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    ZNF765 zinc finger protein 765 [ Homo sapiens (human) ]

    Gene ID: 91661, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZNF765provided by HGNC
    Official Full Name
    zinc finger protein 765provided by HGNC
    Primary source
    HGNC:HGNC:25092
    See related
    Ensembl:ENSG00000196417 AllianceGenome:HGNC:25092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.5), testis (RPKM 2.5) and 25 other tissues See more
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    Genomic context

    See ZNF765 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53395149..53427321)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56474647..56506876)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53898402..53930574)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 845 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene zinc finger protein 525 Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene putative zinc finger protein 137 Neighboring gene ribosomal protein L39 pseudogene 36 Neighboring gene vomeronasal 1 receptor 101 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11010 Neighboring gene tropomyosin 3 pseudogene 9 Neighboring gene zinc finger protein 761 Neighboring gene Sharpr-MPRA regulatory region 10215 Neighboring gene vomeronasal 1 receptor 102 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ZNF765-ZNF761

    Readthrough gene: ZNF765-ZNF761, Included gene: ZNF525, Included gene: ZNF761

    Clone Names

    • FLJ30902, DKFZp686J2252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040185.3NP_001035275.1  zinc finger protein 765 isoform 1

      See identical proteins and their annotated locations for NP_001035275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC022137, CD656338
      Consensus CDS
      CCDS46171.1
      UniProtKB/Swiss-Prot
      A8MYG0, B4DF18, B7ZAI5, B9EIL1, Q7L2R6, Q9BV49
      Related
      ENSP00000379689.3, ENST00000396408.8
      Conserved Domains (5) summary
      smart00349
      Location:848
      KRAB; krueppel associated box
      COG5048
      Location:325477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:329349
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:314338
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001350495.2NP_001337424.1  zinc finger protein 765 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022137
      Conserved Domains (3) summary
      COG5048
      Location:272424
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:204229
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_146721.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022137, BC017357
      Related
      ENST00000504235.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53395149..53427321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56474647..56506876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)