
      ENSP00000477010.1, ENST00000466306.5
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 57
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    9. NM_001304825.2 → NP_001291754.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      AL589685, BC014605, BI831108, HY044099
      Consensus CDS
      CCDS76223.1
      UniProtKB/TrEMBL
      V9GYT6
      Related
      ENSP00000476780.1, ENST00000481479.5
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 57
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    10. NM_001304826.2 → NP_001291755.1  TSSK6-activating co-chaperone protein isoform c

      See identical proteins and their annotated locations for NP_001291755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and uses two alternate splice junctions at the 5' end compared to variant 1. The resulting isoform (c) is longer at the N-terminus compared to isoform a.
      Source sequence(s)
      AL589685, AY048673, HY044099
      UniProtKB/Swiss-Prot
      Q96A04
      Conserved Domains (1) summary
      pfam15836
      Location:19 → 143
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    11. NM_144627.5 → NP_653228.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_653228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AL589685, BC014605
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      D3DVB9, Q96A04
      Related
      ENSP00000357238.3, ENST00000368255.7
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    RNA

    1. NR_130913.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs at the 5' end, lacks an alternate internal exon, and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC014605, DB446801, HY048925

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156337314..156346995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155475925..155485606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96A04.1 GenPept UniProtKB/Swiss-Prot:Q96A04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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