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    SLC35E2A solute carrier family 35 member E2A (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 9906, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC35E2Aprovided by HGNC
    Official Full Name
    solute carrier family 35 member E2A (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:20863
    See related
    AllianceGenome:HGNC:20863
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC35E2; SLC35E2P; SLC35E2AP
    Summary
    Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 10.4), ovary (RPKM 10.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SLC35E2A in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1727385..1746070, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1161752..1180438, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1658824..1677509, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 23A (pseudogene) Neighboring gene cyclin dependent kinase 11A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1655889-1656728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1660738-1661238 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1684563-1685092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1691433-1692390 Neighboring gene NAD kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1705547-1706048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 90 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 36 Neighboring gene Sharpr-MPRA regulatory region 14484 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1721473-1721656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 39 Neighboring gene G protein subunit beta 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1757447-1758350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 41 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1782535-1783035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1783210-1784022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 44 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1798007-1798184 Neighboring gene Sharpr-MPRA regulatory region 3728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1820039-1820538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 92

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. Seki N, et al. DNA Res, 1997 Oct 31. PMID 9455484
    2. The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex. Wang X, et al. Mol Brain, 2021 Mar 16. PMID 33726789, Free PMC Article
    3. Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response. Lou LQ, et al. J Mol Med (Berl), 2023 Mar. PMID 36629882
    4. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CDK11A

    Homology

    Other Names

    • solute carrier family 35 member E2

    Clone Names

    • FLJ34996, FLJ44537, MGC104754, MGC117254, MGC126715, MGC138494, DKFZp686M0869

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_173244.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL031282

    2. NR_173245.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL031282

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1727385..1746070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1161752..1180438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001199787.2: Suppressed sequence

      Description
      NM_001199787.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NM_182838.3: Suppressed sequence

      Description
      NM_182838.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CK97.1 GenPept UniProtKB/Swiss-Prot:P0CK97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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