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    NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 [ Homo sapiens (human) ]

    Gene ID: 64710, updated on 10-Dec-2024

    Summary

    Official Symbol
    NUCKS1provided by HGNC
    Official Full Name
    nuclear casein kinase and cyclin dependent kinase substrate 1provided by HGNC
    Primary source
    HGNC:HGNC:29923
    See related
    Ensembl:ENSG00000069275 MIM:611912; AllianceGenome:HGNC:29923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JC7; NUCKS
    Summary
    This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in brain (RPKM 77.7), thyroid (RPKM 69.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NUCKS1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205712822..205750182, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204977487..205014861, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205681950..205719310, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2383 Neighboring gene ETS transcription factor ELK4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205629205-205629793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631113-205631667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631668-205632223 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:205633133-205634332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2387 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205639145-205639706 Neighboring gene solute carrier family 45 member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205644516-205645016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205645017-205645517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1682 Neighboring gene uncharacterized LOC105371701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205657475-205658431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205662277-205662826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670015-205670516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670517-205671016 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205708952-205709557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205709558-205710164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205711268-205711871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205711872-205712474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2389 Neighboring gene RAB29, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205769142-205770092 Neighboring gene solute carrier family 41 member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:205779391-205779622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205782120-205782620

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (45 hits/1274 screens)

    EBI GWAS Catalog

    Description
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    EBI GWAS Catalog
    Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
    EBI GWAS Catalog
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    EBI GWAS Catalog
    Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
    EBI GWAS Catalog
    Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
    EBI GWAS Catalog
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    EBI GWAS Catalog
    Genome-wide association study reveals genetic risk underlying Parkinson's disease.
    EBI GWAS Catalog
    Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
    EBI GWAS Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat NUCKS1 enhances HIV-1 Tat-mediated transcriptional activation on the HIV-1 LTR, and knockdown of NUCKS1 by siRNA significantly reduces Tat-mediated transcriptional activation PubMed
    tat HIV-1 Tat interacts directly with both ectopically expressed and endogenous NUCKS1 in HEK293 cells PubMed
    capsid gag Overexpression of NUCKS1 moderately induces HIV-1 production with increased release of p24 without PMA stimulation in latently infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ21480, FLJ32016, FLJ38536

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular response to X-ray PubMed 
    involved_in chromatin organization  
    involved_in double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination PubMed 
    involved_in gene conversion PubMed 
    involved_in interstrand cross-link repair  
    involved_in interstrand cross-link repair PubMed 
    involved_in intracellular glucose homeostasis  
    involved_in modulation by host of RNA binding by virus PubMed 
    involved_in modulation by host of viral RNA-binding transcription factor activity PubMed 
    involved_in modulation by host of viral genome replication PubMed 
    involved_in positive regulation by host of viral genome replication PubMed 
    involved_in positive regulation by host of viral transcription PubMed 
    involved_in positive regulation of insulin receptor signaling pathway  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA replication PubMed 
    involved_in regulation of DNA strand elongation PubMed 
    involved_in regulation of insulin receptor signaling pathway  
    involved_in replication fork processing PubMed 
    Component Evidence Code Pubs
    located_in chromatin PubMed 
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
    Names
    P1
    nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
    potential LAG1 interactor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027548.1 RefSeqGene

      Range
      5063..42423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022731.5NP_073568.2  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

      See identical proteins and their annotated locations for NP_073568.2

      Status: REVIEWED

      Source sequence(s)
      AA760780, AB049824, AC119673, AK025133, AK095855, BC000805, BQ638451
      Consensus CDS
      CCDS30987.1
      UniProtKB/Swiss-Prot
      Q54AC0, Q5PXE7, Q9H1D6, Q9H1E3, Q9H723
      Related
      ENSP00000356110.4, ENST00000367142.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205712822..205750182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245453.2XP_005245510.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1

      See identical proteins and their annotated locations for XP_005245510.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      204977487..205014861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338257.1XP_054194232.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1

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